Higherorder structure of chromosomes Mateusz Skowron Pawe lusarczyk

Higher-order structure of chromosomes Mateusz Skowron Paweł Ślusarczyk Supervisor: Joanna Deperas-Standyło

Theory Human lymphocyte cell nucleus – filled with 23 pairs of chromosomes containing DNA

Theory Human lymphocyte cell nucleus – filled with 23 pairs of chromosomes containing DNA Chromosomes in phase G 0/G 1 have form of long and screwed strings

Theory Human lymphocyte cell nucleus – filled with 23 pairs of chromosomes containing DNA Chromosomes in phase G 0 / G 1 have form of long and screwed strings Firstly believed to form a chaotic spaghetti-like structure

Theory Human lymphocyte cell nucleus – filled with 23 pairs of chromosomes containing DNA Chromosomes in phase G 0 / G 1 have form of long and screwed strings Firstly believed to form a chaotic spaghetti-like structure 1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories

Theory Human lymphocyte cell nucleus – filled with 23 pairs of chromosomes containing DNA Chromosomes in phase G 0 / G 1 have form of long and screwed strings Firstly believed to form a chaotic spaghetti-like structure 1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories

Theory Human lymphocyte cell nucleus – filled with 23 pairs of chromosomes containing DNA Chromosomes in phase G 0 / G 1 have form of long and screwed strings Firstly believed to form a chaotic spaghetti-like structure 1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories

Theory Human lymphocyte cell nucleus – filled with 23 pairs of chromosomes containing DNA Chromosomes in phase G 0 / G 1 have form of long and screwed strings Firstly believed to form a chaotic spaghetti-like structure 1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories

Nucleus model Nucleus – sphere Chromosomal domain – sphere Domains can overlap each other Chromosomal domains in the nucleus

CHROMOSOME MODEL A real chromosome Model chromosome – a chain of connected spheres Spheres in each chromosome cannot overlap each other Chromosomal territories in the nucleus

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