Intellectual Property and Entrepreneurship at UAMS October 4

Intellectual Property and Entrepreneurship at UAMS October 4, 2019 Joe Underwood, JD, Ph. D Associate Director – Licensing Bio. Ventures, LLC

Roadmap Intellectual Property University Intellectual Property Bio. Ventures Background Licensing Activity Start-up Companies Entrepreneurship Programs

Intellectual Property The Congress shall have power…to promote the Progress of Science and useful Arts, by securing for limited Times to Authors and Inventors the exclusive Right to their respective Writings and Discoveries… U. S. Const. , Art. I, Sec. 8, Cl. 8

Types of Intellectual Property Patent Trademark Copyright Trade Secrets or Know How

Patents A patent is a grant of a property right from the US government to an inventor Patentee has “the right to exclude others from making, using, offering for sale, or selling the invention throughout the United States or importing the invention into the United States” The patent system encourages public disclosure of inventions thereby making it easier for improvements to be made To be patented an invention must be novel, useful and non-obvious Term of patent is 20 years from filing (plant and utility) or 14 years from date of issue (design)

Copyrights Copyright protects original works of authorship including literary, dramatic, musical, and artistic works, such as poetry, novels, movies, songs, computer software, and architecture. Copyright does not protect names, titles, coined terms, slogans or short phrases. Copyright does not protect facts, ideas, systems, or methods of operation, although it may protect the way these things are expressed. A work receives copyright protection the moment it is created and fixed in a tangible form that it is perceptible either directly or with the aid of a machine or device.

Trademarks and Service Marks A sign, design or expression to identify goods or services of a particular source Rights arise at time of actual use in commerce and continue until not used for a period of time

Trade Secrets Information that derives actual or potential economic value because it is not known or readily ascertainable by others The person/organization in possession of the secret must use reasonable efforts to keep it a secret There is no registration process for a trade secret so a secret must always be closely guarded in order to have protection

University Intellectual Property Bayh-Dole Act (1980) University of Arkansas Policy The University owns inventions made by employees using University funds or resources The University shares income from commercialization of inventions with the inventors Bio. Ventures manages the Intellectual Property on behalf of the University

Why Disclose Intellectual Property? It’s the law! The Bayh-Dole Act requires government contractors/grantees to disclose all inventions arising from research funded, in whole or in part, by the government. It’s University of Arkansas System policy! Policy 210. 1 states that the ownership of all intellectual property created by an employee of the University shall reside in the University. To benefit patients, most intellectual property will need to be commercialized

Bio. Ventures Background Founded in 1994 as the Biomedical Biotechnology Center (BBC) as part of the College of Medicine Bio. Ventures facility opened for business in 2003 BBC and its Bio. Ventures incubator program transferred to the office of VC for Research in 2007 Privatized operations into Bio. Ventures, LLC, January 1, 2017

Role of Bio. Ventures Four major functions Intellectual Property Protection and Commercialization Invention disclosures, patents, copyrights, proprietary materials Marketing and licensing to third parties Industry Outreach Developing spin-off opportunities Intellectual property, people, money Managing Bio. Ventures incubator Health sciences innovation and entrepreneurship education

Inventions Disclosures, Applications and Issued Patents 40 35 30 25 Disclosures 20 Applications Issued Patents 15 10 5 0 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019

Seven license agreements completed in FY 2019 Two to spinoff companies Licensing Activity 9 License Agreements 8 Spinoff 7 6 5 4 3 2 1 0 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019

FY 19 Intellectual Property Revenue $1. 42 million in royalty income $599 K paid out to inventors and UA System Additional $166 K received for patent cost reimbursement

Start-ups Spin off companies Resource for company formation with SBIR or STTR funding Assistance with business plan drafting Introduction to management resources to run the business Networks to assist with financing and growth of the business

UAMS Spin-off Companies Bio. Ventures Companies Agathera Therapeutics Contour. Med, Inc. e. Doc American, LLC Elder. Stay@Home, LLC Safe Foods Corporation BALM Innovations, LLC Rx. Results, LLC EZRA Innovations, LLC Amigos Solutions, LLC Phyto. TEK, LLC Children and Family Evaluation Services Angel. Eye Camera Systems, LLC Interve. Xion Therapeutics, LLC HD Nursing, LLC Stage 1 Diagnostics, Inc. Type IV Technologies, Inc. Acetaminophen Toxicity Diagnostics, LLC Tocol Pharmaceuticals, LLC Pin. Point Testing, LLC Air. TOCO, LLC Bio. Botic Solutions Spiritum Solutions Dialectic Therapeutics Product or Service Cancer vaccine therapy Custom breast forms On-line health advice Home caregiver training Food safety solutions Omnibalm skin products Pharmacy cost saving Controlled drug release Non-invasive medical devices Infection control Family-directed development training materials NICU camera systems Therapeutic antibodies Fall prevention program Reproductive cancer detection Dermatology therapeutics Detection of hepatotoxicity Radiation protection Detection of designer drugs Pneumatic tocodynamometer Pathology robotics Medical device Cancer therapy

Types of Companies Healthcare IT Lower Risk Services Diagnostics Medium Risk Devices Therapeutics High Risk

Bio. Ventures Sponsored Training Programs For Students: Health Sciences Entrepreneurship Boot Camp I-Corps STEP program (with UAF and UA Little Rock)* For Post-docs: TL 1 - Health sciences entrepreneurship certificate program for post-doctoral trainees For Faculty: fast. PACE course For everyone: Health sciences entrepreneurship seminar series Other training and mentoring Health. Tech Arkansas

Knowledge/Skills Requirements for Health Sciences Entrepreneurship Intellectual Property Regulatory/Compliance Sources of Financing Principles of Project Management

Bio. Ventures Facility Incubator Facility 401 South Cedar Street

For More Information Contact Nancy Gray or Joe Underwood (686 -6696) Website: bioventures. uams. edu