IAS 2017 IASconference Rapporteur Report Track A Basic
#IAS 2017 | @IAS_conference Rapporteur Report – Track A Basic and Translational Sciences Mathias Lichterfeld, M. D. , Ph. D. Associate Professor of Medicine Brigham and Women’s Hospital Harvard Medical School no relevant conflicts of interest or other disclosures
#IAS 2017 | @IAS_conference The number of identical HIV-DNA sequence expansions increases over time in peripheral blood Lee/Palmer et al, Abstract MOAA 0105
#IAS 2017 | @IAS_conference Defective proviruses can encode for HIV-1 protein Imamichi/Lane et al, Abstract MOPDA 0102
#IAS 2017 | @IAS_conference HIV-specific CD 8+ T cells in early treated subjects are more functionally competent Tetramer Early treated Untreated IFN-gamma Tetramer CD 8 IFN-gamma Nkosi/Ndhlovu et al, Abstract TUAA 0101
#IAS 2017 | @IAS_conference het. IL-15 Treatment Increases SIV-specific T Cells Within the Lymph Nodes CD 3+ T lymphocytes in LN Untreated het. IL-15 CM 9 Tetramer+ 0. 3 Cytotoxic Potential Tetramer+ 2. 5 Granzyme B Expansion CD 8 Valentin/Pavlakis et al, Abstract TUPDA 0103 Ki 67 Untreated het. IL-15
#IAS 2017 | @IAS_conference het. IL-15 Treatment Increases SIV-specific T Cells Within the Lymph Nodes germinal center Pre-ALT 803 Post-ALT 803 Webb/Sacha et al, Abstract TUPDA 0104
#IAS 2017 | @IAS_conference Plasma viremia in SIV-infected NHP after treatment with ART and a 4/b 7 antibodies or control Fauci et al, Presentation MOSS 0102
#IAS 2017 | @IAS_conference Viral control following a 4 b 7 antibody infusion is Likely mediated by cellular immune responses Fauci et al, Presentation MOSS 0102
#IAS 2017 | @IAS_conference Prolonged HIV-1 control after perinatal infection “The South African Baby” • • • HIV-1 DNA detectable at 32 days of life Initiated AZT/3 TC/LPV/r at 8. 5 weeks of life Interrupted ART after 40 weeks 3 -monthly f/u Undetectable VL after 8. 75 years off ART on stored and current specimens No protective HLA class I alleles Weak HIV-specific T/B cell responses 5 HIV DNA copies/ million CD 4 T cells VOA negative x 2 Violari/Tiemessen et al, Abstract TUPDB 0106 LB
#IAS 2017 | @IAS_conference Delayed viral rebound after treatment during hyperacute HIV-1 infection Participant A: • Underwent ATI after 34 months of ART • Latent reservoir size ≈200 cells prior to ATI • ≈1% of individuals with a similar HIV burden may achieve lifelong ART-free remission Henrich/Deeks et al, Abstract TUPDB 0103
#IAS 2017 | @IAS_conference Effects of therapeutic vaccination in ART-treated HIV patients on viral rebound kinetics Fauci et al, Presentation MOSS 0102
#IAS 2017 | @IAS_conference Therapeutic vaccination has no effect on viral rebound kinetics or viral reservoir markers Fauci et al, Presentation MOSS 0102
#IAS 2017 | @IAS_conference Viral reservoir biomarkers represent predictors of viral rebound kinetics Fauci et al, Presentation MOSS 0102
#IAS 2017 | @IAS_conference Many thanks! Nancie Archin, Ph. D Univ of North Carolina, Chapel Hill Anni Winckelman, MD Caroline Pereira Univ of Aarhus, Bittencourt Passes, Ph. D Denmark Institute Pasteur, Paris
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