HEART TRANSPLANTATION Overall 2015 JHLT 2015 Oct 3410

HEART TRANSPLANTATION Overall 2015 JHLT. 2015 Oct; 34(10): 1244 -1254

Adult and Pediatric Heart Transplants Number of Transplants by Year 5000 4000 3500 2000 1500 1000 500 187 322 671 1 261 2 357 2 998 3 525 3 822 4 528 4 754 4 735 4 939 4 838 4 802 4 683 4 602 4 515 4 200 4 110 4 044 3 913 3 838 3 807 3 936 4 001 4 013 4 042 4 071 4 163 4 233 4 254 4 477 3000 0 19 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 2099 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 13 Number of transplants 4500 2015 JHLT. 2015 2014 Oct; 34(10): 33(10): 1244 -1254 996 -1008 NOTE: This figure includes only the heart transplants that are reported to the ISHLT Transplant Registry. As such, the presented data may not mirror the changes in the number of heart transplants performed worldwide.

Adult and Pediatric Heart Transplants Number of Transplants by Year and Location 5000 4000 Other Europe North America 3500 3000 2500 2000 1500 1000 500 0 19 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 2099 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 13 Number of transplants 4500 2015 JHLT. 2015 2014 Oct; 34(10): 33(10): 1244 -1254 996 -1008 NOTE: This figure includes only the heart transplants that are reported to the ISHLT Transplant Registry. As such, the presented data may not mirror the changes in the number of heart transplants performed worldwide.

Adult and Pediatric Heart Transplants Average Center Volume (Transplants: January 2009 – June 2014) Percentage of transplants 120 60 100 50 80 40 60 30 116 40 20 20 44 55 41 0 1 -4 5 -9 10 -19 20 -29 10 13 5 7 3 30 -39 40 -49 50 -74 75+ Average number of heart transplants per year 2015 JHLT. 2015 2014 Oct; 34(10): 33(10): 1244 -1254 996 -1008 0 % of transplants Number of centers

Adult and Pediatric Heart Transplants Recipient Age by Year of Transplant 18 -39 40 -59 60 -69 70+ Median Age 120% 60 100% 50 80% 40 60% 30 40% 20 20% 10 0% 0 2015 JHLT. 2015 2014 Oct; 34(10): 33(10): 1244 -1254 996 -1008 Median recipient age (years) 10 -17 19 8 19 2 8 19 3 8 19 4 8 19 5 8 19 6 8 19 7 8 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 13 % of transplants 0 -9

Adult and Pediatric Heart Transplants Median Recipient Age by Location Europe North America Other 55 50 45 8 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 13 40 19 Median recipient age (years) 60 2015 JHLT. 2015 2014 Oct; 34(10): 33(10): 1244 -1254 996 -1008

Adult and Pediatric Heart Transplants Donor Age by Year of Transplant 18 -39 40 -59 60 -69 70+ Median Age 120% 35 100% 30 25 80% 20 60% 15 40% 10 20% 5 0% 0 2015 JHLT. 2015 2014 Oct; 34(10): 33(10): 1244 -1254 996 -1008 Median donor age (years) 10 -17 19 8 19 2 8 19 3 8 19 4 8 19 5 8 19 6 8 19 7 8 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 13 % of transplants 0 -9

Adult and Pediatric Heart Transplants Median Donor Age by Location Europe North America Other 45 40 35 30 25 8 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 13 20 19 Median donor age (years) 50 2015 JHLT. 2015 2014 Oct; 34(10): 33(10): 1244 -1254 996 -1008

Adult and Pediatric Heart Transplants Recipient Age Distribution By Era 70 1982 -1998 (N=57, 137) % of transplants 60 50 1999 -2008 (N=39, 879) 2009 -6/2014 (N=22, 781) 40 p < 0. 0001 30 20 10 0 0 -9 10 -17 18 -39 40 -59 Recipient Age 2015 JHLT. 2015 2014 Oct; 34(10): 33(10): 1244 -1254 996 -1008 60 -69 70+

Adult and Pediatric Heart Transplants Donor and Recipient Age (Transplants: January 2009 – June 2014) Donor Age: 0 -9 10 -17 18 -39 40 -59 60 -69 70+ 100% % of transplants 80% 60% 40% 20% 0% 0 -9 10 -17 18 -39 40 -59 Recipient Age 2015 JHLT. 2015 2014 Oct; 34(10): 33(10): 1244 -1254 996 -1008 60 -69 70+

Adult and Pediatric Heart Transplants Donor and Recipient Age (Transplants: January 2009 – June 2014) Recipient Age: 0 -9 10 -17 18 -39 40 -59 60 -69 70+ 100% % of transplants 80% 60% 40% 20% 0% 0 -9 10 -17 18 -39 40 -59 Donor Age 2015 JHLT. 2015 2014 Oct; 34(10): 33(10): 1244 -1254 996 -1008 60 -69 70+

Adult and Pediatric Heart Transplants Recipient Age Distribution by Location (Transplants: January 2009 – June 2014) 0 -9 10 -17 18 -39 40 -59 60 -69 70+ 100% % of recipients 80% 60% 40% 20% 0% Europe North America 2015 JHLT. 2015 2014 Oct; 34(10): 33(10): 1244 -1254 996 -1008 Other Recipient age (years): mean/median Europe = 47/52 North America = 45/53 Other = 44/48

Adult and Pediatric Heart Transplants Donor Age Distribution by Location (Transplants: January 2009 – June 2014) 0 -9 10 -17 18 -39 40 -59 60 -69 70+ 100% % of donors 80% 60% 40% 20% 0% Europe North America 2015 JHLT. 2015 2014 Oct; 34(10): 33(10): 1244 -1254 996 -1008 Other Donor age (years): mean/median Europe = 40/43 North America = 28/27 Other = 32/30

Adult and Pediatric Heart Transplants Donor and Recipient Age (Transplants: January 2009 – June 2014) 80 70 Donor Age 60 50 40 30 20 10 0 0 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 80 Recipient Age 2015 JHLT. 2015 2014 Oct; 34(10): 33(10): 1244 -1254 996 -1008 R 2 = 0. 25, p < 0. 0001 85

Adult and Pediatric Heart Transplants Kaplan-Meier Survival (Transplants: January 1982 – June 2013) 100 Median survival = 11 years Median survival conditional on surviving 1 st year = 13 years Survival (%) 75 50 N = 112, 521 N at risk at 30 years = 16 25 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 Years 2015 JHLT. 2015 2014 Oct; 34(10): 33(10): 1244 -1254 996 -1008

Adult and Pediatric Heart Transplants Kaplan-Meier Survival by Age Group (Transplants: January 1982 – June 2013) 100 Adult (N=100, 806) Pediatric (N=11, 384) Survival (%) 75 p < 0. 0001 50 25 Median survival (years): Adult=10. 3; Conditional=13. 0 Pediatric=15. 3; Conditional=20. 0 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Years 2015 JHLT. 2015 2014 Oct; 34(10): 33(10): 1244 -1254 1009 -1024