Hygiene Preservation Microbial Control Hygiene Preservation Overview Keeping

Hygiene & Preservation

Microbial Control Hygiene & Preservation Overview Keeping Our World Healthy™ Lonza’s hygiene and preservation solutions are designed to support health and well-being. They are used to disinfect and sanitize schools, food processing plants, restaurants, grocery stores, hospitals, homes and more.

Microbial Control Hygiene & Preservation Solutions Internationally approved and registered portfolio Faster path to market Broad formulating options Cost effective solutions Strong regulatory support Microbiological and analytical expertise

Microbial Control Hygiene & Preservation Brands Aldo® Defoamers Amphoterge® Surfactants Bardac® Biocides Bardap® Biocides Barlox® Surfactants Barquat® Biocides Carboquat® Biocides Cosmocil® Antimicrobials Dantogard® Preservatives Dantoserve® Preservatives FMB® Surfactant and Biocide Glycacil® Preservatives Hyamine® Biocides Isocil® Preservatives Lonzabac® Biocides Lonzagard® Disinfectants Lonzaserve® Preservatives Omacide® Fungicides Proxel® Preservatives Sodium Omadine® Fungicide Spectradyne® Biocide Uniquat® Surfactant Vantocil® Antimicrobials Zinc Omadine® Antimicrobials

Microbial Control Hygiene & Preservation Solutions Eight Targeted End Use Areas (1) Healthcare Hospitals and Clinics Extended care facilities Pharmaceutical product ingredients Food Safety Processing plants Retail stores Storage areas Food service Transportation Household/Consumer Kitchen surfaces, Bathroom fixtures Recreational equipment Animal Care Veterinary services Animal science Kennels Pet shops

Microbial Control Hygiene & Preservation Solutions Eight Targeted End Use Areas (2) Agriculture Animal premises Transportation Professional Services Dental offices Medical / doctor offices Tanning salons Beauty salons and barber shops Health spa Institutional/Commercial Transportation services Educational facilities Office buildings Hospitality Contract maintenance services Industrial Manufacturing facilities Pharmaceutical manufacturing companies

Microbial Control Antimicrobial Active - Bardac™ 22, 2240, 2270 E, 2280 i § § § § Broad spectrum of activity against both gram positive and gram negative bacteria. Fungicide and mildewcide. Active against enveloped viruses (e. g. Hepatitis B, HIV). High tolerance to hard water. Maintains efficacy in presence of heavy organic soiling such as blood and protein. Good surfactant and wetting properties. Worldwide acceptance based on registrations approval and official lists. Toxicological and ecological documentation. N, N-Didecyl-N, N-dimethylammoniumchloride 7

Microbial Control Antimicrobial active - Barquat™ DM-50, DM-50 -EP, DM-80 § Specially selected blends of Alkyl Dimethyl Benzyl Ammonium Chlorides. § Effective microbicide, deodorant and algaecide. § Ph. Eur. compliance for DM-50 -EP Alkyl Dimethyl Benzyl Ammonium Chloride 8

Microbial Control Antimicrobial active - Barquat™ MB-50, MB-80 § Specially selected blends of Alkyl Dimethyl Benzyl Ammonium Chlorides § High germicidal activity in hard water § Effective microbicide, deodorant and algaecide N-Alkyl-N, N-dimethyl-N-benzylammonium Chloride INN: Benzalkoniumchloride 9

Microbial Control Antimicrobial active - Barquat™ CB-50 § Blend of Alkyl Dimethyl Benzyl Ammonium chlorides. § Effective Microbicide, Fungicide, Deodorant, Algaecide N-Alkyl-N, N-dimethyl-N-benzylammonium Chloride

Microbial Control Antimicrobial active - Barquat™ MS-100 § § Powder product Excellent hard water tolerance for sanitizing Excellent hard surface disinfection Excellent hard water solubility N-Alkyl-N, N-dimethyl-N-benzylammonium Chloride

Microbial Control Antimicrobial active - Barquat™ LB-50 § § Lower foaming capacity Effective bactericide for milk industry and beverage industry. Effective slimicide for cooling towers. Effective algaecide for swimming pools. Alkyl Dimethyl Benzyl Ammonium Chloride INN: Benzalkoniumchloride 12

Microbial Control Antimicrobial active - Bardac™ LF, LF-70 § Lowest tendency to foam. § Broad spectrum of biocidal activity against both gram positive and gram negative organisms. § Algaecidal performance N, N-Dioctyl-N, N-dimethylammoniumchloride

Microbial Control Antimicrobial active - Bardac™ 2170 P § § Lower foaming Broad spectrum activity against both gram positive and gram negative bacteria Superior fungicide Excellent algaecide N-Decyl-N-isononyl-N, N-dimethylammoniumchloride

