Intraarterial infusion chemotherapy IAIC Outline Introduction Anatomy Treamtnt

Intra-arterial infusion chemotherapy （IAIC） 肝動脈灌注化學療法

Outline • Introduction • Anatomy • Treamtnt • Indication • Contraindication • Materials and methods • Chemotherapy agents • Result

Anatomy

Treatment • • Operation Transcatheter arterial chemobolization(TACE) Alcohol therapy Thermal therapy Microwave coagulation therapy Radiofrequency tumor ablation Intra-arterial infusion chemotherapy(IAIC) Liver transplantion

Indication • Can not eligible for OP • Can not eligible for other local treatment • Bulky tumor mass • Multiple tumors in both lobes of the liver • tumor thrombosis of the main vessel were enrolled

Contraindication • Poor liver reserve • Poor renal function • platelet count < 60, 000/cumm • WBC<2500/cumm • BUN < 3 mg/d. L • 對顯影劑過敏者

Materials • X-ray flouroscope • Auto-injector • 超音波 • Contrast • 血管攝影包 • 板子(用來固定手部) • 導管

Chemotherapy agents • 5 -fluoroacil(5 -FU) • leucovorin • Cisplatin • Mitomycin C • Doxorubicin(小紅莓)

灌注療法 • Cisplatin (10 mg/m 2) and mitomycin-C (2 mg/m 2) were infused for 20 to 30 minutes each time and continued for 5 days. • Daily 24 hours infusion of 5 -FU (100 mg/m 2) for 5 days • leucovorin (15 mg/m 2) was given daily to improve the efficacy of 5 -FU during IAIC.

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