Hypersensitivity reactions to asparaginase in mice are mediated

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Hypersensitivity reactions to asparaginase in mice are mediated by anti-asparaginase Ig. E and Ig.

Hypersensitivity reactions to asparaginase in mice are mediated by anti-asparaginase Ig. E and Ig. G and the immunoglobulin receptors FcεRI and FcγRIII by Sanjay Rathod, Manda Ramsey, Mary V. Relling, Fred D. Finkelman, and Christian A. Fernandez haematol Volume 104(2): 319 -329 January 31, 2019 © 2019 by Ferrata Storti Foundation

ASNase is recognized ex vivo by B cells, neutrophils, macrophages/monocytes, and basophils after sensitization.

ASNase is recognized ex vivo by B cells, neutrophils, macrophages/monocytes, and basophils after sensitization. Sanjay Rathod et al. Haematologica 2019; 104: 319 -329 © 2019 by Ferrata Storti Foundation

Ex vivo ASNase binding to basophils is dependent on FcγRIII and FcεRI. Sanjay Rathod

Ex vivo ASNase binding to basophils is dependent on FcγRIII and FcεRI. Sanjay Rathod et al. Haematologica 2019; 104: 319 -329 © 2019 by Ferrata Storti Foundation

Frequencies of CD 4+ Tregs, B cells, and basophils increase in blood after ASNase

Frequencies of CD 4+ Tregs, B cells, and basophils increase in blood after ASNase sensitization. Sanjay Rathod et al. Haematologica 2019; 104: 319 -329 © 2019 by Ferrata Storti Foundation

ASNase-sensitized mice develop hypersensitivity reactions when challenged. Sanjay Rathod et al. Haematologica 2019; 104:

ASNase-sensitized mice develop hypersensitivity reactions when challenged. Sanjay Rathod et al. Haematologica 2019; 104: 319 -329 © 2019 by Ferrata Storti Foundation

The in vivo depletion of CD 4+ T cells but not B cells prevents

The in vivo depletion of CD 4+ T cells but not B cells prevents ASNase-mediated hypersensitivity reactions. Sanjay Rathod et al. Haematologica 2019; 104: 319 -329 © 2019 by Ferrata Storti Foundation

Ex vivo ASNase activates basophils in an Ig. G- and Ig. E-dependent manner. Sanjay

Ex vivo ASNase activates basophils in an Ig. G- and Ig. E-dependent manner. Sanjay Rathod et al. Haematologica 2019; 104: 319 -329 © 2019 by Ferrata Storti Foundation

FcεRI and FcγRIII play a role in ASNase hypersensitivity. Sanjay Rathod et al. Haematologica

FcεRI and FcγRIII play a role in ASNase hypersensitivity. Sanjay Rathod et al. Haematologica 2019; 104: 319 -329 © 2019 by Ferrata Storti Foundation

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