IAS 2017 IASconference MOPDB 0101 More and earlier

#IAS 2017 | @IAS_conference #MOPDB 0101 More and earlier cardiovascular events (CVE) and shorter overall survival (OS) in HIV-positive patients (HIV+) compared to the general population differ by sex Stefan Esser 1, Marina Arendt 2, Robert Jablonka 1, Christina Schulze 1, Volker Holzendorf 3, Norbert H. Brockmeyer 4, Karl-Heinz Jöckel 2, Raimund Erbel 2, Nico Reinsch 5 on behalf of HIV HEART Study Group and Heinz Nixdorf Recall Investigative Group 1 Clinic of Dermatology, Department of Venereology, University Hospital Essen, Germany 2 Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Germany 3 Clinical Trial Centre Leipzig - Coordination Centre for Clinical Trials (ZKS Leipzig - KKS), University Leipzig, Germany 4 Germany Clinic of Dermatology, Center for Sexuell Health and Medizin Ruhruniversity Bochum, Germany 5 Department of Internal Medicine I and Cardiology, Devision of Electrophysiology, Alfried Krupp Hospital, Essen, Germany

#MOPDB 0101 #IAS 2017 | @IAS_conference More and earlier cardiovascular events (CVE) and shorter overall survival (OS) in HIV-positive patients (HIV+) compared to the general population differ by sex Conflict of Interest • Research Grant: – BMS, Gilead, GSK, Janssen, MSD, Vii. V • Scientific council: – Abb. Vie, BMS, Gilead, Janssen, MSD, Vii. V • Honorary lecturer: – Abb. Vie, BMS, Gilead, Janssen, MSD, Vii. V • Financial participation in the course of a business: NONE • Seminars and conferences: – Abb. Vie, BMS, Gilead, Janssen, MSD, Vii. V Stefan Esser, Marina Arendt, Robert Jablonka, Christina Schulze, Volker Holzendorf, Norbert H. Brockmeyer, Karl-Heinz Jöckel, Raimund Erbel 2, Nico Reinsch on behalf of HIV HEART Study Group and Heinz Nixdorf Recall Investigative Group

#MOPDB 0101 #IAS 2017 | @IAS_conference More and earlier cardiovascular events (CVE) and shorter overall survival (OS) in HIV-positive patients (HIV+) compared to the general population differ by sex Background • The OS of HIV+ should be adapted to the general population by antiretroviral treatment. • But in the aging HIV+ CVE and strokes became more frequent. Methods • We compare CVE, stroke and OS of HIV+ outpatients of the HIV HEART study (HIVH) and of HIV-negative controls of the population-based Heinz Nixdorf Recall study (HNR), both recruited from the German Ruhr area • HIVH cases with HNR controls are matched in a 1: 2 ratio by sex and age. • CVE are defined by myocardial infarction and sudden cardiac death. Stroke is defined as both ischemic and haemorrhagic stroke. • Cox proportional hazard models are used to investigate the impact of study affiliation on OS, CVE and stroke with time from study start to event or last contact. • In Kaplan Meier curves we display the OS survival and the disease-free survival regarding CVE stratified by HIV status and sex, respectively. Stefan Esser, Marina Arendt, Robert Jablonka, Christina Schulze, Volker Holzendorf, Norbert H. Brockmeyer, Karl-Heinz Jöckel, Raimund Erbel 2, Nico Reinsch on behalf of HIV HEART Study Group and Heinz Nixdorf Recall Investigative Group

#MOPDB 0101 #IAS 2017 | @IAS_conference More and earlier cardiovascular events (CVE) and shorter overall survival (OS) in HIV-positive patients (HIV+) compared to the general population differ by sex Results. HNR: Heinz Nixdorf Recall Study = HNR = General population; HIV HEART Study = HIVH = HIV+ patients • • Model 0 is the crude model showing the HR for being HIV+ compared to be HIV-. Model 1 is adjusted for age, active smoking and for men additionally for diabetes. Stefan Esser, Marina Arendt, Robert Jablonka, Christina Schulze, Volker Holzendorf, Norbert H. Brockmeyer, Karl-Heinz Jöckel, Raimund Erbel 2, Nico Reinsch on behalf of HIV HEART Study Group and Heinz Nixdorf Recall Investigative Group

#MOPDB 0101 #IAS 2017 | @IAS_conference More and earlier cardiovascular events (CVE) and shorter overall survival (OS) in HIV-positive patients (HIV+) compared to the general population differ by sex Results & Conclusions Mean Follow-up time HNR: 7. 6 y, HIVH 4. 8 y OS • • CVE HIV+ males had increased incidence of CVE. HIV+ males had a higher mortality rate and get CVE at younger age than general population. Stefan Esser, Marina Arendt, Robert Jablonka, Christina Schulze, Volker Holzendorf, Norbert H. Brockmeyer, Karl-Heinz Jöckel, Raimund Erbel 2, Nico Reinsch on behalf of HIV HEART Study Group and Heinz Nixdorf Recall Investigative Group