Integration architecture Queryable sources that generate XML Distributed
Integration architecture Queryable sources that generate XML Distributed queries over sources Query Manager to manage queries Saved queries as sources that can also be queried • Leads to potential for query networks • •
v. SPARQL Service RDF Store
v. SPARQL Service RDF Store
v. SPARQL Service RDF Store
QM Client QM Server QM DB v. SPARQL Service RDF Store
QM Client QM Server QM DB v. SPARQL Service RDF Store
BIRN f. MRI Study Extract centers of activation Label using Talairach XML Demon XML BIRN f. MRI Study Schizophrenics vs Healthy Controls
XML
QM Client RDF/ OWL QM Server XML QM DB v. SPARQL Service RDF Store
QM Client RDF/ OWL DXQuery Service QM Server XML QM DB v. SPARQL Service RDF Store
QM Client RDF/ OWL DXQuery Service QM Server XML QM DB v. SPARQL Service RDF Store
QM Client QE Service RDF/ OWL DXQuery Service QM Server XML QM DB v. SPARQL Service RDF Store
QM Client QE Service RDF/ OWL DXQuery Service QM Server XML QM DB v. SPARQL Service RDF Store
QM Client QE Service RDF/ OWL XML DXQuery Service QM Server XML QM DB v. SPARQL Service RDF Store
N=1741 Region Filtered Healthy (Red) Schizophrenic (Yellow) Dorso_lateral prefrontal cortex 55 25 30 Brodmann area 6 213 107 106 Frontal lobe 575 288 287
QM Client QE Service DXQuery Service QM Server QM DB v. SPARQL Service RDF Store
Other Client QM Client QE Service RDF/ OWL XML DXQuery Service QM Server v. SPARQL Service XML Other Services Remote Services QM DB RDF Store RDF/ OWL Remote Services
Other Client QM Client RDF/ OWL XML v. SPARQL Service DXQuery Service XML Other Services Remote Services Query Manager Core RDF Store RDF/ OWL Remote Services
Other Client Query Manager Core with Plugins QM Client RDF/ OWL XML v. SPARQL Service DXQuery Service XML Other Services Remote Services Query Manager Core RDF Store RDF/ OWL Remote Services
Other Client RDF/ OWL XML Query Manager XML Remote Services RDF/ OWL Remote Services
RDF/ OWL XML Query Manager XML RDF/ OWL
BIRN f. MRI and FMA Query Manager BIRN f. MRI FMA
BIRN f. MRI, VBM and FMA VBM Query Manager FMA BIRN f. MRI
Electronic Data Capture and Freezer Management EDC Query Manager Freezer Management
Biorepositories Biorepository Query Manager Biorepository
Human Studies Database Clinical Trials Metadata Query Manager Ontology of Clinical Research Clinical Trials Metadata
Ontology Views Query Manager Ontology
Summary Query Manager
Issues • • • Response time Reliability Security Discoverability Usability Integration with other systems and methods
Query Manager Future Work Query Manager
Query Manager
BIRN f. MRI Brain Imaging View FMA
Clinical View EDC
Imaging Clinical/I maging View Clinical
Gene Protein Genomic View Others….
Clinical/I maging Genomic Translational View
Query Web
Translational Medicine Query Web
A Network-centric view of information systems Semantic Web Query Web Internet
Bin Zhang
A convergence? • Biology as an information science • Information science as biology • Networks as the link
Credits • • Todd Detwiler Onard Mejino Joshua Franklin Ron Shaker • • Xenia Hertzenberg Nolan Nichols Marianne Shaw Wayne Warren • Linda Shapiro • Dan Suciu • Cornelius Rosse Funding: NLM, NIMH, NHLBI
- Slides: 59