Ibogaine and cellular metabolism Traditional use of Iboga
Ibogaine and cellular metabolism
Traditional use of Iboga w enteogen - ritual drug w oneirogen - awake dreams w psychostimulant and tonic w reconvalescence after infectious diseases w aphrodisiac
Use of Iboga/ibogaine in the West w interruption of addiction to alcohol, opiates, nicotine in cocaine w spiritual growth and self -realization w holly sacrament w use at extreme sports – mountaineering w interesting for army
Ibogaine in medicine w 1905: 10– 30 mg per day against asthenia w 1939 -1970: neuromuscular stimulant 8 mg per pill against fatigue, depression and at reconvalescence after infectious diseases w 1969: 4 -5 mg/kg as fantasy enhancer at psychotherapy
Pharmacodynamics of ibogaine w immediate (acute) effect w prolonged effect
Pharmacodynamics of ibogaine w effects last longer than the presence of ibogaine in the body w fat deposits of lipophillic metabolite cannot directly cause the effect for weeks or months w functional and structural changes are expected
Composition of cell • nucleic acids • proteins • polysaccharides • lipids • water
Proteins • structural • functional
Structural proteinscytoskeleton
Functional proteinsreceptor
Functional proteinsenzyme
Protein separation by 2 -D electrophoresis
Computer scan of gel
Computer scan of gel
“In silico” analysis of results
Spots of interest
Peptide mapping by mass spectrometry
Identification of proteins by matching with data bases
Induction of energy metabolism related enzymes in rat brain Enzyme Fold 24 h Fold 72 h Mr(Da)/p. I Score Peptide matching 1. 13 3. 21 36090/8. 14 62 9 Malate dehydrogenase 1. 42 3. 64 36117/8. 79 54 9 Aldolase 1. 23 2. 45 39783/8. 05 60 9 Pyruvate kinase 1. 38 2. 94 58314/7. 19 70 10 Glyceraldehyde 3 -phosphate dehydrogenase
Induction of energy metabolism related enzymes
Nonspecific activation of metabolism
Interpretation of results Enhanced energy availability supports higher metabolic turnover and by that facilitates detoxification and renewal of tissues. Besides, consequent mental agility provides insight into one’s own psychological state
Aura and ibogaine -40 min +3 h +54 h
Aura and ibogaine
Aura and ibogaine – thantanosis
Aura and ibogaine
Aura and ibogaine
Aura and ibogaine Maybe illumination and revelation are proper words to describe what is at this moment difficult to explain
Pharmacodynamics of Entheogen Drugs Influence on Gene Expression - Faculty of Pharmacy, UL - Biotechnical Faculty, UL - Faculty of Medicine, UL - Faculte de Pharmacie, Universite Montpellier 1, Montpellier, France - Institute for Biological Research Siniša Stankovic, Belgrade, Serbia OMI, Institute of Anthropological Medicine www. omi. si
- Slides: 29