Hinf IMTHFR 677DNA lane 1 Maker w lane

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● Hinf I酶切MTHFR 677基因DNA 片段产物电泳图 lane 1: Maker; w lane 2: C/C genotype; w

● Hinf I酶切MTHFR 677基因DNA 片段产物电泳图 lane 1: Maker; w lane 2: C/C genotype; w lane 3: C/T genotype; w lane 4: T/T genotype. w 198 bp 175 bp

▲ Mbo Ⅱ酶切MTHFR A 1298 C基因 DNA片段产物电泳图 lane 1: Maker; w lane 2: Product

▲ Mbo Ⅱ酶切MTHFR A 1298 C基因 DNA片段产物电泳图 lane 1: Maker; w lane 2: Product of PCR; w lane 3: A/A genotype; w lane 4: A/C genotype. w 84 bp 56 bp

● MTHFR基因型和新辅助化疗疗效的关系(表 1) Effects of chemotherapy Genetype C 677 T type n CR+PR(%) SD+PD(%)

● MTHFR基因型和新辅助化疗疗效的关系(表 1) Effects of chemotherapy Genetype C 677 T type n CR+PR(%) SD+PD(%) X 2 T/T C/C 18 29 14 15(83. 3) 21(72. 4) 6(42. 9) 3(16. 7) 8(27. 6) 8(57. 1) 0. 72 5. 54 0. 02 A/A A/C C/C 44 17 0 31(70. 5) 11(64. 7) 0 13(29. 5) 6(35. 3) 0 0. 19 0. 67 P 0. 40 A 1298 C

● MTHFR基因型与乳腺癌新辅助化疗病理反应率 的关系(表 2) reaction rate of chemotherapy Genetype C 677 T type n

● MTHFR基因型与乳腺癌新辅助化疗病理反应率 的关系(表 2) reaction rate of chemotherapy Genetype C 677 T type n 0(%) Ⅰ-Ⅲ(%) X 2 T/T C/C 18 29 14 3(16. 7) 10(34. 5) 9(64. 3) 15(83. 3) 19(65. 5) 5(35. 7) 1. 72 7. 38 0. 01 A/A A/C C/C 44 17 0 13(29. 5) 9(52. 9) 0 31(70. 5) 8(47. 1) 0 2. 86 0. 09 P 0. 19 A 1298 C

MTHFR 1298 A/C 患者的化疗疗效 insignificant differences MTHFR A 1298 C基因多态 与乳腺癌新辅助化疗敏感性之间 相关性不明显 50. 0<P

MTHFR 1298 A/C 患者的化疗疗效 insignificant differences MTHFR A 1298 C基因多态 与乳腺癌新辅助化疗敏感性之间 相关性不明显 50. 0<P MTHFR 1298 A/A 患者的化疗疗效 MTHFR 1298 A/C I~III级化疗反应率 MTHFR 1298 A/A I~III级化疗反应率 有文献报道 1298基因多态对细胞内叶酸分布的影响明显低于677基因多态, 故 1298基因多态对化疗敏感性的影响同样低于677基因多态,本研究结果亦然。 [Vander Put NM, Gab reels F, Stevens EM, et al. A second common Mutation in the methylenetetrahydrololate reductase gene: an additional risk factor for neural-tube defects[J]. Am J Hum Genet, 2005, 62(2): 1044 -1051. ]