Herpes Viruses Herpes zoster Chickenpox Shingles Filename Herpes

Herpes Viruses Herpes zoster Chickenpox Shingles Filename Herpes 2. ppt 1 9/25/2021

Herpes Zoster Outline þStructure þClassification þMultiplication þClinical manifestations þEpidemiology þDiagnosis þControl 2 Baron’s Web Site 9/25/2021

Varicellovirus þgenus in herpesvirus family þhuman herpesvirus 3 (HHV 3) þvaricella-zoster virus 3 9/25/2021

Herpes Zoster virus 4 9/25/2021

Chickenpox varicella 5 9/25/2021

Varicella (chickenpox) 6 9/25/2021

Varicella eruption 7 9/25/2021

Varicella eruption 8 9/25/2021

Chickenpox vesicle 9 9/25/2021

Tzanck cell Chickenpox vesicle 10 9/25/2021

Chickenpox þchicken pox is the acute primary disease þshingles is the delayed recurrent form of the same disease þbegins as a disease of childhood þaerosol from a child most common source þvirus enters nose or throat - airborne - very communicable. þearly viral multiplication in upper respiratory 9/25/2021 11 tract, no symptoms; not infectious.

Chickenpox þIncubation 10 -20 days þvirus begins to disseminate during the latter part of the incubation period. þvirus enters regional lymph nodes. Passes into the blood and internal organs. þpatient becomes infectious 3 -4 days before the first pox is seen. Sore throat is common 1 -2 days before the first pox. 12 9/25/2021

Chickenpox þpox appears 14 -21 days after the exposure. Usually, a macular i. e. flat rash appears on the skin. within 24 hrs. the vesicles appear and these form into pustules which form scab and fall off in a few days. þvirus is shed from the respiratory tract and the pox. þvirus sequestered in neural ganglia and remains latent. 13 9/25/2021

varicella in adults can be life threatening. In pregnancy it can cause fetal infection and congenital varicella syndrome. 14 9/25/2021

Chickenpox: Diagnosis þclinical appearance þantibody titres 15 9/25/2021

Chickenpox Treatment þusually is not treated. þAcyclovir is used to treat disseminated infection in immunocompromised patients. þointments are used to relieve itching and bacterial infection of the lesions. 16 9/25/2021

prevention and control þliving attenuated vaccine is available for immunocompetent children at high risk. 17 9/25/2021

Shingles 18 9/25/2021

Shingles þdisease of adults. þgreater than 65% are >45 yrs. þreactivation can occur at any age and immunocompromised persons are high risk. 19 9/25/2021

Herpes zoster 20 9/25/2021

Herpes zoster 21 9/25/2021

Shingles Herpes zoster 22 9/25/2021

ZIG - Zoster Immune Globulin þThe antibodies are obtained from persons who have recently recovered from shingles. 23 9/25/2021

Shingles Diagnosis þfluorescent antibody for viral gene products. þtissue cultures are used for rapid diagnosis. þcells are grown for 24 to 72 hours. þscrapings of lesions can also be diagnosed with very specific fluorescent antibodies. þwomen have dysuria, urinary retention (involvement of urethra). þ 10% of individuals develop aseptic meningitis. 24 9/25/2021

Sacral radiculomyelitis þresults in neuralgias, urinary retention, obstipation (intractable constipation). -radiculitis is inflammation of the spinal nerve roots. -radiculomyelitis is inflammation of the nerve roots and spinal cord. -sacrum; the bones of the lower back. 25 9/25/2021