HEARTLUNG TRANSPLANTATION Overall 2015 JHLT 2015 Oct 3410

HEART-LUNG TRANSPLANTATION Overall 2015 JHLT. 2015 Oct; 34(10): 1264 -1277

Adult and Pediatric Heart-Lung Transplants Number of Transplants Reported by Location and Year 300 North America 250 Europe 200 150 100 50 0 19 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 2099 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 13 Number of Transplants Other 2015 JHLT. 2015 Oct; 34(10): 1264 -1277 JHLT. 2014 Oct; 33(10): 1009 -1024 NOTE: This figure includes only the heart-lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as evidence that the number of heart-lung transplants worldwide has declined in recent years.

Adult and Pediatric Heart-Lung Transplants Average Center Volume (Transplants: January 2004 – June 2014) Percentage of transplants 60 60 50 50 40 40 30 30 53 20 20 38 10 10 6 0 1 2 3 6 4 - 9 Average number of heart-lung transplants per year 2015 JHLT. 2015 Oct; 34(10): 1264 -1277 JHLT. 2014 Oct; 33(10): 1009 -1024 0 % of Heart-Lung Transplants Number of Centers Number of centers

Adult and Pediatric Heart-Lung Transplants Distribution of Transplants by Lung Center Volume (Transplants: January 2004 – June 2014) % of Heart-Lung Transplants 30 25 20 15 10 5 0 1 -4 5 -9 10 -19 20 -29 30 -39 40 -49 Average number of lung transplants per year 2015 JHLT. 2015 Oct; 34(10): 1264 -1277 JHLT. 2014 Oct; 33(10): 1009 -1024 50+

Adult and Pediatric Heart-Lung Transplants Kaplan-Meier Survival by Age Group (Transplants: January 1982 – June 2013) 100 Median survival (years): Adult = 3. 3, Pediatric = 3. 0 Conditional median survival (years): Adult = 10. 3, Pediatric = 7. 7 Survival (%) 80 60 p-value = 0. 4983 40 N at risk = 13 20 Adult (N=3, 762) Pediatric (N=688) N at risk = 11 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 Years 2015 JHLT. 2015 Oct; 34(10): 1264 -1277 JHLT. 2014 Oct; 33(10): 1009 -1024