Immunology Jeopardy Introduction to Immunology Cells and Tissues

Immunology Jeopardy

Introduction to Immunology Cells and Tissues Innate Immunity of the Immune System Cytokines $100 $200 $300 $400 $500 The $100 $200 John $200 SCORE

$100. In most cases, adaptive immune responses rely on the initial activation of _____ in secondary lymphoid tissue 30 A. B. C. D. E. Macrophages T cells B cells Dendritic cells Endothelial cells

$100. In most cases, adaptive immune responses rely on the initial activation of _____ in secondary lymphoid tissue A. B. C. D. E. Macrophages T cells B cells Dendritic cells Endothelial cells SCORE

$200. Administration of anti–rabies virus antiserum to a boy who was bitten by a rabid dog is an example of which type of treatment? A. B. C. D. Active humoral immunity Passive humoral immunity Active cell-mediated immunity Passive cell-mediated immunity 30

$200. Administration of anti–rabies virus antiserum to a boy who was bitten by a rabid dog is an example of which type of treatment? A. B. C. D. Active humoral immunity Passive humoral immunity Active cell-mediated immunity Passive cell-mediated immunity SCORE

$300 Which of the following is a unique property of the adaptive immune system? A. B. C. D. E. Recognition of microbial structures by both cellassociated and soluble receptors Responses that have the same kinetics and magnitude on repeated exposure to the same microbe Highly diverse repertoire of specificities for antigens Self-nonself discrimination Protection against viral infections 30

$300 Which of the following is a unique property of the adaptive immune system? A. B. C. D. E. Recognition of microbial structures by both cellassociated and soluble receptors Responses that have the same kinetics and magnitude on repeated exposure to the same microbe Highly diverse repertoire of specificities for antigens Self-nonself discrimination Protection against viral infections SCORE

$400 Which of the following explains why immunity to influenza may appear to be relatively short-lived? A. B. Effective immunological memory fails to develop. Immune responses to influenza involve innate immune mechanisms only. C. The primary and secondary immune responses are equivalent. D. Influenza virus targets memory cells. E. New influenza variants able to escape previous immunity appear regularly. 30

$400 Which of the following explains why immunity to influenza may appear to be relatively short-lived? A. B. Effective immunological memory fails to develop. Immune responses to influenza involve innate immune mechanisms only. C. The primary and secondary immune responses are equivalent. D. Influenza virus targets memory cells. E. New influenza variants able to escape previous immunity appear regularly. SCORE

$500 Which of the following is least soluble? A. B. C. D. E. C 3 a C-reactive protein MHC ROS IL-12 30

$500 Which of the following is least soluble? A. B. C. D. E. C 3 a C-reactive protein MHC ROS IL-12 SCORE

MHC molecules are transmembrane protein complexes Abbas Fig. 2. 11 SCORE CHECK SCORE

$100 A 20 year old woman was involved in an automobile accident that necessitated the removal of her spleen. To which of the following pathogens will she have increased susceptibility? A. B. C. D. E. Gram positive bacteria Gram negative bacteria Encapsulated bacteria Fungi Viruses 30

$100 A 20 year old woman was involved in an automobile accident that necessitated the removal of her spleen. To which of the following pathogens will she have increased susceptibility? A. B. C. D. E. Gram positive bacteria Gram negative bacteria Encapsulated bacteria Fungi Viruses SCORE

$200 Which of the following pairs is mismatched? A. B. innate immunity: highly specialized defenses lymphocyte recirculation: continuous transport between blood and lymph. C. secondary immune response: immunological memory D. Phagocytosis: uptake and killing of microbes E. Hematopoiesis: bone marrow 30

$200 Which of the following pairs is mismatched? A. B. innate immunity: highly specialized defenses lymphocyte recirculation: continuous transport between blood and lymph. C. secondary immune response: immunological memory D. Phagocytosis: uptake and killing of microbes E. Hematopoiesis: bone marrow SCORE

$300 Which of the following is present in Peyer’s patches, yet not lymph nodes? A. B. C. D. E. Dendritic cells Microfold cells Germinal centers Antigen presentation Follicles 30

$300 Which of the following is present in Peyer’s patches, yet not lymph nodes? A. B. C. D. E. Dendritic cells Microfold cells Germinal centers Antigen presentation Follicles SCORE

$400 Immune cells within the lymphatic circulation are directly deposited into which of the following anatomical sites so that the cells may reenter the bloodstream? A. B. C. D. E. Right aorta Left subclavian vein Left carotid artery High endothelial venule Hepatic vein 30

$400 Immune cells within the lymphatic circulation are directly deposited into which of the following anatomical sites so that the cells may reenter the bloodstream? A. B. C. D. E. Right aorta Left subclavian vein Left carotid artery High endothelial venule Hepatic vein SCORE

Lymphocytes named for unique ability to travel through both the lymph and the blood Parham Figure 1 -20

