Inflammatory cytokines and signaling pathways are associated with
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Inflammatory cytokines and signaling pathways are associated with survival of primary chronic lymphocytic leukemia cells in vitro: a dominant role of CCL 2 by Angela Schulz, Grischa Toedt, Thorsten Zenz, Stephan Stilgenbauer, Peter Lichter, and Martina Seiffert haematol Volume 96(3): 408 -416 February 28, 2011 © 2011 by Ferrata Storti Foundation
(A) Survival rates of CLL cells in vitro under supportive culture conditions. Angela Schulz et al. Haematologica 2011; 96: 408 -416 © 2011 by Ferrata Storti Foundation
Verification of microarray data by q. RT-PCR analyses were performed with RNA isolated from CLL cells at day 0 and after 3 days of co-culture with HS-5 cells for a set of selected genes. Angela Schulz et al. Haematologica 2011; 96: 408 -416 © 2011 by Ferrata Storti Foundation
Heat map of the top 20 up- and down-regulated genes that are common to all three survivalinducing culture conditions. Angela Schulz et al. Haematologica 2011; 96: 408 -416 © 2011 by Ferrata Storti Foundation
Top canonical pathways identified by Ingenuity Pathways Analysis of differentially expressed genes common to all three survival-inducing culture conditions. Angela Schulz et al. Haematologica 2011; 96: 408 -416 © 2011 by Ferrata Storti Foundation
Top 15 cytokines present in CLL/HS-5 co-cultures showing their relative expression level compared to positive controls and their fold expression compared to pure HS-5 cultures. Angela Schulz et al. Haematologica 2011; 96: 408 -416 © 2011 by Ferrata Storti Foundation
In vitro and in vivo analysis of CCL 2 expression. Angela Schulz et al. Haematologica 2011; 96: 408 -416 © 2011 by Ferrata Storti Foundation
