IAS Towards an HIV Cure Sharon R Lewin

IAS Towards an HIV Cure Sharon R Lewin AO, FRACP Ph. D FAHMS Co-chair, Scientific Advisory Board, IAS Towards a Cure www. iasociety. org

Sunnylands initiative for an HIV cure IAS Cure Research Academies www. iasociety. org

The Annenberg Trust at Sunnylands is an independent nonpartisan, nonprofit organization dedicated to convening global leaders in the public and private sectors to promote world peace, facilitate international agreement, and seek solutions to the most daunting challenges facing the world today. www. iasociety. org

• Host: IAS in partnership with the Annenberg Trust at Sunnylands Retreat Feb 2019 • Objective: To consider what it will take to develop and ensure the widest possible access to a cure for HIV, specifically in sub-Saharan Africa. • Goals: – To align on a Target Product Profile for an HIV Cure – To agree what it will take to ensure that a cure with this profile is widely accessible to the largest number of people in sub-Saharan Africa. www. iasociety. org

What we discussed? www. iasociety. org

Current and future landscape for HIV c. ART Long-acting ART We are here Broadly neutralizing antibodies First generation Second generation Third generation Daily treatment modalities 2019 Long acting treatment modalities 20? ? Single shot cure Cure modalities 20? ? www. iasociety. org

Target populations to consider suppressed on ART viremic on ART diagnosed not treated not diagnosed at risk www. iasociety. org

Target Product Profile (TPP) • Help to align all stakeholders by broadly defining the regimen or product the community wants to deliver to the field • Form the “north star” and define the minimally-acceptable and optimistic interventions • Will evolve based on breakthrough scientific developments and changing patient needs www. iasociety. org

Towards a public private partnership for an HIV Cure: HIV Cure Acceleration of Africa (HCAAP) is a public private partnership established to drive and coordinate endto-end progress towards the goal of an HIV cure across all relevant stakeholders www. iasociety. org

Next steps and timelines Co-chaired by Dr. Sharon Lewin and Dr. Steven Deeks TPP WG established Q 3 2019: Draft cure TPPs complete We are here Q 4 2019: Socialize TPPs broadly including ICASA 2019 HCAAP WG established Q 1 2020: Conduct Delphi exercise to finalize TPPs Q 2 2020: Publish TPPs and determine longterm maintenance strategy 2020 Q 3 2019: Draft concept note complete + F 2 F meeting Q 4 2019: Socialize HCAAP concept broadly including ICASA 2019 Q 1 -2 2020: Seek funding for HCAAP Co-chaired by Dr. Izukanji Sikazwe and Dr. Mark Dybul www. iasociety. org

Acknowledgements • Bill & Melinda Gates Foundation • Cathy Bansbach • Timothy Attoye • Adam Jiang • Mike Mc. Cune • International AIDS Society • Rosanne Lamplough • Roger Tatoud • The Annenberg Foundation Trust at Sunnylands – Rob Fallon – David Lane • Mc. Kinsey & Company – Matt Craven – Matt Wilson • Sunnylands working group – Mark Dybul – Rosanne Lamplough – Ellen La. Pointe – Sharon Lewin – Steve Deeks – Mike Mc. Cune – Joe Tucker – Wendy Wertheimer www. iasociety. org

Research-for-Cure Academy www. iasociety. org

Research-for-Cure Academy 7 -9 November 2019 Wits Rural Facility, South Africa ü Are you an early to mid-career HIV investigator or clinical scientist? ü Are you affiliated with or working in collaboration with an institution or university in a resource-limited country? ü Are you interested in pursuing HIV cure research? • Deadline for applications: 12 August www. iasociety. org

Advocacy-for-Cure Academy In partnership with: www. iasociety. org

Advocacy-for-Cure Academy 29 April – 1 May 2019 Botswana Objectives: • Provide training and skills building on current HIV cure research strategies, barriers to a cure, and communicating scientific results accurately, especially to communities. • Develop translational tools to disseminate information to the wider community, including policy makers, the media and programme managers. • Create opportunities to interact with leading researchers and advocates in the field with a view to expanding the network of advocates working in HIV cure. In partnership with: www. iasociety. org