Intercellular Communication Overview 1 2 AUTOCRINE AKA JUXTACRINE

Intercellular Communication Overview 1

2

AUTOCRINE AKA: JUXTACRINE 3

4 ENDOCRINE

JUXTACRINE 5 NERVOUS PARACRINE, AUTOCRINE

Different Receptors Different Intracellular Events 6 Same signal Many different effects

7

8

ACTIVITY 9

Signaling Through Intracellular Receptors Hydrophobic Signaling Molecules 10

nitric oxide 11

12

Transcription Factor 13

Enzyme 14

Signaling Through Surface Receptors Hydrophilic Signaling Molecules 15

epidermal growth factor peach lactone histamine insulin acetylcholine 16

17

MESSENGERS 18

Amplify SIGNAL TRANSDUCTION 19

20

LIGAND-GATED CHANNELS 21

Enzyme & Enzyme-linked Receptors Receptor Tyrosine Kinases 22

E. g. , Epidermal Growth Factor (EGF) Insulin IGF, FGF, HGF, PDGF P (Receptor Tyrosine Kinase) 23 P Cross-Phosphorylation

24

Protein Domain Binding Partner SH 2 (Src Homology 2) Phosphotyrosine SH 3 (Src Homology 3) Poly-Proline PH (Plekstrin Homology) Phospho-Phosphotidylinositol (PI 2 P, PI 3 P) PTB (Phosphotyrosine Binding) Phosphotyrosine Structure 25

26

Ras Activation 27

EGF SH 2 SH 3 Grb 2 (an adapter protein) 28 Son of Sevenless (SOS; a GNEF for Ras)

Cell Division 29

PI Kinase Activation 30

Phosphatidylinositol Kinase 31

PH 32 PH

PH 33 PH

34

AKT 35

36

G-Protein Linked Receptors GPCRs 37

38

39

EXTRACELLULAR SPACE 40

41

42

Ion Channel Activation bg 43

44

Adenylyl Cyclase Activation a 45

adenylyl cyclase 46

47

adenylyl cyclase ATP c. AMP 48

(protein kinase A) 49

50

51

Phospholipase C Activation a 52

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54