Henoch Schnleins Purpura General information Allergic vasculitis Children

Henoch Schönleins Purpura

General information Allergic vasculitis � Children between 3 and 10 years are mostly affected � 10 out of 100 000 children affected � Most likely infected during autumn and winter periods – upper airway infection � Hemorraghic rash, stomach, joints, kidneys �

Typical Symptoms � Skin �Maculopapular rash �Skin bleeding � Joints �Knees and ankles � GIT �Blood in faeces � Renal �Glomerulonephritis

Atypical Symptoms � CNS �Acute kidney failure �Intracerebral bleeding, edema or sinus vein thrombosis � Guillan Barré syndrome � Lungs � Scrotal � Coma edema

Causes � Uncertain � Vaccines, foods, drugs or medications �Typhoid, cholera, yellow fever, measles, hepatitis B �Antibiotics � Bacterial or viral infections � Not hereditary

Diagnosis � 5 criterias � 1. Not related to thrombocytopenia � 2. Abdominal pain * � 3. Histopathology – Ig. A � 4. Acute arthritis � 5. Proteinuria, hematuria *

Treatment In general, symptoms will improve themselves � Purpura, joint swellings, stomach ache can come and go for 2 months � Cortisone � Chronic glomerulonephritis treated by high dose of cortisone or cytostatic drugs. �

Prognosis � Very good � 1 -6 weeks � 35 % recurrence � 1 -3 % chronic renal failure /glomerulonephritis 1 % transplantation, dialysis

Fun fact Wolfgang Amadeus Mozart’s possible cause of death � Symptoms lasted for 15 days � The symptoms were pyrexia, polyarthritis, recurrent vomiting, exanthem, anasarca, near complete immobility and terminal coma. �