Identification Screening Eligibility Included Records identified through database

Identification Screening Eligibility Included Records identified through database searching (n=207) Additional records identified through other sources (n=10) Records identified (n=217) Duplicated records excluded (n=57) Records after duplicates removed (n=160) Excluded by title and abstract (n=59) Full-text articles assessed for eligibility (n=101) Studies included in current meta-analysis (n=24) Twenty intervention arms Articles (n=77) excluded according to (1) Not randomized-controlled trials (2) Not human clinical trials (3) Lack of adequate control (4) Duplicated database from other studies (5) Insufficient data despite of request (6) Review/meta-analysis (7) Protocol but not trials result (8) Not related to prevention to outcome of bacteremia Figure 1 The flowchart of the current network meta-analysis

Individual figure Legends Figure 1 depicted the whole flowchart of current network meta-analysis

Odds ratio with 95%CI less incidence of bacteremia by preventive management less incidence of bacteremia by placebo/control Figure 2 Forest plot of network meta-analysis of incidence of bacteremia after overall dental procedure

Individual figure Legends Figure 2 indicated that, when ES < 1, it meant less incidence of bacteremia by preventive management than placebo/control groups did. Abbreviation: chlorhexidine: rinse chlorhexidine; CI: confidence interval; control: control/placebo; essentialoil: rinse essential oil–containing antiseptic; i 15 cefuroxime: IV 1. 5 g cefuroxime; i 1 amoxycillin: IM 1 g amoxycillin; i 4 teicoplanin: IV 400 mg teicoplanin; i 5 amoxicillin: IV 50 mg/kg amoxicillin in children; iamclavulanate: IV 1000/200 mg amoxicillin/clavulanate; IM: intramuscular; IV: intravenous; o 15 erythromycin: oral 1. 5 g erythromycin; o 1 cefaclor: oral 1 g cefaclor; o 1 erythromycin: oral 1 g erythromycin; o 2 amoxicillin: oral 2 g amoxicillin; o 2 penicillin: oral 2 g penicillin; o 3 amoxicillin: oral 3 g amoxicillin; o 4 moxifloxacin: oral 400 mg moxifloxacin; o 5 azithromycin: oral 500 mg azithromycin; o 6 clindamycin: oral 600 mg clindamycin; ojosamycin: oral 1. 5 g josamycin; povidone: rinse povidone-iodine solution; topamoxicillin: rinse amoxicillin suspension

Odds ratio with 95%CI Treatment effect iamclavulanate o 4 moxifloxacin o 15 erythromycin o 5 azithromycin o 1 erythromycin less incidence of bacteremia by preventive management less incidence of bacteremia by placebo/control Figure 3 Forest plot of network meta-analysis of incidence of bacteremia after dental extraction

Individual figure Legends Figure 3 indicated that, when ES < 1, it meant less incidence of bacteremia by preventive management than placebo/control groups did. Abbreviation: chlorhexidine: rinse chlorhexidine; CI: confidence interval; control: control/placebo; essentialoil: rinse essential oil–containing antiseptic; i 15 cefuroxime: IV 1. 5 g cefuroxime; i 1 amoxycillin: IM 1 g amoxycillin; i 4 teicoplanin: IV 400 mg teicoplanin; i 5 amoxicillin: IV 50 mg/kg amoxicillin in children; iamclavulanate: IV 1000/200 mg amoxicillin/clavulanate; IM: intramuscular; IV: intravenous; o 15 erythromycin: oral 1. 5 g erythromycin; o 1 cefaclor: oral 1 g cefaclor; o 1 erythromycin: oral 1 g erythromycin; o 2 amoxicillin: oral 2 g amoxicillin; o 2 penicillin: oral 2 g penicillin; o 3 amoxicillin: oral 3 g amoxicillin; o 4 moxifloxacin: oral 400 mg moxifloxacin; o 5 azithromycin: oral 500 mg azithromycin; o 6 clindamycin: oral 600 mg clindamycin; ojosamycin: oral 1. 5 g josamycin; povidone: rinse povidone-iodine solution; topamoxicillin: rinse amoxicillin suspension

