In Your Future Gene DNA Editing 2 GATTACA

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In Your Future? ?

In Your Future? ?

Gene (DNA) Editing 2

Gene (DNA) Editing 2

GATTACA 3

GATTACA 3

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“The Central Dogma” of molecular biology (1957) 5

“The Central Dogma” of molecular biology (1957) 5

Human Genome Project Begins (1990) Human Genome Project Slide 6

Human Genome Project Begins (1990) Human Genome Project Slide 6

Goals of the HGP • Provide a complete and accurate sequence of the 3

Goals of the HGP • Provide a complete and accurate sequence of the 3 billion DNA base pairs of ATG&C that constitute the human genome and to identify all of the estimated 20, 000 to 25, 000 human genes that make us human; • Develop new tools to obtain, store, and analyze the data and to make this information widely available (Bioinformatics) • Explore the consequences of genomic research through its Ethical, Legal, and Social Implications (ELSI) program 7

Human Genome Project Ends (2003) 8

Human Genome Project Ends (2003) 8

~3, 000 bp (0. 0001%) of Human Genome Sequence • TGTGCGGAGTAGGGGTGGGGGGAATTGGAAGCAAATGACATCACAGCAGGTCAGAGAAAAAG GGTTGAGCGGCACCCAGAGTAGTAGGTCTTTGGCATTAGGAGCTTGAGCCCAGACGGCCCTAG CAGGGACCCCAGCGCCCGAGAGACCATGCAGAGGTCGCCTCTGGAAAAGGCCAGCGTTGTGCGGAG TAGGGGTGGGGGGAATTGGAAGCAAATGACATCACAGCAGGTCAGAGAAAAAGGGTTGAGCG

~3, 000 bp (0. 0001%) of Human Genome Sequence • TGTGCGGAGTAGGGGTGGGGGGAATTGGAAGCAAATGACATCACAGCAGGTCAGAGAAAAAG GGTTGAGCGGCACCCAGAGTAGTAGGTCTTTGGCATTAGGAGCTTGAGCCCAGACGGCCCTAG CAGGGACCCCAGCGCCCGAGAGACCATGCAGAGGTCGCCTCTGGAAAAGGCCAGCGTTGTGCGGAG TAGGGGTGGGGGGAATTGGAAGCAAATGACATCACAGCAGGTCAGAGAAAAAGGGTTGAGCG GCAGGCACCCAGAGTAGTAGGTCTTTGGCATTAGGAGCTTGAGCCCAGACGGCCCTAGCAGGGACCC CAGCGCCCGAGAGACCATGCAGAGGTCGCCTCTGGAAAAGGCCAGCGTTGTGCGGAGTAGGGGTGGGGGGAATTGGAAGCAAATGACATCACAGCAGGTCAGAGAAAAAGGGTTGAGCGGCACC CAGAGTAGTAGTCTTTGGCATTAGGAGCTTGAGCCCAGACGGCCCTAGCAGGGACCCCAGCGCCCGA GAGACCATGCAGAGGTCGCCTCTGGAAAAGGCCAGCGTTGTGCGGAGTAGGGGTGGGGGGAA TTGGAAGCAAATGACATCACAGCAGGTCAGAGAAAAAGGGTTGAGCGGCACCCAGAGTAGTA GGTCTTTGGCATTAGGAGCTTGAGCCCAGACGGCCCTAGCAGGGACCCCAGCGCCCGAGAGACCATG CAGAGGTCGCCTCTGGAAAAGGCCAGCGTTGTGCGGAGTAGGGGTGGGGGGAATTGGAAGCA AATGACATCACAGCAGGTCAGAGAAAAAGGGTTGAGCGGCACCCAGAGTAGTAGGTCTTTGGC ATTAGGAGCTTGAGCCCAGACGGCCCTAGCAGGGACCCCAGCGCCCGAGAGACCATGCAGAGGTCG CCTCTGGAAAAGGCCAGCGTTGTGCGGAGTAGGGGTGGGGGGAATTGGAAGCAAATGACATC ACAGCAGGTCAGAGAAAAAGGGTTGAGCGGCACCCAGAGTAGTAGGTCTTTGGCATTAGGAGC TTGAGCCCAGACGGCCCTAGCAGGGACCCCAGCGCCCGAGAGACCATGCAGAGGTCGCCTCTGGAA AAGGCCAGCGTTGTGCGGAGTAGGGGTGGGGGGAATTGGAAGCAAATGACATCACAGCAGGT CAGAGAAAAAGGGTTGAGCGGCACCCAGAGTAGTAGGTCTTTGGCATTAGGAGCTTGAGCCCA GACGGCCCTAGCAGGGACCCCAGCGCCCGAGAGACCATGCAGAGGTCGCCTCTGGAAAAGGCCAGC GTTGTGCGGAGTAGGGGTGGGGGGAATTGGAAGCAAATGACATCACAGCAGGTCAGAGAAAA AGGGTTGAGCGGCACCCAGAGTAGTAGGTCTTTGGCATTAGGAGCTTGAGCCCAGACGGCCCT AGCAGGGACCCCAGCGCCCGAGAGACCATGCAGAGGTCGCCTCTGGAAAAGGCCAGCGTTGTGCGG A G T A G G T G G G A A T T G G A A G C A

“Genomics” is… • Study of interactions of multiple genes with each other and with

“Genomics” is… • Study of interactions of multiple genes with each other and with the environment: --Where you live--in utero and post-partum --The air you breathe --What you eat and drink Slide 10

Genomic Medicine (2005) Healthcare tailored to an individual based on genomic information 11

Genomic Medicine (2005) Healthcare tailored to an individual based on genomic information 11

The $1, 000 Genome • ~$1, 000, 000 • ~$1, 000 12

The $1, 000 Genome • ~$1, 000, 000 • ~$1, 000 12

Genomics is… 13

Genomics is… 13

The “Big Data” Problem 14

The “Big Data” Problem 14

Ethical, Legal, and Social Issues Slide 15

Ethical, Legal, and Social Issues Slide 15

The Future: Next Generation (Exome) Screening in Newborns Question Should universal screening [e. g.

The Future: Next Generation (Exome) Screening in Newborns Question Should universal screening [e. g. , Next Generation (Exome)Screening] of newborns become a routine part of public health? If so—and a mutant gene (or genes) associated with a disease that might/might not be treatable, at what point in that child’s life should that information be divulged? http: //content. time. com/time/video/player/0, 32068, 1916421175001 _2127453, 00. html Slide 16

The Genomic Future?

The Genomic Future?