HIVAIDS Implementation Science Research Across NIH Recent Highlights

HIV/AIDS Implementation Science Research Across NIH: Recent Highlights, Current Priorities, and Partners Christopher Gordon, Ph. D Branch Chief, Division of AIDS Research National Institute of Mental Health

Top Line Messages Ø HIV/AIDS implementation science has been supported across NIH since prevention and treatment tools have been available Ø A wide range of dissemination and implementation research has been solicited through FOAs from many ICs. Ø Partnering with implementing agencies (e. g. , CDC, PEPFAR) has been critical, and continues to expand. Ø Moving forward, important to triage and target highest priorities, coordinate efforts, and seek efficiencies

Implementation Research: What is it? 3

The Case for Implementation Research in HIV/AIDS Fauci, A. S. , et al. (2013). Nature immunology, 14(11), 1104 -1107. doi: 10. 1038/ni. 2735 4

National Institutes of Health: HIV Implementation Science Elias Zerhouni, M. D. Director, NIH National. Institute on on. Aging National. Institute on on. Alcohol. Abuse and. Alcoholism National. Institute of of. Allergyand Infectious. Diseases National. Institute of of. Arthritisand Musculoskeletal and and. Skin. Diseases National. Cancer Institute National. Institute of of. Child. Health and. Human Development National. Instituteon on Deafnessand and. Other Communication Disorders National. Institute of of. Dentaland Craniofacial Research National. Institute of of. Diabetesand Digestiveand Kidney. Diseases National. Institute on on. Drug. Abuse National. Institute of of. Environmental Health. Sciences National. Eye Institute National. Institute of of. General Medical. Sciences National. Heart, Lung, and. Blood Institute National. Human Genome. Research Institute National. Institute of of. Mental. Health National. Institute of of. Neurological Disordersand Stroke National. Institute of of. Nursing. Research National. Instituteof of Biomedical. Imaging and. Bioengineering National. Center for. Complementary and. Alternative Medicine Fogarty International Center National. Center for. Research Resources National. Library of of. Medicine National. Centeron on Minority. Healthand Health. Disparities Clinical. Centerfor Information Technology Centerfor Scientific. Review

A (partial) Timeline for NIH-funded HIV/AIDS Implementation Science Ø Early 2000 s, research funded in dissemination and implementation science focused on evidence-based prevention interventions Ø NIMH published a PA in 2006 focused on D&I research in collaboration with the CDC’s DEBI project (Diffusion of Effective Behavioral Intervention) Ø NIMH standing FOA (revised and updated every three years) that has evolved with the availability of further prevention and treatment advances. Ø Trans-NIH Implementation Science Workgroup, led by NCI Ø 2009 OAR and Pangaea Global AIDS Foundation Consultation on Implementation Science at IAS, Capetown. Ø PEPFAR workgroup, led by Melanie Bacon (NIAID), including initiatives in implementation science and most recently, in HOP process Ø NIH/PEPFAR RFAs and PAs, starting in 2011, NIAID-led. Ø NIDA/PEPFAR RFA in 2012 Ø NICHD/PEPFAR RFA in 2012 for PMTCT Implementation Science 6

A (partial) Timeline for NIH-funded HIV/AIDS Implementation Science Ø CFAR, CDC, and Public Health Department collaboration on research efforts to leverage and support the ECHPP efforts (2013 -2016) Ø NIMH/NIAID 2013 priority-setting meeting Ø NIMH 2016 supplements “HIV Pre-exposure Prophylaxis (Pr. EP) Implementation Science in CDC-funded Public Health Demonstration Projects (Admin Supp)” PA-16 -199 Ø NIMH standing FOA revised and published in January 2017: “Targeted Implementation Science to Achieve 90/90/90 Goals for HIV/AIDS Prevention and Treatment (R 01)” Ø NIMH Initiatives with PEPFAR for Pr. EP Implementation Science and Mental Health Screening and Treatment in HIV/AIDS Care Settings 7

Treat All: Policy uptake to full implementation, July 2016 • Implementation of Treat All is just starting. Implementation Science to test models for differentiated care and taskshifting

Ambassador Birx: Closing the implementation gap at the Adherence Conference, May 2016 IAPAC Adherence 2017 June 4 -6, 2017 • Miami http: //www. iapac. org/Adherence. Conference/Adherence_2016. html

NIMH-funded projects at PEPFAR sites • 28 Active Grants Kenya, Uganda, South Africa, Tanzania, Zambia, Botswana, Mozambique • • Understanding mobility and risk in SEARCH communities Agricultural Intervention for Food Security and HIV Health Outcomes Real World Adherence to HIV Pr. EP in Serodiscorant African Couples Activating Treatment as Prevention through Community Mobilization Group Psychotherapy for HIV-Positive Depressed Perinatal Women Patient-Centered Disclosure Intervention for HIV-Infected Children Adaptive Strategies for Preventing & Treating Lapses of Retention in Care CHW's m. Health, and Combination HIV Prevention in a Hotspot

HIV Prevention and Care Continuum, Psychosocial Comorbidities, & Translational Research Branch • Chris Gordon Ph. D. • Greg Greenwood Ph. D. • Mike Stirratt Ph. D. • Teri Senn Ph. D. Branch Chief; HIV Prevention and Treatment Implementation Science Program Adherence to Treatment and Prevention Program HIV Testing and Social Determinants Program Psychosocial Co-morbidities of HIV Prevention and Treatment Program

NIMH Funding Opportunities FOAs outline and describe the high priority areas for the DAR programs

NIMH Division of AIDS Research Contact Information Susannah Allison, Ph. D. allisonsu@mail. nih. gov Pim Brouwers Ph. D. ebrouwer@mail. nih. gov Deborah Colosi, Ph. D. Deborah. colosi@nih. gov Christopher Gordon, Ph. D. cgordon 1@mail. nih. gov Gregory Greenwood, Ph. D. gregory. greenwood@nih. gov Jeymohan Joseph, Ph. D. jjeymoha@mail. nih. gov Vasudev R Rao, MBBS, MS. raovr@nih. gov Dianne Rausch, Ph. D. drausch@mail. nih. gov Teri Senn, Ph. D. teri. senn@nih. gov Michael Stirratt, Ph. D. stirrattm@mail. nih. gov David Stoff, Ph. D. dstoff@mail. nih. gov 5601 Fishers Lane Rockville, MD 20852 THANKS!