Odds ratio with 95%CI less incidence of bacteremia by preventive management less incidence of bacteremia by placebo/control Figure 4 Forest plot of network meta-analysis of incidence of bacteremia after dental procedure in adult participants only

Individual figure Legends Figure 4 indicated that, when ES < 1, it meant less incidence of bacteremia by preventive management than placebo/control groups did. Abbreviation: chlorhexidine: rinse chlorhexidine; CI: confidence interval; control: control/placebo; essentialoil: rinse essential oil–containing antiseptic; i 15 cefuroxime: IV 1. 5 g cefuroxime; i 1 amoxycillin: IM 1 g amoxycillin; i 4 teicoplanin: IV 400 mg teicoplanin; i 5 amoxicillin: IV 50 mg/kg amoxicillin in children; iamclavulanate: IV 1000/200 mg amoxicillin/clavulanate; IM: intramuscular; IV: intravenous; o 15 erythromycin: oral 1. 5 g erythromycin; o 1 cefaclor: oral 1 g cefaclor; o 1 erythromycin: oral 1 g erythromycin; o 2 amoxicillin: oral 2 g amoxicillin; o 2 penicillin: oral 2 g penicillin; o 3 amoxicillin: oral 3 g amoxicillin; o 4 moxifloxacin: oral 400 mg moxifloxacin; o 5 azithromycin: oral 500 mg azithromycin; o 6 clindamycin: oral 600 mg clindamycin; ojosamycin: oral 1. 5 g josamycin; povidone: rinse povidone-iodine solution; topamoxicillin: rinse amoxicillin suspension

Odds ratio with 95%CI less incidence of bacteremia by preventive management less incidence of bacteremia by placebo/control Figure 5 Forest plot of network meta-analysis of incidence of bacteremia after dental procedure in situation of local anesthesia

Individual figure Legends Figure 5 indicated that, when ES < 1, it meant less incidence of bacteremia by preventive management than placebo/control groups did. Abbreviation: chlorhexidine: rinse chlorhexidine; CI: confidence interval; control: control/placebo; essentialoil: rinse essential oil–containing antiseptic; i 15 cefuroxime: IV 1. 5 g cefuroxime; i 1 amoxycillin: IM 1 g amoxycillin; i 4 teicoplanin: IV 400 mg teicoplanin; i 5 amoxicillin: IV 50 mg/kg amoxicillin in children; iamclavulanate: IV 1000/200 mg amoxicillin/clavulanate; IM: intramuscular; IV: intravenous; o 15 erythromycin: oral 1. 5 g erythromycin; o 1 cefaclor: oral 1 g cefaclor; o 1 erythromycin: oral 1 g erythromycin; o 2 amoxicillin: oral 2 g amoxicillin; o 2 penicillin: oral 2 g penicillin; o 3 amoxicillin: oral 3 g amoxicillin; o 4 moxifloxacin: oral 400 mg moxifloxacin; o 5 azithromycin: oral 500 mg azithromycin; o 6 clindamycin: oral 600 mg clindamycin; ojosamycin: oral 1. 5 g josamycin; povidone: rinse povidone-iodine solution; topamoxicillin: rinse amoxicillin suspension

