Headquarters Royal Free London NHS Foundation Trust UK

Headquarters | Royal Free London NHS Foundation Trust | UK | Pancreas. Group. org

• Mortality after pancreatic surgery has reduced significantly • Morbidity still remains high. • Outcomes after pancreatic surgery may be influenced by • patient selection • centre and surgeon experience • Patient factors: More patients experience postoperative complications related to their comorbidity. • Variation of the surgical management Headquarters | Royal Free London NHS Foundation Trust | UK | Pancreas. Group. org

• The aim of Pancreas. Group. org is to identify: • The true morbidity and mortality • Modifiable predicting factors of outcomes after pancreatic surgery. Headquarters | Royal Free London NHS Foundation Trust | UK | Pancreas. Group. org

”Snapshot” collaborative study: • 3 -month patient recruitment • 3 -month postoperative follow up • within a 1 -year frame period (2021) worldwide 3 -month patient recruitment Jan 90 -day patient follow up 2021 Headquarters | Royal Free London NHS Foundation Trust | UK | Pancreas. Group. org Dec

e. g. 1 90 -day patient follow up 3 -month patient recruitment Jan May March Dec 2021 90 -day patient follow up 3 -month patient recruitment e. g. 2 Jan July March Dec 2021 90 -day patient follow up 3 -month patient recruitment e. g. 3 Jan Oct 2021 Feb Dec 2022 Headquarters | Royal Free London NHS Foundation Trust | UK | Pancreas. Group. org …

Registration open to all surgeons performing pancreatic surgery • No minimum number of cases to be submitted • No selection criteria for centres Headquarters | Royal Free London NHS Foundation Trust | UK | Pancreas. Group. org

Inclusion criteria: • All indications (including benign and malignant) • Open, laparoscopic or robotic. • Elective or emergency. • Partial or total pancreatectomies. • Pancreatic tumour enucleations. • Procedures with concomitant vascular or other organ resections. • Pancreatic duct drainage procedures (e. g. Frey, Puestow, or Beger) • Adults 18 years of age or older. Headquarters | Royal Free London NHS Foundation Trust | UK | Pancreas. Group. org

Exclusion criteria: • Pancreas or islet cell transplantation. • Transcutaneous or transgastric imaging-guided ablation (e. g. RFA) or electroporation (e. g. Nano. Knife). • Endoscopic (e. g. ERCP, stent or lithotripsy) procedures. • Endoscopic transgastric and surgical necrosectomies excluded. • Patients less than 18 years of age excluded. Headquarters | Royal Free London NHS Foundation Trust | UK | Pancreas. Group. org

Outcomes: • Primary endpoint: 90 -day mortality • Secondary endpoints (among others): • 90 -day postoperative rates of pancreatic fistula • endocrine or exocrine insufficiency • type and Clavien-Dindo grade of complications • Comprehensive Complication Index® (CCI®) • length of hospital stay • hospital readmission rates • R 1/R 2 resections Headquarters | Royal Free London NHS Foundation Trust | UK | Pancreas. Group. org

Data ownership: • The headquarters at the Royal Free Hospital in London, UK will act as the custodian of the data. • The Scientific and Management committees together will decide after the publication of the main report about requests regarding secondary analysis and will consider all such requests based on quality and the validity of the proposed project and decide by majority decision. • All participants will be able to download their own submitted data in excel format without any need for permission from the study sponsor. Headquarters | Royal Free London NHS Foundation Trust | UK | Pancreas. Group. org

Authorship: • A single analysis and reporting without hierarchical authorship (no first author, no last author) is planned at the end of the study (a “pure” group author publication) to reflect the collaborative effort, in keeping with other global snapshot studies. • All collaborators will be Pub. Med cited in the main publication as well as in any future studies. • Spin-off studies may include formal authorship but must include the “Pancreas. Group. org Collaborative” citing all participants. Headquarters | Royal Free London NHS Foundation Trust | UK | Pancreas. Group. org

”Snapshot" study on pancreatic surgery worldwide over 3 months Provide a verified record of true morbidity and mortality Identify predicting factors of outcome after pancreatic surgery Study period January to December 2021 Obtain Pub. Med citable co-authorship Pancreas. Group. org Collaborative Headquarters | Royal Free London NHS Foundation Trust | UK | Pancreas. Group. org