HYPOXIA RESPIRATORY FAILURE M Tatar Dept of Pathophysiology

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HYPOXIA RESPIRATORY FAILURE M. Tatar Dept. of Pathophysiology

HYPOXIA RESPIRATORY FAILURE M. Tatar Dept. of Pathophysiology

HYPOXIA hypoxemia anoxia ischemia

HYPOXIA hypoxemia anoxia ischemia

glucose 38 ATP Krebs´s cycle O 2 CO 2 H 2 O glucose 2

glucose 38 ATP Krebs´s cycle O 2 CO 2 H 2 O glucose 2 ATP lactate pyruvate

The aim of oxygen transport to preserve high PO 2 gradient between capillaries and

The aim of oxygen transport to preserve high PO 2 gradient between capillaries and mitochondria microcirculation Hb afinity to O 2 respiration erythropoiesis circulation Q x Hb conc. x (Sa. O 2 – Sv. O 2) O 2 c ADP m V O 2

Classification of hypoxia (1) 1. Hypotonic hypoxemic hypoxia - Pa. O 2, Ca. O

Classification of hypoxia (1) 1. Hypotonic hypoxemic hypoxia - Pa. O 2, Ca. O 2; Q. Hb. ( Sa. O 2 – Sv. O 2) - carotid body stimulation, hyperventilation - pulmonary hypertension in chronic form - respiratory failure 2. Izotonic hypoxemic hypoxia - normal Pa. O 2, Ca. O 2; Q. Hb. ( Sa. O 2 – Sv. O 2) - chemoreceptors are not stimulated, lack of dyspnea - anemia, carboxyhemoglobin

Hb concentration and Ca. O 2 interrelationship 300 100 polycythemia Hb = 20 100

Hb concentration and Ca. O 2 interrelationship 300 100 polycythemia Hb = 20 100 normal Hb = 15 150 anemia Hb = 10 20 60 Pa. O 2 , mm. Hg 100 120 100 Sa. O 2, % Ca. O 2, ml/l 200

Classification of hypoxia (2) 3. Hypoextractive hypoxia - increased Hb afinity to O 2

Classification of hypoxia (2) 3. Hypoextractive hypoxia - increased Hb afinity to O 2 - Q. Hb. (Sa. O 2 – Sv. O 2) released O 2 Sa. O 2, % 100 50 p. H = 7, 4; t = 37 °C p. H 7, 4; t 37 °C 6 Pa. O 2, k. Pa 14

Classification of hypoxia 3 4. Hypocirculatory hypoxia - Q. Hb. (Sa. O 2 –

Classification of hypoxia 3 4. Hypocirculatory hypoxia - Q. Hb. (Sa. O 2 – Sv. O 2) - ischemic, congestive; local, general 5. Overutilization hypoxia - demand of tissues for O 2 excesses the available supply - angina pectoris, epilepsy (fatigue and cerebral depression) 6. Histotoxic hypoxia - disturbed ATP production, blocked oxidative phosphorylation - Q. Hb. (Sa. O 2 – Sv. O 2) - cyanide

Respiratory failure - definition Syndrome characterized by disturbed exchange of oxygen and carbon dioxide

Respiratory failure - definition Syndrome characterized by disturbed exchange of oxygen and carbon dioxide in lung Consequences: Pa. O 2 60 mm. Hg (8. 0 k. Pa) with or without Pa. CO 2 > 50 mm. Hg (6. 7 k. Pa) - under resting condition - breathing atmospheric air at sea level Classification: Classification 1. Hypoxemic (hypoxemia with normal or Pa. CO 2) 2. Hypercapnic (hypoxemia and hypercapnia)

Respiratory failure Factors determining oxygenation and ventilation are different Pa. CO 2 must be

Respiratory failure Factors determining oxygenation and ventilation are different Pa. CO 2 must be regarded as a function of the overall ventilation of the entire lung, without regard to local inequalities of distribution of ventilation and perfusion Pa. O 2, on the other hand, depends not only on the amount of alveolar ventilation but also on the matching of ventilation and perfusion

Respiratory failure Mechanisms responsible for gas exchange disturbances A. intrinsic lung disorders (airways, lung

Respiratory failure Mechanisms responsible for gas exchange disturbances A. intrinsic lung disorders (airways, lung parenchyma) 1. Ventilation/perfusion (V´/Q´) mismatch 2. Venous admixture 3. Diffusion impairment B. extrinsic lung disorders (respiratory centre, nerve pathways, respiratory muscles, thoracic cage, pleural space) 1. Alveolar hypoventilation (overall)

ventilatory drive Pa. O 2 Pa. CO 2 100 120 40 30 50

ventilatory drive Pa. O 2 Pa. CO 2 100 120 40 30 50 50 70% Sa. O 2 100% hypoxemia hypercapnia normocapnia chemoreceptors

Respiratory failure Mechanisms of hypoxemia 1. alveolar hypoventilation 2. compartments with low V´/Q´ ratio

Respiratory failure Mechanisms of hypoxemia 1. alveolar hypoventilation 2. compartments with low V´/Q´ ratio 3. right-to-left shunting of blood in compartments with zero V´/Q´ratio 4. diffusion impairment due to thickening of the alveolar-capillary membrane

Diffusion impairment – oxygen saturation of arterial blood normal Pc. O 2 12 k.

Diffusion impairment – oxygen saturation of arterial blood normal Pc. O 2 12 k. Pa impaired exercise rest Pv. O 2 4 0. 8 s Er contact time with A-c membrane

Respiratory failure Mechanisms enhancing hypoxemia Pure oxygen breathing: hypoxic pulmonary vasoconstriction resorptive atelectasis (

Respiratory failure Mechanisms enhancing hypoxemia Pure oxygen breathing: hypoxic pulmonary vasoconstriction resorptive atelectasis ( PAN 2, resorption of O 2) central inspiratory drive

Respiratory failure Mechanisms of hypercapnia 1. overall alveolar hypoventilation 2. critical amount of the

Respiratory failure Mechanisms of hypercapnia 1. overall alveolar hypoventilation 2. critical amount of the compartments with low V´/Q´ ratio overall ventilation must increase to maintain effective alveolar ventilation (normal CO 2 exchange) limits of effective alveolar ventilation: work of breathing respiratory muscle fatigue dead space ventilation

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