Hemorrhogic Fever Virus Hemorrhogic Fever Virus Hantaar Virus

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Hemorrhogic Fever Virus

Hemorrhogic Fever Virus

Hemorrhogic Fever Virus ¡ Hantaar Virus or HEMORRHAGIC FEVER with renal syndrome virus (

Hemorrhogic Fever Virus ¡ Hantaar Virus or HEMORRHAGIC FEVER with renal syndrome virus ( HFRS） ¡ Xing Jiang Hemorrhogic Fever Virus

Hantaar Virus (HEMORRHAGIC FEVER with renal syndrome virus )

Hantaar Virus (HEMORRHAGIC FEVER with renal syndrome virus )

Morphology ¡Spherical, 80 -120 nm ¡Nucleocapsid: Helical, 3 segments, 2 proteins - nucleocapsid ('N'),

Morphology ¡Spherical, 80 -120 nm ¡Nucleocapsid: Helical, 3 segments, 2 proteins - nucleocapsid ('N'), RNA polymerase ('L') ¡Envelope: 2 glycoproteins, G 1 and G 2,

Morphology

Morphology

Biological properties 1. ss. RNA with long, medium, short segments 2. Antigens 6 serotypes

Biological properties 1. ss. RNA with long, medium, short segments 2. Antigens 6 serotypes (I- VI) 3. Resistance: weak

Epidemiology 1. Natural host : rodents (deer mouse (Peromyscus maniculatus), cotton rat (Sigmodon hispidus),

Epidemiology 1. Natural host : rodents (deer mouse (Peromyscus maniculatus), cotton rat (Sigmodon hispidus), marsh rice rat (Oryzomys palustris) , white-footed mouse (Peromyscus leucopus), other carriers) 2. Transmission : Droplet and rodent excreta spread 3. Season and district

Clinical syndromes ¡ Headache; ¡ Pink in face , neck ¡ Fever ¡ marked

Clinical syndromes ¡ Headache; ¡ Pink in face , neck ¡ Fever ¡ marked bleeding tendency ¡ Lower blood pressure ¡ Urine with Protein ¡ multi-organ failure

Pathogenicity 1. Clinical manifestations: 5 phases ¡ Fever phase ¡ Hypotension phase ¡ Auria

Pathogenicity 1. Clinical manifestations: 5 phases ¡ Fever phase ¡ Hypotension phase ¡ Auria phase ¡ Polyuria phase ¡ convalescent phase

Pathogenesis ¡ Viral direct damage ¡ Immunopathogenesis

Pathogenesis ¡ Viral direct damage ¡ Immunopathogenesis

Laboratory diagnosis ¡ Cultivation: Vero-E 6 cell and A 549 cell ¡ Serological diagnosis:

Laboratory diagnosis ¡ Cultivation: Vero-E 6 cell and A 549 cell ¡ Serological diagnosis: Ig. M/Ig. G indirect immunofluorescent assay ELISA-Ig. M

Prevention and treatment ¡ Inactivated vaccine

Prevention and treatment ¡ Inactivated vaccine

Xing Jiang Hemorrhogic Fever Virus

Xing Jiang Hemorrhogic Fever Virus

Morphology ¡Spherical, 80 -120 nm ¡Nucleocapsid: Helical, 3 segments, 2 proteins - nucleocapsid ('N'),

Morphology ¡Spherical, 80 -120 nm ¡Nucleocapsid: Helical, 3 segments, 2 proteins - nucleocapsid ('N'), RNA polymerase ('L') ¡Envelope: 2 glycoproteins, G 1 and G 2,

Vector and Host ¡ Animal Host ¡ Hyalomma asiaticum

Vector and Host ¡ Animal Host ¡ Hyalomma asiaticum

Pathogenesis ¡ Season: April and May

Pathogenesis ¡ Season: April and May

Prevention ¡ Inactivated vaccine

Prevention ¡ Inactivated vaccine

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