Inhibition of EGFR HER 2 and HER 3

Inhibition of EGFR, HER 2, and HER 3 signalling in patients with colorectal cancer wildtype for BRAF, PIK 3 CA, KRAS, and NRAS (FOCUS 4 -D): a phase 2– 3 randomised trial Prof Richard Adams, MD, Ewan Brown, MD, Louise Brown, Ph. D, Rachel Butler, Ph. D, Stephen Falk, FRCR, David Fisher, MSc, Prof Richard Kaplan, Ph. D, Prof Phil Quirke, Ph. D, Susan Richman, Ph. D, Leslie Samuel, FRCR, Jenny Seligmann, Ph. D, Prof Matt Seymour, Ph. D, Kai Keen Shiu, Ph. D, Harpreet Wasan, Ph. D, Prof Richard Wilson, Ph. D, Prof Tim Maughan, Ph. D The Lancet Gastroenterology & Hepatology Volume 3 Issue 3 Pages 162 -171 (March 2018) DOI: 10. 1016/S 2468 -1253(17)30394 -1 Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4. 0 license Terms and Conditions

Figure 1 The Lancet Gastroenterology & Hepatology 2018 3162 -171 DOI: (10. 1016/S 2468 -1253(17)30394 -1) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4. 0 license Terms and Conditions

Figure 2 The Lancet Gastroenterology & Hepatology 2018 3162 -171 DOI: (10. 1016/S 2468 -1253(17)30394 -1) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4. 0 license Terms and Conditions

Figure 3 The Lancet Gastroenterology & Hepatology 2018 3162 -171 DOI: (10. 1016/S 2468 -1253(17)30394 -1) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4. 0 license Terms and Conditions

Figure 4 The Lancet Gastroenterology & Hepatology 2018 3162 -171 DOI: (10. 1016/S 2468 -1253(17)30394 -1) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4. 0 license Terms and Conditions