In Metabolic Syndrome Hyperinsulinism Creates the Vicious Cycle

In Metabolic Syndrome Hyperinsulinism Creates the Vicious Cycle: Increased MAP-kinase pathway Hyperinsulinism Circulation. 2005; 111: 1448 -1454. Metabolic Syndrome A Comprehensive Perspective Based on Interactions Between Obesity, Diabetes, and Inflammation. Paresh Dandona

Peripheral Insulin Resistance- Induced or Genetically-Induced Hyperinsulinemia has Adverse Downstream Effects Hyperinsulinemia et ab oli (P c p I 3 ath K) w a M Insulin. Resistance Glucose transport Hyperglycemia Glykogen synthese Obesity leads to Insulin resistance by Phosphorylating IRS-1 y wa th pa ) c ni PK ge A ito (M M y Insulin Proliferation, ENDOTHELIAL DYSFUCTION, INFLAMMATION ASVD

Vascular Effects of Function of NO vs Endothelin Vascular actions of insulin with implications for endothelial dysfunction Maria Assunta Potenza. Am J Physiol Endocrinol Metab 297: E 568–E 577, 2009.

IR and Vasculature- Nitricoxide and mitochondria in metabolic syndrome Larisa Litvinova, Frontiers in Physiology , February 2015|Volume 6|Article 20 | 1

Coronary Blood Flow Decreased and Coronary Vascular Resistance Increased with Increased Weight markers of metabolic syndrome such as BMI, HDL chol. , insulin resistance, and CRP plasma level were predictive of the alterations in MBF

Abnormalities seen with IR/ Compensatory Hyperinsulinemia: Risk Factors for ASVD