Figure legends for appendix e. Figure 1 A-1 E: The lines between nodes represent direct comparisons in various trials, and the size of each circle is proportional to the size of the population involved in each specific treatment. The thickness of the lines is proportional to the number of trials connected to the network. Abbreviation: chlorhexidine: rinse chlorhexidine; CI: confidence interval; control: control/placebo; essentialoil: rinse essential oil–containing antiseptic; i 15 cefuroxime: IV 1. 5 g cefuroxime; i 1 amoxycillin: IM 1 g amoxycillin; i 4 teicoplanin: IV 400 mg teicoplanin; i 5 amoxicillin: IV 50 mg/kg amoxicillin in children; iamclavulanate: IV 1000/200 mg amoxicillin/clavulanate; IM: intramuscular; IV: intravenous; o 15 erythromycin: oral 1. 5 g erythromycin; o 1 cefaclor: oral 1 g cefaclor; o 1 erythromycin: oral 1 g erythromycin; o 2 amoxicillin: oral 2 g amoxicillin; o 2 penicillin: oral 2 g penicillin; o 3 amoxicillin: oral 3 g amoxicillin; o 4 moxifloxacin: oral 400 mg moxifloxacin; o 5 azithromycin: oral 500 mg azithromycin; o 6 clindamycin: oral 600 mg clindamycin; ojosamycin: oral 1. 5 g josamycin; povidone: rinse povidone-iodine solution; topamoxicillin: rinse amoxicillin suspension

e. Figure 1 A Network structure of network meta-analysis of incidence of bacteremia after overall dental procedure

e. Figure 1 B Network structure of network meta-analysis of incidence of bacteremia after dental extraction

e. Figure 1 C Network structure of network meta-analysis of incidence of bacteremia after dental procedure in adult participants only

e. Figure 1 D Network structure of network meta-analysis of incidence of bacteremia after dental procedure in situation of local anesthesia

e. Figure 1 E Network structure of network meta-analysis of incidence of bacteremia after dental procedure in situation of general anesthesia

Figure legends for appendix e. Figure 2: e. Figure 2 indicated that, when ES < 1, it meant less incidence of bacteremia by preventive management than placebo/control groups did. Abbreviation: chlorhexidine: rinse chlorhexidine; CI: confidence interval; control: control/placebo; essentialoil: rinse essential oil–containing antiseptic; i 15 cefuroxime: IV 1. 5 g cefuroxime; i 1 amoxycillin: IM 1 g amoxycillin; i 4 teicoplanin: IV 400 mg teicoplanin; i 5 amoxicillin: IV 50 mg/kg amoxicillin in children; iamclavulanate: IV 1000/200 mg amoxicillin/clavulanate; IM: intramuscular; IV: intravenous; o 15 erythromycin: oral 1. 5 g erythromycin; o 1 cefaclor: oral 1 g cefaclor; o 1 erythromycin: oral 1 g erythromycin; o 2 amoxicillin: oral 2 g amoxicillin; o 2 penicillin: oral 2 g penicillin; o 3 amoxicillin: oral 3 g amoxicillin; o 4 moxifloxacin: oral 400 mg moxifloxacin; o 5 azithromycin: oral 500 mg azithromycin; o 6 clindamycin: oral 600 mg clindamycin; ojosamycin: oral 1. 5 g josamycin; povidone: rinse povidone-iodine solution; topamoxicillin: rinse amoxicillin suspension

Odds ratio with 95%CI e. Figure 2 forest plot of network meta-analysis of incidence of bacteremia after dental procedure in situation of general anesthesia

e. Figure 3 A overview of risk of bias

e. Figure 3 B detailed risk of bias in each study

e. Figure 4 A Funnel plot of network meta-analysis of overall dental procedure

e. Figure 4 B Egger’s regression of network meta-analysis of overall dental procedure

e. Figure 4 C Funnel plot of network meta-analysis of dental extraction only

e. Figure 4 D Egger’s regression of network meta-analysis of dental extraction only

e. Figure 4 E Funnel plot of network meta-analysis of dental procedure in adult participants

e. Figure 4 F Egger’s regression of network meta-analysis of dental procedure in adult participants

e. Figure 4 G Funnel plot of network meta-analysis of dental procedure in local anesthesia

e. Figure 4 H Egger’s regression of network meta-analysis of dental procedure in local anesthesia

e. Figure 4 I Funnel plot of network meta-analysis of dental procedure in general anesthesia

e. Figure 4 J Egger’s regression of network meta-analysis of dental procedure in general anesthesia