Hematopoiesis specific loss of Cdk 2 and Cdk

Hematopoiesis specific loss of Cdk 2 and Cdk 4 results in increased erythrocyte size and delayed platelet recovery following stress by Senthil Raja Jayapal, Chelsia Qiuxia Wang, Xavier Bisteau, Matias J. Caldez, Shuhui Lim, Vinay Tergaonkar, Motomi Osato, and Philipp Kaldis haematol Volume 100(4): 431 -438 March 31, 2015 © 2015 by Ferrata Storti Foundation

Cdk 2 and Cdk 4 regulate erythroid cell size. Senthil Raja Jayapal et al. Haematologica 2015; 100: 431 -438 © 2015 by Ferrata Storti Foundation

Analysis of hematopoietic stem and progenitor cells (HSPCs) in Cdk 2 fl/fl. Cdk 4−/−vav. Cre (DKO) mice. Senthil Raja Jayapal et al. Haematologica 2015; 100: 431 -438 © 2015 by Ferrata Storti Foundation

Analysis of fetal liver erythroblasts lacking Cdk 2 and Cdk 4. Senthil Raja Jayapal et al. Haematologica 2015; 100: 431 -438 © 2015 by Ferrata Storti Foundation

Deletion of Rb rescued the increased erythrocyte size observed in Cdk 2 fl/fl. Cdk 4−/−vav. Cre (DKO) mice. Senthil Raja Jayapal et al. Haematologica 2015; 100: 431 -438 © 2015 by Ferrata Storti Foundation

Stress hematopoiesis in Cdk 2 fl/fl. Cdk 4−/−vav. Cre mice. Senthil Raja Jayapal et al. Haematologica 2015; 100: 431 -438 © 2015 by Ferrata Storti Foundation

Cdk 1 fl/flvav. Cre mice exhibit neonatal lethality due to hematopoietic failure. Senthil Raja Jayapal et al. Haematologica 2015; 100: 431 -438 © 2015 by Ferrata Storti Foundation