Imatinib and spironolactone suppress hepcidin expression by Katarzyna

Imatinib and spironolactone suppress hepcidin expression by Katarzyna Mleczko-Sanecka, Ana Rita da Silva, Debora Call, Joana Neves, Nikolai Schmeer, Georg Damm, Daniel Seehofer, and Martina U. Muckenthaler haematol Volume 102(7): 1173 -1184 June 26, 2017 © 2017 by Ferrata Storti Foundation

Two-step validation RNAi assays identify six novel hepcidin regulators. Katarzyna Mleczko-Sanecka et al. Haematologica 2017; 102: 1173 -1184 © 2017 by Ferrata Storti Foundation

Drugs targeting hepcidin regulators identified by an RNAi screen. Katarzyna Mleczko-Sanecka et al. Haematologica 2017; 102: 1173 -1184 © 2017 by Ferrata Storti Foundation

Drugs identified as hepcidin modulators in Huh 7 cells and primary hepatocytes. Katarzyna Mleczko-Sanecka et al. Haematologica 2017; 102: 1173 -1184 © 2017 by Ferrata Storti Foundation

Summary of drug targets and drugs identified as hepcidin modulators in hepatocytic cellular models. Katarzyna Mleczko-Sanecka et al. Haematologica 2017; 102: 1173 -1184 © 2017 by Ferrata Storti Foundation

Refinement of drug target-drug relationships. Katarzyna Mleczko-Sanecka et al. Haematologica 2017; 102: 1173 -1184 © 2017 by Ferrata Storti Foundation

Blood parameters in mice treated with hepcidin-modifying drugs. Katarzyna Mleczko-Sanecka et al. Haematologica 2017; 102: 1173 -1184 © 2017 by Ferrata Storti Foundation

Treatment with imatinib and spironolactone suppresses hepcidin in mice. Katarzyna Mleczko-Sanecka et al. Haematologica 2017; 102: 1173 -1184 © 2017 by Ferrata Storti Foundation