Microbial Control Antimicrobial active - Bardap™ 26 § § § Chloride-free Broad spectrum activity against both gram positive and gram negative bacteria Exceptional fungicide and mildewcide High tolerance to hard water Low corrosive Maintains efficacy in presence of heavy organic soiling such as blood and protein N, N-Didecyl-N-methyl-poly(oxyethyl) ammonium propionate

Microbial Control Antimicrobial blend - Bardac™ 114 § § § Specially selected blends of Dialkyl-Quats and Benzalkonium-Quats Broad spectrum activity against both gram positive and gram negative organisms Exceptional fungicide and mildewcide Moderate irritant Good surfactant and wetting properties Blend of… N-Alkyl(C 12 -16)-N-benzyl-N, N-dimethylammoniumchloride Didecyl dimethylammoniumchloride N-Alkyl(C 12 -14)-N-ethylbenzyl-N, N-dimethylammoniumchloride 16

Microbial Control Antimicrobial blend - Bardac™ 205 -Mi, 208 -Mi § Excellent disinfectant performance § Broad spectrum of biocidal activity against both gram positive and gram negative organisms. § Favourable hard water tolerance for sanitizing activity § Exceptional fungicidal performance § Valuable organic soil tolerance § Toxicological and ecological documentation Blend of… N-Alkyl-N, N-dimethyl-N-benzylammonium chloride Octyl decyl dimethyl ammonium chloride

Microbial Control Antimicrobial blend - Barquat™ 4250 -Z, 4280 -Z § Excellent disinfectant performance § Broad spectrum of biocidal activity against both gram positive and gram negative organisms. § Active against viruses, fungi and algae. § Valuable organic soil tolerance Blend of… Alkyl (C 14 60%, C 16 30%, C 12 5%, C 18 5%) Dimethyl Benzyl Ammonium Chloride Alkyl (C 12 68%, C 14 32%) Dimethyl Ethylbenzyl Ammonium Chloride

Microbial Control Antimicrobial active - Lonzabac™ 12. 30, 12. 100 § § § § Broad spectrum activity against gram positive and gram negative bacteria Activity against TB Maintains high efficacy also in presence of heavy organic soiling, such as blood and protein Active against enveloped viruses (e. g. Hepatitis-B) Good surfactant properties Compatible with selected anionic surfactants Toxicological and ecological documentation Bis-(3 -aminopropyl) dodecylamine

Microbial Control Antimicrobial active – Spectradyne™ § § § Broad spectrum bactericide and virucide Stable and effective over wide p. H range Low foam Established antimicrobial in fields of animal and human hygiene GMP- and DMF-compliant grade available 20

Microbial Control Lonzagard™ Benzethonium Chloride USP § § Quality standard meets with USP Especially suited formulating dry powdered products High germicidal activity in hard water Widely acceptable worldwide as a fast-acting preservative and as an active antimicrobial ingredient 21

Microbial Control Antimicrobial active – Vantocil™ IB, TG, 100 § § § § Broad spectrum bactericide and virucide Retains activity in hard water and various types of soil Stable and effective over wide p. H range 1 -11 Non-foaming Does not leave perceivable residues on treated surfaces No development of organism tolerance and resistance Low odour, VOC-free and AOX-free Available in powder form – soluble to over 50% Poly (hexamethylenebiguanide) hydrochloride 22

Microbial Control Antimicrobial active – Cosmocil™ PG § § Established - and growing – use within skin and wound care Active against antibiotic-resistance bacteria Agent of choice for poorly-healing chronic wounds Supported by ASMF and ICH Q 7 manufacture Polyhexanide Poly (hexamethylenebiguanide) hydrochloride 23

Microbial Control Antimicrobial active – Lonzabac™ MP § § § Wide spectrum of activity Effective against bacteria, fungi, yeast, spores, viruses Inactivates Polio virus Safe at use concentrations Mild oxidizer 24

Microbial Control Lonzagard™ and Vantocil™ Surface Disinfectants and Disinfectant Cleaners Veterinary Lonzagard DM 114 -10 Lonzagard DR-19 a. B Lonzagard DR-25 a. N Lonzagard DR-LS-13 N Lonzagard DR 15 Lonzagard MC -A-30 Vantocil FHC Healthcare Processing plants (e. g. food, pharma) Commercial and institutional

Microbial Control Lonzagard™ DR-25 a. N Customer benefits Use areas Main use in hospitals, veterinary and dental surgeries Basic chemistry Cleaning and disinfection in one step Aldehyde free Effective against C. difficile spores with full virucidal spectrum of activity Based on didecyl dimethyl ammonium chloride (DDAC) Efficacy Bactericidal (incl. MRSA) Fungicidal and Yeasticidal (incl. Aspergillus niger) Sporicidal (against Clostridium difficile and B. cereus) Virucidal (against both enveloped and non-enveloped viruses incl. Polio, Adeno, Noro, HIV, Hep B, Rota, BVDV, ECBO and Influenza)

