HEARTLUNG TRANSPLANTATION Overall 2017 JHLT 2017 Oct 3610

HEART-LUNG TRANSPLANTATION Overall 2017 JHLT. 2017 Oct; 36(10): 1037 -1079

Adult and Pediatric Heart-Lung Transplants Number of Transplants Reported by Location and Year 300 North America 250 Europe 200 150 100 50 0 19 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 2099 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 15 Number of Transplants Other 2017 JHLT. 2017 Oct; 36(10): 1037 -1079 NOTE: This figure includes only the heart-lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as evidence that the number of heart-lung transplants worldwide has declined in recent years.

Adult and Pediatric Heart-Lung Transplants Average Center Volume (Transplants: 2004 – June 2016) Percentage of transplants 70 70 60 60 50 50 40 40 30 60 30 43 20 10 9 3 0 1 2 3 4 -9 Average number of heart-lung transplants per year 2017 JHLT. 2017 Oct; 36(10): 1037 -1079 0 % of Heart-Lung Transplants (red line) Number of Centers Number of centers

Adult and Pediatric Heart-Lung Transplants Distribution of Transplants by Lung Center Volume (Transplants: 2004 – June 2016) % of Heart-Lung Transplants 30 25 20 15 10 5 0 1 -4 5 -9 10 -19 20 -29 30 -39 40 -49 Average number of lung transplants per year 2017 JHLT. 2017 Oct; 36(10): 1037 -1079 50+

Adult and Pediatric Heart-Lung Transplants Kaplan-Meier Survival by Age Group (Transplants: 1982 - June 2015) 100 Median survival (years): Adult = 3. 3, Pediatric = 3. 0 Conditional median survival (years): Adult = 10. 3, Pediatric = 7. 8 Survival (%) 75 p = 0. 6336 50 25 Adult (N=3, 953) Pediatric (N=719) 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 Years 2017 JHLT. 2017 Oct; 36(10): 1037 -1079