History of the Dan L Duncan Cancer Center

History of the Dan L. Duncan Cancer Center 1997 Strategic plan recommendation 2002 Successful P 20 application 2003 -2005 Programs, shared resources, organizational structure, infrastructure 2006 P 30 CCSG submitted Duncan gift 2007 NCI Cancer Center grant awarded

Mission of the Dan L. Duncan Cancer Center To prevent and ultimately cure cancer in all of its forms • To provide exceptional patient care • To provide outstanding education for students • To conduct innovative research into the causes, prevention and treatment of cancer • To provide community outreach and education, especially to the underserved

Hospital Partnerships and Patient Care Programs Harris County Hospital District

BCM Affiliates & Facilities BCM Clinic Rice Consortium Texas Children’s Hospital St. Luke’s Hospital Alkek Research Tower Baylor College of Medicine Ben Taub General Hospital Michael E. De. Bakey VA Medical Center

The Texas Medical Center RICE UNIVERSITY VAMC Parkwood

Research Programs Cancer Biology Franko De. Mayo, Ph. D Molecular Carcinogenesis Janet Butel, Ph. D Nuclear Receptors Orla Conneely, Ph. D Breast Cancer Dan Medina, Ph. D Cell and Gene Therapy Malcolm Brenner, MD, Ph. D Prostate Cancer Tim Thompson, Ph. D Cancer Prevention Powel Brown, MD, Ph. D Pediatric Cancer David Poplack, MD

Membership and Grant Support Total members NCI Grant Support Total Cancer Funding SPOREs Program Projects U 01 Mouse Models U 54 U 19 LLS SCOR U 01 Redes en Accion 270 ≈$ 40 M ≈$100 M 3 5 4 2 2 1 1

Developing Program Working Groups Gastrointestinal Cancer Pancreas Cancer Lymphoma Melanoma Gene sequencing of human tumors

Shared Resources Genetically Engineered Mouse Integrated Microscopy Franco De. Mayo, Ph. D Mike Mancini, Ph. D Protein Expression/Proteomics Dean Edwards, Ph. D Genomic Profiling …………… Lisa White, Ph. D and Eastwood Leung, Ph. D Biostatistics/Data Management Sue Hilsenbeck, Ph. D Clinical Trials Support Unit Martha Mims, MD, Ph. D Cell Processing/Vector Production Adrian Gee, Ph. D Cytogenetics Core Rizwan Naeem, MD Flow Cytometry Tissue Acquisition/ Pathology Dorothy Lewis, Ph. D Tom Wheeler, MD

Other Baylor Core Facilities • Bioinformatics Research Center • Blot Analysis • DNA Sequencing • Interdepartmental Deconvolution Microscope • Vector Development • Mouse Phenotyping

Clinical Research • 4, 000 new cancer patients diagnosed annually in partner hospitals • 40% minority; 55% female • 90 Investigator-initiated trials • NCI-funded cooperative group membership - SWOG - NSABP - ACOSOG - COG - PBTC - CALGB

Nanoshell Treatment of U 373 Glioma Cells Bare-NS PEG-NS Anti-IL-13 r-NS Live Dead In press, Neuro-Oncology, 2007

Future Plans of the DLDCC in Nanotechnology & Nanomedicine • Continue ongoing collaborations on nanotechnology projects with Rice and UT • High priority for ongoing/future research • Encourage faculty participation in the Keck Center Nanobiology Training program • Encourage trainees to participate in training programs/projects in nanotechnology • Commitment to space in the Rice Consortium building