Microbial Control Lonzagard™ DR-LS-13 N Customer benefits Use areas Main use in restaurants and food processing plants as well as institutional environments (schools, office buildings, athletic facilities and veterinary clinics) Basic chemistry Cleaning and disinfection in one step Excellent cleaning performance Free of aldehyde and quaternary ammonium compounds Tuberculocidal efficacy Based on Bis (3 -aminopropyl)-N-dodecylpropane-1, 3 -diamine (Lonzabac™ 12) Efficacy Bactericidal (incl. Salmonella) Yeasticidal Tuberculocidal according VAH requirements (M. tuberculosis) Virucidal (against enveloped viruses incl. Vaccinia, BVDV and Influenza)

Microbial Control Lonzagard™ DM-114 -10 Customer benefits Use areas Main use areas include institutional environments (schools, office buildings, solarium, long term care institutes, sun beds & fitness facilities) Basic chemistry Disinfection in a convenient concentrated formula Non corrosive labeling of the formulation Excellent compatibility with acrylic glass Approved bactericidal efficacy in 1 minute Based on blend of quaternary ammonium compounds Efficacy Bactericidal Yeasticidal Virucidal (against both enveloped and non-enveloped viruses including HBV, HIV, Rota, Noro and Vaccinia)

Microbial Control Lonzagard™ DR-19 a. B Customer benefits Use areas Main use in commercial and institutional settings (including restaurants, schools, sport & leisure facilities etc. ) Basic chemistry Clean and disinfect in a single step Based on Didecyl dimethyl ammonium chloride (DDAC) Efficacy Bactericidal (incl. Salmonella, MRSA) Yeasticidal Virucidal (against enveloped viruses incl. Hepatitis B and influenza)

Microbial Control Lonzagard™ DR-15 Customer benefits Use areas Main use in hospitals, long term care facilities, veterinary clinics Actives Cleaning and disinfection in one step Outstanding ‘non-sticky effect suitable for floor applications Aldehyde free Tuberculocidal efficacy Based on Didecyl dimethyl ammonium chloride (DDAC) and Bis (3 -aminopropyl)N-dodecylpropane-1, 3 -diamine (Lonzabac™ 12) Efficacy Bactericidal and yeasticidal (incl. MRSA) Tuberculocidal (M. tuberculosis) Virucidal (against enveloped viruses incl. Noro, HBV, Papova and Influenza)

Microbial Control Lonzagard™ MC-A-30 Customer benefits Use areas Main use area for veterinary applications Actives Broad spectrum efficacy Cleaning and disinfection in one step Acidic p. H Based on Didecyl dimethyl ammonium chloride (DDAC) and Glutaraldehyde Efficacy Bactericidal (incl. Salmonella) Fungicidal Virucidal (incl. foot & mouth disease, canine hepatitis virus, classical swine fever [Togo virus], Aphto virus [Picorna])

Microbial Control Vantocil™ FHC Customer benefits Use areas Main use in Hospitals, poultry & livestock, industrial and institutional applications Actives Cleaning and disinfection in one step Good material compatibility Effective in the presence of high organic load Based on poly(hexamethylene)biguanide hydrochloride (PHMB) and benzalkonium chloride (BAC) Efficacy Bactericidal (incl. MRSA) Yeasticidal Virucidal (incl. Hepatitis C, HIV, Rota, Swine Flu, )

Microbial Control Lonzagard™ ID-50 Customer benefits Use areas Hospitals, dentists and veterinary clinics Basic chemistry One step instrument disinfectant and cleaner for surgical instruments in hospitals and in dental applications before sterilization. Cost effective formula without any aldehydes Good material compatibility Based on N, N-Didecyl-N-methyl-poly(oxyethyl) ammonium propionate (Bardap™ 26) and Bis (3 -aminopropyl)-N-dodecylpropane-1, 3 -diamine (Lonzabac™ 12) Efficacy Bactericidal Tuberculocidal according to VAH requirements (M. tuberculosis) Virucidal (against enveloped viruses, incl. HBV, HIV, Vaccinia, BVDV)

Microbial Control Lonzagard™ HD-2 Customer benefits Use areas Main use in hospitals, long term care facilities, dentists and veterinary clinics, restaurants, food processing plants and institutional facilities Basic chemistry Ready to use hygienic hand wash Based on Didecyl dimethyl ammonium chloride (DDAC) and 1 -propanol Efficacy Bactericidal (according to EN 1499) Virucidal (against Hepatitis B, Influenza)