Image from www interactivebiology com Skeletal System Inside

Image from: www. interactive-biology. com Skeletal System Inside look at the BONES

Parts of the Skeletal System Bones (Skeletal organ) Joints Cartilage Ligaments Tendons

Types of Bones are classified by their structure each vary in proportions of compact and cancellous. Long Short Flat Irregular Sesamoid

Short, Flat, Irregular, Sesamoid Short Flat Broad and thin with flattened and curved surface Filled with marrow Example: Sternum Irregular Cube or boxed shaped Examples: Carpals and Tarsals Misshaped bones found in groups Examples vertebral and facial bones Sesamoid Found in locations where a tendon passes a joint Example: patella

Long Bones Known for its length and distinct structures Diaphysis Main shaft of a long bone Hollow, cylindrical shape and thick compact bone Function is to provide strong support without cumbersome weight Epiphyses Both ends of a long bone; made of cancellous bone filled with marrow Function is to provide attachments for muscles and give stability to joints

Long Bone (continued) Articular cartilage Layer of hyaline cartilage that covers the articular surface of epiphyses Function is to cushion jolts and blows Periosteum Dense, white fibrous membrane that covers bone Attaches tendons firmly to bones Contains blood vessels essential for bone cell survival and bone formation

Long Bone (continued) Medullary (or marrow) cavity Endosteum: Thin, fibrous membrane that lines the medullary cavity Sharpey’s fibers Tubelike, hollow space in the diaphysis Filled with yellow marrow in adults Secure periosteum to underlying bone Arteries Supply bone cells with nutrients

Anatomy of the Long Bone spongy bone Proximal compact bone epiphysis diaphysis Endosteum epiphyseal line yellow marrow Sharpey’s fibers Distal epiphysis hyaline cartilage periosteum

Bone Tissues Most distinctive form of connective tissue Composition Inorganic salts ( calcium, phosphate, magnesium and sodium) Organic matrix (collagenous fibers, proteins and polysaccharides, glucosamine) Two basic types Compact Bone Spongy Bone

Compact Bone Contains many cylinder-shaped structural units called osteons, or haversian systems Osteons surround haversian canals that run lengthwise through bone and are connected by transverse (Volkmann) canals Living bone cells are located in osteon Osteons permit delivery of nutrients and removal of waste products

Structures of Osteon Lamella- concentric calcified matrix Lacunae- spaces filled with tissue fluid between lamella Canaliculi- ultra small canals that connect lacunae and harvesian canals Gray’s Anatomy of the Human Body from the classic 1918 publication Harvesian canals- contain blood vessels and lymphatic vessels

Cancellous (Spongy) Bone No osteons in cancellous bone; it has trabeculae instead Nutrients are delivered and waste products removed by diffusion through tiny canaliculi Bony branches (trabeculae) are arranged along lines of stress to enhance the bone’s strength

Types of Bone Cells Osteocytes Osteoblasts Mature bone cells Bone-forming cells Osteoclasts Bone-destroying cells Break down bone matrix for remodeling and release of calcium Bone remodeling is a process by both osteoblasts and osteoclasts

Blood supply Bone cells are metabolically active and need a blood supply Supplied from bone marrow Bone marrow and blood vessels penetrates the bone and then, by way of transverse (Volkmann) canals, connects with vessels in the central canals of osteons

Bone Marrow Composition Function Myoloid- soft connective tissue Site of for production of blood cells; hematopoises Location Medullary cavities of long bones Empty spaces of spongy bone

Types of Marrow Red marrow Found in virtually all bones in an infant’s or child’s body Produces red blood cells Yellow marrow As an individual ages, red marrow is replaced by yellow marrow Marrow cells become saturated with fat and are no longer active in blood cell production

Bones Function Support- form the framework that supports the body and cradles soft organs. Protection- provides a protective case for brain, spinal cord and vital organs Movement- provides levers for muscles Mineral Storage- reservoir for minerals especially calcium Blood cell formation- hematopoiesis occurs in the within the marrow cavities of the bones

Calcium levels 98% calcium in the body is found in bones Calcium levels change as a result of bone remodeling. Homeostasis of calcium ion concentration affects several functions Bone formation, remodeling and repair Blood clotting Trasmission of nerve impulses Cardiac and skeletal muscle contractions

Mechanism of Calcium Homeostasis Parathyroid hormone Primary regulator of calcium homeostasis Calcitonin Protein hormone produced in the thyroid gland Produced in response to high blood calcium levels

Bone Development Osteogenesis development of bone small cartilage model to adult model Endochondral ossification Bone formation spreading essentially from the center to the ends Replacement of hyaline cartilage

From cartilage to bone Cartilage cells (chondrocytes) begin to die, region becomes known as the ossification center Primary- middle of diaphysis Secondary- epiphysis Periosteum is forming around the outside of the cartilaginous model. Periosteum produces osteoblast Osteoblasts build up on the periphery of the spongy bone, they secrete their matrix and build compact bone all around the spongy bone. This occurs simultaneously

The Growing Bone Epiphyseal plate remain between diaphysis and both epiphysis. Its is composed of 4 layers “Resting” cartilage cells. Zone of proliferationcartilage cells undergoing mitosis Zone of hypertrophy- older cells undergoing degenerative changes Zone of Calcification- dead cartilage cells undergoing calcification Osteoclast widen the medullary cavity Osteoblast build new bone around existing bone

Cartilage Characteristics Avascular connective tissue Fibers of cartilage are embedded in a firm gel Has the flexibility of firm plastic No canal system or blood vessels Functions Tough, rubberlike nature permits cartilage to sustain great weight or serve as a shock absorber Strong yet pliable support structure Permits growth in length of long bones

Types of Cartilage Hyaline cartilage Elastic cartilage Most common type Covers the articular surfaces of bones Forms external ear, epiglottis, and eustachian tubes Fibrocartilage Occurs in pubic symphysis and intervertebral disks Strong and rigid

Bone Fractures Fracture—break in a bone Types of bone fractures Closed (simple) fracture—break that does not penetrate the skin Open (compound) fracture—broken bone penetrates through the skin Bone fractures are treated by reduction and immobilization

Common Types of Fractures Table 5. 2

Bone repair Healing 1. Fractures destroy blood vessels 2. Vascular damage initiates repair 3. Dead bone is removed by osteoclastic resorption 4. Fracture hematoma(blood clot cause duiring break) is reabsorbed and callus ( Specialized repair tissue) is deposited in bones