HEART TRANSPLANTATION Overall 2013 JHLT 2013 Oct 3210

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HEART TRANSPLANTATION Overall 2013 JHLT. 2013 Oct; 32(10): 951 -964

HEART TRANSPLANTATION Overall 2013 JHLT. 2013 Oct; 32(10): 951 -964

Adult and Pediatric Heart Transplants Number of Transplants by Year 5000 4000 3500 2000

Adult and Pediatric Heart Transplants Number of Transplants by Year 5000 4000 3500 2000 1500 1000 500 0 187 322 671 1, 261 2, 358 2, 997 3, 526 3, 818 4, 511 4, 720 4, 681 4, 874 4, 781 4, 762 4, 631 4, 543 4, 466 4, 169 4, 079 4, 015 3, 896 3, 819 3, 788 3, 884 3, 941 3, 957 3, 948 3, 980 4, 076 4, 096 3000 19 8 19 2 8 19 3 8 19 4 8 19 5 8 19 6 8 19 7 8 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 11 Number of transplants 4500 2013 JHLT. 2013 Oct; 32(10): 951 -964 NOTE: This figure includes only the heart transplants that are reported to the ISHLT Transplant Registry. As such, the presented data may not mirror the changes in the number of heart transplants performed worldwide.

Adult and Pediatric Heart Transplants Number of Transplants by Year and Location 5000 4000

Adult and Pediatric Heart Transplants Number of Transplants by Year and Location 5000 4000 Other Europe North America 3500 3000 2500 2000 1500 1000 500 0 19 8 19 2 8 19 3 8 19 4 8 19 5 8 19 6 8 19 7 8 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 11 Number of transplants 4500 2013 JHLT. 2013 Oct; 32(10): 951 -964 NOTE: This figure includes only the heart transplants that are reported to the ISHLT Transplant Registry. As such, the presented data may not mirror the changes in the number of heart transplants performed worldwide.

Adult and Pediatric Heart Transplants 110 55 100 50 90 45 80 40 70

Adult and Pediatric Heart Transplants 110 55 100 50 90 45 80 40 70 35 60 50 40 30 20 30 109 25 20 66 15 48 40 10 10 0 1 -4 5 -9 10 -19 20 -29 11 4 8 1 30 -39 40 -49 50 -74 75+ Average number of heart transplants per year Number of centers Percentage of transplants 2013 JHLT. 2013 Oct; 32(10): 951 -964 5 0 % of transplants Number of centers Average Center Volume (Transplants: January 2006 – June 2012)

8 19 2 8 19 3 8 19 4 8 19 5 8 19

8 19 2 8 19 3 8 19 4 8 19 5 8 19 6 8 19 7 8 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 11 19 % of transplants 120% 60 100% 50 80% 40 60% 30 40% 20 20% 10 0% 0 0 -9 10 -17 18 -39 40 -59 2013 JHLT. 2013 Oct; 32(10): 951 -964 60 -69 70+ Median Age Median age (years) Adult and Pediatric Heart Transplants Recipient Age by Year of Transplant

Adult and Pediatric Heart Transplants Median Recipient Age by Location 50 40 30 20

Adult and Pediatric Heart Transplants Median Recipient Age by Location 50 40 30 20 10 Europe North America Other 88 19 89 19 90 19 91 19 92 19 93 19 94 19 95 19 96 19 97 19 98 19 99 20 00 20 01 20 02 20 03 20 04 20 05 20 06 20 07 20 08 20 09 20 10 20 11 0 19 Median donor age (years) 60 2013 JHLT. 2013 Oct; 32(10): 951 -964

19 8 19 2 8 19 3 8 19 4 8 19 5 8

19 8 19 2 8 19 3 8 19 4 8 19 5 8 19 6 8 19 7 8 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 11 % of transplants 120% 35 100% 30 80% 25 20 60% 15 40% 10 20% 5 0% 0 0 -9 10 -17 18 -39 40 -59 2013 JHLT. 2013 Oct; 32(10): 951 -964 60 -69 70+ Median Age Median donor age (years) Adult and Pediatric Heart Transplants Donor Age by Year of Transplant

