Hypothesis Testing OneSample Inference criticalvalue method test statistic

Hypothesis Testing: One-Sample Inference

critical-value method test statistic critical value

Questions: How to estimate a relatively true expression value for each gene? How to identify significantly differential expressed genes across samples? Difficulties: How to reduce type-I error? How to control gene expression over-dispersion? How to deal with low/0 number of replicates?

Home Work/Due Mon. 11. 6, paper Suppose we want to test the hypothesis that mothers with low socioeconomic status (SES) deliver babies whose birthweights are lower than “normal. ” To test this hypothesis, a list is obtained of birthweights from 100 consecutive, full-term, live-born deliveries from the maternity ward of a hospital in a low-SES area. The mean birthweight (x) is found to be 115 oz with a sample standard deviation (s) of 24 oz. Suppose we know from nationwide surveys based on millions of deliveries that the mean birthweight in the United States is 120 oz. 1. Can we actually say the underlying mean birthweight from this hospital is lower than the national average? 2. Suppose the mean birthweight was 119 oz, based on a sample of size 10, 000. Assess the results of the study. 3. Suppose the mean birthweight was 110 oz, based on a sample size of 10. Assess the results of the study.