HIV1 RNA persists in rectal tissue despite rapid
- Slides: 6
HIV-1 RNA persists in rectal tissue despite rapid virologic suppression in blood plasma with dolutegravir-based combination antiretroviral therapy in treatment naïve patients Cecile D. Lahiri, MD, MS Emory University School of Medicine Department of Medicine Division of Infectious Diseases Nakita Brown, MS; Hsin Chien, Ph. D; Aswani Vunnava, MS; Kevin J. Ryan, MS; Edward P. Acosta, Pharm. D; Anandi S. Sheth, MD, MS; Jessica Ingersoll, MS; Igho Ofotokun, MD, MS #IAS 2017 | @IAS_Conference
#IAS 2017 | @IAS_conference Conflict of Interest No conflicts of interest to declare.
#IAS 2017 | @IAS_conference Background and Methods Background • Despite plasma virologic suppression with c. ART, HIV persists in gut • Tissue HIV viral dynamics and relationships with ART drug concentrations remain poorly understood Methods • Study population: Treatment-naïve HIV+ adults in Atlanta, Georgia USA • Statistical analyses: – Participants grouped: Undetectable rectal HIV RNA (<40 cop/g) vs Detectable RNA – Median DTG concentrations in blood and rectal tissue
#IAS 2017 | @IAS_conference Results: HIV Viral Dynamics • 8 participants enrolled • 30 paired plasma and rectal tissue samples available for HIV RNA analysis Blood plasma Rectal tissue
#IAS 2017 | @IAS_conference Results and Discussion 22 paired plasma and rectal tissue samples for steady state DTG analysis • • 7 samples from participants attaining undetectable rectal HIV RNA 15 samples from participants with persistent detectable rectal HIV RNA Rectal DTG concentrations • HIV RNA persisted in rectal tissue • Those with undetectable rectal HIV RNA had higher median tissue DTG concentrations Implications: ART pharmacometrics plays a role in tissue HIV viral dynamics
#IAS 2017 | @IAS_conference Acknowledgements Emory ID Division Igho Ofotokun, MD, MS Nakita Brown, MS Hsin Chien, Ph. D Aswani Vunnava, MS Anandi Sheth, MD, MS Funding sources K 23 AI 124913 KL 2 TR 000455 and UL 1 TR 000454 Emory CFAR Virology Core Lab Colleen Kraft, MD, MS Jessica Ingersoll, MS UAB Division of Clinical Pharmacology Edward P. Acosta, Pharm. D Kevin Ryan, MS Atlanta WIHS Team Grady Infectious Disease Program Atlanta WIHS: U-01 AI 103408 Emory CFAR: P 30 AI 050409 Emory Medical Care Foundation
