Immunology JongMo Seo Immunology JongMo Seo Immunology Spectral

Immunology Jong-Mo Seo

Immunology Jong-Mo Seo

Immunology Spectral Karyotyping Jong-Mo Seo

Immunology Immune system Jong-Mo Seo

Immunology Jong-Mo Seo

Immunology Jong-Mo Seo

Immunology Jong-Mo Seo

Immunology Jong-Mo Seo

Immunology Jong-Mo Seo

Immunology Complement System Jong-Mo Seo

Immunology Antibody (Immunoglobulin) Jong-Mo Seo

Immunology Antibody diversity Jong-Mo Seo

Immunology B cell maturation Jong-Mo Seo

Immunology Ig G Jong-Mo Seo

Immunology Ig E Jong-Mo Seo

Immunology Ig A Jong-Mo Seo

Immunology Boost and memory Jong-Mo Seo

Immunology Jong-Mo Seo

Immunology Jong-Mo Seo

Immunology Jong-Mo Seo

Immunology Jong-Mo Seo

Immunology Monoclonal antibody HGPRTase: hypoxanthine-guanine phosphoribosyltransferase HAT media: Hypoxanthine, aminopterin, thymine medium Jong-Mo Seo

Immunology Jong-Mo Seo Humanized antibody CDRs: Complementarity Determining Region

Immunology Jong-Mo Seo Magic bullets • For transplantation rejection anti-IL-2 R (p 55 alpha, CD 25, Tac) – Zenapax (Daclizumab): 90% human and 10% murine – Simulect (Basiliximab): 70% human and 30% murine • For Breast cancer anti HER 2/neu R (erb. B 2 R) – Herceptin (Trastuzumab) • For Non-Hdgkin’s Lymphoma anti CD 20 – Rituxan / Mab. Thera (Rituximab) • For ectoderm origin tumor anti EGFR – Nimotuzumab – Vectibix (panitumumab: Ig. G 2) – Erbitux (cetuximab: Ig. G 1) • For AMD anti VEGF – Lucentis (Ranibizumab) – Avastin (Bevacizumab) – Macugen (pegaptanib) • For autoimmune disease anti TNFalpha – Humira (Adalimumab) – Remicade (Infliximab) anti IL-1 R – Anakinra soluble TNFR – Enbrel (Etanercept) • For asthma anti Ig E – Xolair (Omalizumab)

Immunology Jong-Mo Seo

Immunology Take home message • Function of immunoglobulin • Function of T cell Jong-Mo Seo