Hyperpolarized MRI Imaging By Bilal Badr Outline Hyperpolarization

Hyperpolarized MRI Imaging By Bilal Badr

Outline Hyperpolarization n 13 Carbon Polarization n Method n Results n Discussion n Conclusion n www. coreorthopeadic. com

Hyperpolarization n n Offer unique advantage in improving SNR Goal of Hyperpolarization is to increase nuclear spin alignment Uses inert gases ( 129 Xe , 3 He) or 13 Carbon Utilize low-γ for longer T 1 relaxation Correspond to signal enhancement ~ 10, 000 Eduard Chekmenev et. al. Development of Contrast Agents

1 H n n n Magnetic Resonance Spectroscopy Typically proton used Has been found to be useful in observing metabolites in vivo Disadvantage: Most of signal observed comes from water and fat which masks signals from more interesting metabolites.

13 Carbon n Hyperpolarization Only 1. 1% of carbons in metabolites are 13 C –nuclei Enrich specific molecule with 13 C Applications include: n Angiography n Cellular metabolism www. dpag. ox. ac. uk/research/damian_tyler

13 Carbon Hyperpolarization Jan Henrik et. al. Method for making Hyperpolarized nuclear spins

13 Carbon Hyperpolarization Jan Henrik et. al. Method for making Hyperpolarized nuclear spins

13 Carbon Hyperpolarization Motivation n n Studied effects of Prohance Contains Gadolinium Shortens T 1 of electron in radical and 13 C Increases the amount of polarization Increases time to reach maximum polarization www. ennislaw. com/gadolinium. html

Objective Ideal result where polarization time reduced as much as possible and T 1 is as maximum as possible

Methods Pyruvic Acid + OX 63 Add Prohance Hyperpolarizer B 0 = 3. 35 T T = 1. 4 K Measure T 1 Relaxation Jan Henrik et. al. Method for making Hyperpolarized nuclear spins

Results

Results T 1 (seconds) 95 90 85 T 1 (Seconds) 80 75 70 65 60 55 50 0 0. 5 1 1. 5 2 Pro. Hance Concentration (m. M) 2. 5 3 3. 5

Results Pro. Hance Concentration Vs Polarisation Time Constant 1500 Polarisation Time Constant (Seconds) 1400 1300 1200 1100 1000 900 800 700 600 0 0. 5 1 1. 5 2 Pro. Hance Concentration (m. M) 2. 5 3 3. 5

Results Pro. Hance Concentration Vs t=0 Signal Intensity 3900 t=0 Signal Intensity (Arbitrary Units) 3700 3500 3300 3100 2900 2700 2500 0 0. 5 1 1. 5 2 Pro. Hance Concentration (m. M) 2. 5 3 3. 5

Discussion T 1 (seconds) 95 90 85 80 75 70 65 60 55 50 0 0. 5 1 1. 5 Pro. Hance Concentration Vs Polarisation Time Constant 1500 2 2. 5 3. 5 Pro. Hance Concentration Vs t=0 Signal Intensity 3900 1400 3 3700 1300 3500 1200 1100 3300 1000 3100 900 2900 800 2700 2500 600 0 0. 5 1 1. 5 2 2. 5 3 3. 5

Conclusion In general, the best balance for reducing polarization time and maintaining good T 1 signal is 1. 0 m. M of Prohance

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