Hinf IMTHFR 677DNA lane 1 Maker w lane Slides: 20 Download presentation ● Hinf I酶切MTHFR 677基因DNA 片段产物电泳图 lane 1: Maker; w lane 2: C/C genotype; w lane 3: C/T genotype; w lane 4: T/T genotype. w 198 bp 175 bp ▲ Mbo Ⅱ酶切MTHFR A 1298 C基因 DNA片段产物电泳图 lane 1: Maker; w lane 2: Product of PCR; w lane 3: A/A genotype; w lane 4: A/C genotype. w 84 bp 56 bp ● MTHFR基因型和新辅助化疗疗效的关系(表 1) Effects of chemotherapy Genetype C 677 T type n CR+PR(%) SD+PD(%) X 2 T/T C/C 18 29 14 15(83. 3) 21(72. 4) 6(42. 9) 3(16. 7) 8(27. 6) 8(57. 1) 0. 72 5. 54 0. 02 A/A A/C C/C 44 17 0 31(70. 5) 11(64. 7) 0 13(29. 5) 6(35. 3) 0 0. 19 0. 67 P 0. 40 A 1298 C ● MTHFR基因型与乳腺癌新辅助化疗病理反应率 的关系(表 2) reaction rate of chemotherapy Genetype C 677 T type n 0(%) Ⅰ-Ⅲ(%) X 2 T/T C/C 18 29 14 3(16. 7) 10(34. 5) 9(64. 3) 15(83. 3) 19(65. 5) 5(35. 7) 1. 72 7. 38 0. 01 A/A A/C C/C 44 17 0 13(29. 5) 9(52. 9) 0 31(70. 5) 8(47. 1) 0 2. 86 0. 09 P 0. 19 A 1298 C MTHFR 1298 A/C 患者的化疗疗效 insignificant differences MTHFR A 1298 C基因多态 与乳腺癌新辅助化疗敏感性之间 相关性不明显 50. 0<P MTHFR 1298 A/A 患者的化疗疗效 MTHFR 1298 A/C I~III级化疗反应率 MTHFR 1298 A/A I~III级化疗反应率 有文献报道 1298基因多态对细胞内叶酸分布的影响明显低于677基因多态, 故 1298基因多态对化疗敏感性的影响同样低于677基因多态,本研究结果亦然。 [Vander Put NM, Gab reels F, Stevens EM, et al. A second common Mutation in the methylenetetrahydrololate reductase gene: an additional risk factor for neural-tube defects[J]. Am J Hum Genet, 2005, 62(2): 1044 -1051. ] Groups in the windows movie maker ribbonOutside lane vs inside laneGolden ratio poemCloze makerWriter thinker maker textbookSueño picassoCore game engineHpc container makerChart dog intervention centralScalable annotation pipelineTutorial video makerRsform conditional fieldsStart flowchartBohr rutherford diagram for fluorineShooter game makerKfc makerGame maker delayKurva makerCollaborative poster makerSmart note taker technologyAcute angle in real life