Increased Serum Matrix Metalloproteinase9 Levels are Associated with

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Increased Serum Matrix Metalloproteinase-9 Levels are Associated with Anti-Jo 1 but not Anti-MDA 5

Increased Serum Matrix Metalloproteinase-9 Levels are Associated with Anti-Jo 1 but not Anti-MDA 5 in Myositis Patients Yanjuan Liu, Hui Luo, Li Wang, Caiyan Li, Liyun Liu, Li Huang, Ke Liu, Meidong Liu, Siming Gao, Yizhi Xiao, Honglin Zhu, Xiaoxia Zuo, Quan-Zhen Li, Huali Zhang 1 Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, Hunan, China 2 Department of Pathophysiology, Xiangya School of Medicine, Central South University, Hunan, China 3 Department of Immunology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. 4 Sepsis Translational Medicine Key Lab of Hunan Province, Central South University, Hunan, China Figure 3. MMP 9 concentrations were determined in culture medium of neutrophils or PBMCs stimulated with purified Ig. G from healthy control, Jo 1 -positive sera, MDA 5 -positive sera, or without Ig. G. (A) MMP 9 levels in culture medium of neutrophils stimulated with purified Ig. G from healthy control, Jo 1 -positive sera, MDA 5 -positive sera, or without Ig. G for 1 h (n = 4). (B) MMP 9 levels in culture medium of neutrophils stimulated with purified Ig. G DOI: 10. 14336/AD. 2018. 1120 from healthy control, Jo 1 -positive sera, MDA 5 -positive sera, or without Ig. G for 3 h (n = 4). (C) MMP 9 levels in culture medium of PBMCs stimulated with purified Ig. G from healthy control, Jo 1 -positive sera, MDA 5 -positive sera, or without Ig. G for 24 h (n = 4).