Circulating lymphocytes meet lymph-borne pathogens in draining lymph nodes Parham Figure 1 -20 SCORE

$500 The spleen differs from lymph nodes in which of the following? A. It filters blood as well as lymph B. It does not contain follicles C. It does not have connections with the lymphatics D. More than one, but not all E. All of the above 30

$500 The spleen differs from lymph nodes in which of the following? A. It filters blood as well as lymph B. It does not contain follicles C. It does not have connections with the lymphatics D. More than one, but not all E. All of the above SCORE CHECK SCORE

$100 Which of the following statements regarding neutrophils is false? A. B. C. D. E. Neutrophils are mobilized from the bone marrow to sites of infection when needed. Dead neutrophils are cleared from sites of infection by macrophages. Neutrophils form pus, which comprises dead neutrophils Neutrophils are active only in aerobic conditions. Neutrophils are phagocytic 30

$100 Which of the following statements regarding neutrophils is false? A. B. C. D. E. Neutrophils are mobilized from the bone marrow to sites of infection when needed. Dead neutrophils are cleared from sites of infection by macrophages. Neutrophils form pus, which comprises dead neutrophils Neutrophils are active only in aerobic conditions. Neutrophils are phagocytic SCORE

$200 Which complement pathway is typically activated by the humoral branch of adaptive immunity? A. B. C. D. Alternative pathway Classical pathway Lectin pathway All of the above 30

$200 Which complement pathway is typically activated by the humoral branch of adaptive immunity? A. B. C. D. Alternative pathway Classical pathway Lectin pathway All of the above SCORE

Pathways of complement activation Abbas Fig. 2 -12

$300 Which of the following pairs is mismatched? A. B. C. D. E. monocyte progenitor: macrophage erythroid progenitor: erythrocyte myeloid progenitor: neutrophil lymphoid progenitor: natural killer cell None of the above is mismatched. 30

$300 Which of the following pairs is mismatched? A. B. C. D. E. monocyte progenitor: macrophage erythroid progenitor: erythrocyte myeloid progenitor: neutrophil lymphoid progenitor: natural killer cell None of the above is mismatched. SCORE

HEMATOPOIESIS Majority of steps shown occur in bone marrow Monocyte Macrophage differentiation occurs in tissues where does conversion of naïve effector lymphocyte typically occur? Parham Fig. 1. 13

$400 Which of the following leukocytes is most prevalent in the blood and is first to arrive at the site of an infection? A. B. C. D. E. Mast cell Macrophage PML NK cell None of the above 30

$400 Which of the following leukocytes is most prevalent in the blood and is first to arrive at the site of an infection? A. B. C. D. E. Mast cell Macrophage PML NK cell None of the above SCORE

$500 Which of the following is an opsonin? A. B. C. D. E. C 3 b C 5 a Ig. G More than one, but not all All of the above 30

$500 Which of the following is an opsonin? A. B. C. D. E. C 3 b C 5 a Ig. G More than one, but not all All of the above SCORE

$500 Which of the following is NOT an opsonin? A. C 3 b B. C 5 a C. Ig. G 30

$500 Which of the following is NOT an opsonin? A. C 3 b B. C 5 a C. Ig. G SCORE

Opsonization –phagocytosis of microbes through binding of opsonins by macrophages -needed for clearance of encapsulated bacteria -C 3 b and Ig. G antibodies are opsonsins SCORE CHECK SCORE Figs. From Clinical Microbiology made ridiculously simple, Gladwin & Trattler

$100 A 47 year old man is suffering from chemotherapyinduced neutropenia. What therapeutic would be recommended to specifically raise the neutrophil levels if neutropenia persists after chemotherapy is discontinued? A. B. C. D. E. IL-1 IL-6 G-CSF IFNγ TNF 30

$100 A 47 year old man is suffering from chemotherapyinduced neutropenia. What therapeutic would be recommended to specifically raise the neutrophil levels if neutropenia persists after chemotherapy is discontinued? A. B. C. D. E. IL-1 IL-6 G-CSF IFNγ TNF SCORE

$200 Which of the following cytokines is NOT secreted by macrophages? A. B. C. D. E. IL-1 IL-6 IL-12 TNF- IFNγ 30

$200 Which of the following cytokines is NOT secreted by macrophages? A. B. C. D. E. IL-1 IL-6 IL-12 TNF- IFNγ SCORE

The macrophage-produced inflammatory cytokines TNF-α, IL-1 and IL-6 have a spectrum of activity Parham Fig. 3 -

$500 Which of the following interferons activate an antiviral response after TLR engagement by a viral molecule? A. B. C. D. E. IFN- Type I interferons All of the above More than one, but not all 30

$500 Which of the following interferons activate an antiviral response after TLR engagement by a viral molecule? A. B. C. D. E. IFN- Type I interferons All of the above More than one, but not all SCORE

Toll Like Receptor Signaling SCORE Abbas Fig. 2. 4