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ICTR Biostatistics Research Resource Mary Lindstrom Professor, Dept. of Biostatistics and Medical Informatics Director, ICTR Biostatistics Research Resource Faculty and Staff 20 UW Faculty Biostatisticians 8 UW Staff Biostatisticians 4 Marshfield Clinic Biostatisticians
ICTR Biostatistics Resource Faculty and Staff Clinical Research • UW Faculty: AC Andrei, T Becker, K Buhr, R Chappell, T Cook, M Detry, NM Dowling, M Fisher, P Hutson, R Gangnon, M Lindstrom, M Palta, M Rosenberg, S Wang • UW Staff: J Barnet, M Evans, S Hetzel, Z Li, V Rajamanickam, S Seo • Marshfield Clinic: R Berg, P Chyou, H Liang Statistical Genetics • • • UW Faculty: K Broman, S Keles, C Kendziorski, R Mau, M Newton, S Wang, B Yandell UW Staff: A Andrei, A Broman Marshfield Clinic: Z Ye
Areas of Expertise Traditional Areas • Clinical Trials • Prospective Cohort Studies • Case Control Studies • Retrospective Studies • Pre-clinical Studies Special Areas (growing, unique) • Statistical Genetics • Qualitative Outcomes • Cost and Policy Issues • Pharmacokinetics & Pharmacodynamics
Biostatistics Resource Activities Consulting Collaborative Research Methodology Research Training Protocol & Pilot Project Review
UW - Madison Resource Funding Model 13. 8 FTEs devoted to ICTR Biostatistics
Leveraging UW ICTR Resources Funding Source Activity ICTR Departments Collab. & Centers Grants (3. 7 FTE) (2. 9 FTE) Consulting X X Collaboration X X Methodology Review X Method. Grants (5. 4 FTE) (1. 9 FTE) X X
Marshfield Clinic Funding Model Funding Source FTEs Collaborative Projects 2. 10 Institutional Support 0. 10 ICTR 0. 25 2. 45 FTEs devoted to ICTR Biostatistics
Prioritizing Requests All requests must: • come from ICTR Members • be related to clinical and/or translational research Marshfield Clinic • External, large grant proposals • Internal proposals • Deadlines given priority UW - Madison When we have a waiting list: • New investigators over established • Projects leading to proposals for funding • One active project per investigator • Deadlines given priority • First come, first serve Long term management: • Departments, centers, and investigators with substantial use are asked to provide direct funding.
Units Using Resource Madison Medical School • Anatomy • Anesthesiology • Dermatology • Family Medicine • Medical Physics • Medicine • Neurological Surgery • Neurology • Obstetrics and Gynecology • Ophthalmology & Visual Sciences • Orthopedics and Rehabilitation • Pathology and Laboratory Medicine • Pharmacology • Pediatrics • Population Health Sciences • Psychiatry • Radiology • Surgery Other Schools • Agricultural and Life Sciences • Education • Engineering • Human Ecology • Library and Information Studies • Letters and Science • Nursing • Pharmacy • Veterinary Medicine Other Marshfield • Waisman Center • Cardiology • Center for Health Enhancement Systems Studies • Dermatology • Office of Continuing Professional Development in Medicine and Public Health • Internal Medicine • Department of Veterans Affairs • Division of Education • Neurology • Oncology • Pediatrics • Rheumatology • Sleep Lab • Surgery Red indicates funding for individual statisticians
ICTR Biostatistics 2009 Activity UW - Madison Marshfield Clinic 407 Projects 79 275 Investigators 36 90 Collaborative Publications 10 28 Collaborative Grants 56 50 Protocols Reviewed 59 88 Pilot Projects Reviewed
The Future • Upgrade the Activity Tracking System to follow: – the life cycle of grants, protocols, manuscripts, – the effect of training and collaboration on investigator success. • Increase capacity for qualitative endpoints collaboration. • Encourage junior Biostatistics faculty to compete for ICTR pilot grants. • Improve interaction between UW and Marshfield Clinic Biostatistics Research Resources.
Examples of Collaboration Clinical Trials Wisconsin Network for Health Research (Wi. NHR) presented by Mary Lindstrom Stat-Gen Statistical Genetics and Genomics Program presented by Christina Kendziorski
Wisconsin Network for Health Research (Wi. NHR) • A statewide network of clinical sites to collaborate on trials of • Diagnostic, preventative and therapeutic interventions • Comparative effectiveness • Expands capabilities of Wisconsin researchers • More studies done faster • Population of > 3 million • Centralizes some aspects of the research • Data management • IRB approval process • Statistical analysis • Each site has a PI and local research staff
Wi. NHR Sites Marshfield Clinic Gundersen Lutheran UW-Madison Aurora Health Care
Wi. NHR Studies • Protocols • come from all participating sites • are funded independently • Studies • 9 ongoing, 1 completed • 712 patients accrued • 8 different lead investigators • 9/10 studies use 3 or 4 sites.