ImmunologyPharmacy Students Innate Immunity Lecture 4 Dr Mohammad

Immunology/Pharmacy Students Innate Immunity Lecture 4 Dr. Mohammad Odibate Department of Microbiology and immunology Faculty of Medicine, Mu’tah University

Objectives To understand the meaning of the innate immune response To study the different lines of the innate immune response To understand the interaction between the different lines of the innate immune response To study the association between NKs and innate immunity

Cytotoxic T lymphocytes vs. NK lymphocytes

Natural Killer cell NK cell Activating protein Activating signal NK cell Perforin and granzymes Inhibitory protein (Ly 49) MHC 1 (self) Normal cell Survive Tumor cell Lysis

Natural Killer cell NK cell Perforin and granzymes MHC 1 (nonself) Virally infected cell Incompatible transplanted tissue Lysis The activating in the absence of MHC 1 will activate The NK cell to release the cytolytic proteins

Natural Killer cells mediate antibody dependent mediated cell cytotoxicity (ADCC) Present these Mutated proteins to T cells APC Tumor cell produces abnormal (mutated proteins) APC uptakes cellular debris from damaged tumor cells NK cell Antibodies will be produced , released into circulation, and Eventually bind to the tumor cell Perforin and granzymes Tumor cell NK has a receptor for the antibody Fc portion Tumor cell

Innate immunity Third line defense Adaptive Immunity Target Second line defense

In case of heavy infection macrophages will migration to regional lymph nodes to activate the adaptive immune response

Levels of immunity

Innate vs. adaptive immunity

Innate vs. adaptive immunity