i GEM and The Registry Synthetic Biology Genopole

i. GEM and The Registry Synthetic Biology Genopole Randy Rettberg, Dec. 16, 2010

i. GEM Schedule: Assemble Your Team 5 5 3 3 High School Students Undergraduate Students Graduate Students Faculty Utah State - i. GEM 2009

i. GEM Schedule: Raise Money

i. GEM Schedule: Attend A Workshop

i. GEM Schedule: Get the Bio. Brick Parts

i. GEM Schedule: Work At Your School

i. GEM Schedule: Attend the Jamboree

i. GEM Schedule: Attend the Jamboree

i. GEM Schedule: Win Awards

Medical Applications UC BERKELEY Researchers Arthur Yu • Austin Day • David Tulga • Hannah Cole • Kristin Doan • Kristin Fuller • Nhu Nguyen • Samantha Liang • Vaibhavi Umesh • Vincent Parker Teaching Assistants Amin Hajimorad • Farnaz Nowroozi • Rickey Bonds Creating a Red UC Berkeley i. GEM 2007 Advisors John Dueber • Christopher Blood Cell Substitute Anderson • Adam Arkin • Jay

Save the World - Arsenic Detector A test tube could contain all the necessary components: Freeze dried bacteria, growth medium, indicator powder, Ampicillin salt, etc… • These tubes could then be given to local villagers to monitor their own water quality themselves • A good alternative to the widely used Gutzeit method www. Macteria. co. uk

Live Forever - Bio. Beer - Resveratrol

2009 Winner - Cambridge

Is i. GEM Safe?

Is i. GEM Secure?

i. GEM Sites

Europe Almost Always Wins 2010 2009 2008 2007 2006 Slovenia Cambridge Slovenia Peking Slovenia BCCS-Bristol Freiburg Caltech UC Berkeley Imperial Cambridge Groningen NYMU Taipei Slovenia Princeton Imperial Heidelberg Freiburg Paris Peking Imperial Harvard UC San Francisco TUDelft Valencia UC Berkeley USTC China

Community Parts Collection

Registry DNA Distribution

i. GEM Philosophy Get and Give Teams are expected to use the parts, ideas, and experience of teams in previous years. Teams are expected to contribute their parts, ideas, and experiences.

Community Beyond i. GEM

i. GEM Statistics • • • 7, 362 2, 975 1, 189 118 users have logged in this year have entered parts labs registered 14, 959 part entries in the Registry 7, 172 samples in the Repository 2, 924 parts reported to work 1, 837 samples sent by i. GEM 2010 teams 800 confirmed DNA (of 1000) in 2010 distribution

i. GEM Growth and Scale Year IAP 4 20 2004 5 70 2005 13 130 2006 32 320 2007 54 540 2008 84 840 2009 112 1, 120 2010 130 1, 300 2011 165 1, 650 2012 205 2, 050 2013 04 05 06 07 08 09 10 11 12 13 14 15 Teams Attendance 2014 2015 250 Projected 2, 500 25% Growth 320 3, 200 4, 000

Regional Structure 2011 World Championship Jamboree 30 Judges Americas Jamboree Asian Jamboree European Jamboree 32 Judges 30 Judges

The TTL Data Book

The Registry of Standard Biological Parts

Web of Registries i. GEM Headquarters Genopole Syn. BERC Peking SB Corp Imperial

What we want Viewer Tool Viewer Tool Syn-Bio-Co 1 Syn-Bio-Co 2 Public Data School 1 Lab 1 How can the interfaces be developed?

XML Part Output

Ajax-Based Editing

Device – A ‘Black Box’

Synthetic Biology Question Can simple biological systems be built from standard, interchangeable parts and operated in living cells? Or, is biology so complex that each case is unique?

Synthetic Biology Question Can simple biological systems be built from standard, interchangeable parts and operated in living cells? Sometimes ! Or, is biology so complex that each case is unique? Not always!

i. GEM and The Registry Questions?

Engineering Products – Apple Quadra 840 AV “Ahead of its time, the 840 AV and its relative, the Centris/Quadra 660 AV, were the first Macintoshes to include 16 -bit 48 KHz stereo audio recording capability, as well as S-Video and Composite video input and output. They were also the first personal computers that supported speech recognition (Plain. Talk) out-of -the-box. ”