Impact of hypertensive emergency and rare complement variants

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Impact of hypertensive emergency and rare complement variants on the presentation and outcome of

Impact of hypertensive emergency and rare complement variants on the presentation and outcome of atypical hemolytic uremic syndrome by Khalil El Karoui, Idris Boudhabhay, Florent Petitprez, Paula Vieira-Martins, Fadi Fakhouri, Julien Zuber, Florence Aulagnon, Marie Matignon, Eric Rondeau, Laurent Mesnard, Jean-Michel Halimi, and Véronique Frémeaux-Bacchi haematol Volume 104(12): 2501 -2511 December 1, 2019 © 2019 by Ferrata Storti Foundation

Study flow chart. Khalil El Karoui et al. Haematologica 2019; 104: 2501 -2511 ©

Study flow chart. Khalil El Karoui et al. Haematologica 2019; 104: 2501 -2511 © 2019 by Ferrata Storti Foundation

Clinical, biological and genetic characteristics of patients with atypical hemolytic uremic syndrome with or

Clinical, biological and genetic characteristics of patients with atypical hemolytic uremic syndrome with or without hypertensive emergency. Khalil El Karoui et al. Haematologica 2019; 104: 2501 -2511 © 2019 by Ferrata Storti Foundation

Renal survival in patients with atypical hemolytic uremic syndrome, with or without hypertensive emergency,

Renal survival in patients with atypical hemolytic uremic syndrome, with or without hypertensive emergency, not treated with eculizumab. Khalil El Karoui et al. Haematologica 2019; 104: 2501 -2511 © 2019 by Ferrata Storti Foundation

Genetic characteristics of patients with atypical hemolytic uremic syndrome with or without hypertensive emergency,

Genetic characteristics of patients with atypical hemolytic uremic syndrome with or without hypertensive emergency, and of French controls. Khalil El Karoui et al. Haematologica 2019; 104: 2501 -2511 © 2019 by Ferrata Storti Foundation

Distribution of rare complement variants observed in the whole cohort. Khalil El Karoui et

Distribution of rare complement variants observed in the whole cohort. Khalil El Karoui et al. Haematologica 2019; 104: 2501 -2511 © 2019 by Ferrata Storti Foundation

Renal survival of patients treated or not with eculizumab. Khalil El Karoui et al.

Renal survival of patients treated or not with eculizumab. Khalil El Karoui et al. Haematologica 2019; 104: 2501 -2511 © 2019 by Ferrata Storti Foundation

Characteristics and outcome of patients with atypical hemolytic uremic syndrome according to the presence

Characteristics and outcome of patients with atypical hemolytic uremic syndrome according to the presence or absence of hypertensive emergency and rare complement variants. Khalil El Karoui et al. Haematologica 2019; 104: 2501 -2511 © 2019 by Ferrata Storti Foundation

Renal survival of patients with atypical hemolytic uremic syndrome according to the presence or

Renal survival of patients with atypical hemolytic uremic syndrome according to the presence or absence of rare complement variants and hypertensive emergency. Khalil El Karoui et al. Haematologica 2019; 104: 2501 -2511 © 2019 by Ferrata Storti Foundation

Variants Lex Variants or Lexicallyrelated Variants Morphological VariantsVariants Lex Variants or Lexicallyrelated Variants Morphological Variants
Complement fixation test complement fixation test The complementComplement fixation test complement fixation test The complement
2s Complement form 1s complement form 2s complement2s Complement form 1s complement form 2s complement
Common variants vs Rare variants The 1000 genomeCommon variants vs Rare variants The 1000 genome
1 Hypertensive Crises Diagnosis and Treatment Hypertensive Crises1 Hypertensive Crises Diagnosis and Treatment Hypertensive Crises
Anti Hypertensive Anti Hypertensive Types of HTN 1Anti Hypertensive Anti Hypertensive Types of HTN 1
Hypertensive crisis Hypertensive crisis SBP 210 mmhg orHypertensive crisis Hypertensive crisis SBP 210 mmhg or
1 Complement Theory 2 1s and 2s complement1 Complement Theory 2 1s and 2s complement