Adult and Pediatric Heart Transplants Median Donor Age by Location 50 40 35 30

Adult and Pediatric Heart Transplants Median Donor Age by Location 50 40 35 30 25 20 15 10 5 Europe North America Other 88 19 89 19 90 19 91 19 92 19 93 19 94 19 95 19 96 19 97 19 98 19 99 20 00 20 01 20 02 20 03 20 04 20 05 20 06 20 07 20 08 20 09 20 10 20 11 0 19 Median donor age (years) 45 2013 JHLT. 2013 Oct; 32(10): 951 -964

Adult and Pediatric Heart Transplants Recipient Age Distribution By Era % of transplants 65

Adult and Pediatric Heart Transplants Recipient Age Distribution By Era % of transplants 65 60 1982 -1995 (N = 43, 210) 55 1996 -2005 (N = 41, 266) 50 45 2006 -6/2012 (N = 25, 725) 40 35 p < 0. 0001 30 25 20 15 10 5 0 0 -9 10 -17 18 -39 40 -59 Recipient age 2013 JHLT. 2013 Oct; 32(10): 951 -964 60 -69 70+

Adult and Pediatric Heart Transplants Donor and Recipient Age (Transplants: January 2006 – June

Adult and Pediatric Heart Transplants Donor and Recipient Age (Transplants: January 2006 – June 2012) Donor Age: 0 -9 10 -17 18 -39 40 -59 60 -69 70+ 100% % of Transplants 80% 60% 40% 20% 0% 0 -9 10 -17 18 -39 40 -59 Recipient Age 2013 JHLT. 2013 Oct; 32(10): 951 -964 60 -69 70+

Adult and Pediatric Heart Transplants Donor and Recipient Age (Transplants: January 2006 – June

Adult and Pediatric Heart Transplants Donor and Recipient Age (Transplants: January 2006 – June 2012) Recipient Age: 0 -9 10 -17 18 -39 40 -59 60 -69 70+ 100% % of Transplants 80% 60% 40% 20% 0% 0 -9 10 -17 18 -39 40 -59 Donor Age 2013 JHLT. 2013 Oct; 32(10): 951 -964 60 -69 70+

Adult and Pediatric Heart Transplants Recipient Age Distribution by Location (Transplants: January 2006 –

Adult and Pediatric Heart Transplants Recipient Age Distribution by Location (Transplants: January 2006 – June 2012) 0 -9 10 -17 18 -39 40 -59 60 -69 70+ 100% % of Recipients 80% 60% 40% 20% 0% Europe North America 2013 JHLT. 2013 Oct; 32(10): 951 -964 Other Recipient age (years): mean/median Europe = 46/51 North America = 45/52 Other = 43/48

Adult and Pediatric Heart Transplants Donor Age Distribution by Location (Transplants: January 2006 –

Adult and Pediatric Heart Transplants Donor Age Distribution by Location (Transplants: January 2006 – June 2012) 0 -9 10 -17 18 -39 40 -59 60 -69 70+ 100% % of Donors 80% 60% 40% 20% 0% Europe North America 2013 JHLT. 2013 Oct; 32(10): 951 -964 Other Donor age (years): mean/median: Europe = 38/41 North America = 28/26 Other = 31/28

Adult and Pediatric Heart Transplants Donor and Recipient Age (Transplants: January 2006 – June

Adult and Pediatric Heart Transplants Donor and Recipient Age (Transplants: January 2006 – June 2012) 90 80 Donor Age 70 60 50 40 30 20 10 0 0 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 Recipient Age 2013 JHLT. 2013 Oct; 32(10): 951 -964 R 2 = 0. 24, p < 0. 0001 80

Adult and Pediatric Heart Transplants Kaplan-Meier Survival (Transplants: January 1982 – June 2011) 100

Adult and Pediatric Heart Transplants Kaplan-Meier Survival (Transplants: January 1982 – June 2011) 100 Median survival = 11 years Median survival conditional on surviving 1 st year= 13 years Survival (%) 75 50 N = 103, 299 N at risk at 26 years = 117 25 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 Years 2013 JHLT. 2013 Oct; 32(10): 951 -964