Homework 3 is due 411 Bonus 2 is
Homework #3 is due 4/11. Bonus #2 is due W 4/4. Bonus #3 is due F 4/27. E. coli Phage virus Fungus from soil Ebola
The Immune System • Non-specific: – barriers • Specific: – B-cells -> antibodies – T-cells CB 43. 2
Non-Specific Immune System Barriers: Skin. Dry Inhospitable Competition Secretions (lysozyme) Hairs and Mucus (protect openings) Traps particles, swallowed Stomach acid kills pathogens CB 43. 2
Skin protects us from most pathogens CB 43. 2
Non-Specific Immune System Barriers: Skin. Dry Inhospitable Competition Secretions (lysozyme) Hairs and Mucus (protect openings) Traps particles, swallowed Stomach acid kills pathogens CB 43. 2
esophagus stomach
Non-Specific Immune System Barriers: Skin. Dry Inhospitable Competition Secretions (lysozyme) Hairs and Mucus (protect openings) Traps particles, swallowed Stomach acid kills pathogens CB 43. 2
The Immune System • Non-specific: – barriers • Specific: – B-cells -> antibodies – T-cells CB 43. 2
The Specific Immune System
B-cells and T-cells move through the circulatory system scanning for pathogens
B-cells develop in bone marrow T-cells in the thymus CB 43. 10
B-cells make and secrete antibodies CB 43. 12
Variable region An Antibody Constant region CB 43. 8
Antibodies recognize and bind to antigens CB 43. 7
B-cells male antibodies that bind to antigens marking them for destruction CB 43. 12 and 19 Marked for destruction by WBC
What about damaged or abnormal cells? • Viral infections • Cancer cells • Non-functional cells
T-cells recognize and destroy abnormal cells CB 43. 16
Immune System Overview CB 43. 14
It can take 7 -14 days to produce sufficient antibodies to eliminate a pathogen CB 43. 13
Memory B-cells make the response to a second exposure more rapid This is how vaccines work. CB 43. 17 Marked for destruction by WBC
Vaccines work via memory B-cells that make the response to a second exposure more rapid CB 43. 13
The immune system during HIV infection
Homework #3 is due 4/11. Bonus #2 is due W 4/4. Bonus #3 is due F 4/27. E. coli Phage virus Fungus from soil Ebola
- Slides: 23