HAEMORRHAGE BLOOD TRANSFUSION By Col Abrar Hussain Zaidi

HAEMORRHAGE & BLOOD TRANSFUSION By; Col Abrar Hussain Zaidi

SEQUENCE INTRODUCTION importance physiology/homeostasis integrity of circulatory system TYPES/CAUSES CONTROLE METHODS BLOOD TRANSFUSION

INTRODUCTION

INTRODUCTION Definitions Haemorrhage--bleeding Escape of blood from a blood-vessel Exsanguination- total loss of blood Desanguination- major loss of blood [Encyclopedia Britannica]

INTRODUCTION Subject’s importance Haemorrhage is one of the basic problems and considerations in surgery From-trivial trauma or major abdominal organ injuries-to- congenital and acquired coagulation disorders A wide spectrum of problems involves haemorrhage Transfusion of blood is the main remedy

INTRODUCTION • • • Clinical Situation Trauma /accidents General operatiove interventions Gynaecological procedures Congenital coagulation disorders Acquired coagulation disorders Dic Anticoagulants Fulminent sepsis Mof • Common surgical conditions pres w bleed Intracranial haemorrhages/cva Upper git bleed/haemetemesis and melena Bleeding haeorrhoids Chronic wounds Anal fissures Aneurysms

INTRODUCTION Physiology • BODY’S SYSTEM OF HOMEOSTSIS • INTEGRITY OF EVERY SYSTEM ANATOMICAL FUNCTIONAL

INTRODUCTION Claude Bernard’s concepts French physiologist Claude Bernard (18131878), the founder of experimental physiology and experimental pharmacology. Bernard believed that the body has mechanisms by which it seeks to maintain a stable internal environment despite changes in the external environment- Homeostasis [ 1851]

INTRODUCTION What Prevents Haemorrhage NATURAL BARRIERS AGAINST HAEMORRHAGE • • Integrity of vascular wall Coagulation system

INTRODUCTION Body’s response to haemorrhage/injury Attempts to repair the loss & restore normality There are several interrelated stages Local response / Gen response Aims at: • wall repair • Restoration of volume loss

INTRODUCTION Body’s response to haemorrhage/injury Virchow 1856 famous triad: • 1. Stasis • 2. Endothelial damage • 3. Hypercoaguable states local • Vasoconstriction • Platelet aggregation and plug formation • Coagulation leading to Fibrin formation –Intrinsic & Extrinsic Paths General • Compartmental Volume movement

PATHOLOGICAL BASIS OF HAEMORRHAGE BLEEDING CAN RESULT DUE TO: LOSS OF INTEGRITY OF WALL TRAUMA/OERATIONS COAGULATION DEFECTS CONGENITAL - H. PH AQUIRED -DIC

ETIOLOGY OF HAEMORRHAGE CAUSES OF HAEMORRHAGE • • INJURY /TRAUMA [+ operations]-It commonly results in tearing or cutting of a blood-vessel-integrity of wall breached - Trivial OR Major DISEASES that alter coagulation Congenital –platelet defects Coagulation factor defects Acquired scurvy Sepsis DIC

TYPES OF HAEMORRHAGE • • • AMOUNT OF LOSS --MINOR/MAJOR ACUTE/CHRONIC ARTERIAL/VENOUS/CAPILLARY/MIXED LOCALIZED/DIFFUSE EXTERNAL/ INTERNAL OVERT/OCCULT

TYPES OF HAEMORRHAGE Bleeding from an artery is of a bright red colour, and escapes from the end of the vessel nearest the heart in jets synchronous with the heart's beat Bleeding from a vein is of a darker colour; the flow is steady, the bleeding is from the distal end of the vessel. Capillary bleeding is a general oozing from a raw surface.

TYPES OF HAEMORRHAGE SPECIFIC TYPES • Bruise or ecchymosis. Extravasation of blood /pouring out of blood into the areolar tissues, which become boggy • • Haematemesis and melena Haemoptysis. Haematuria Epistaxis

TYPES OF HAEMORRHAGE CLASSIFICATION OF SURGICAL HAEMORRHAGE Haemorrhage has been classified as— 1 -Primary, occurring at the time of the injury 2 -Reactionary, or within twenty-four hours of the accident, during the stage of reaction 3 -Secondary, occurring at a later period and caused by faulty application of a ligature or septic condition of the wound. In severe haemorrhage, as from the division of a large artery, the patient may collapse and death ensue from syncope.

Hemorrhage -four classes American College of Surgeons' Advanced Trauma Life Support (ATLS) • Class I Hemorrhage involves up to 15% of blood volume. There is typically no change in vital signs and fluid resuscitation is not usually necessary. • Class II Hemorrhage involves 15 -30% of total blood volume. A patient is often tachycardic (rapid heart beat) with a narrowing of the difference between the systolic and diastolic blood pressures. The body attempts to compensate with peripheral vasoconstriction. Skin may start to look pale and be cool to the touch. The patient may exhibit slight changes in behavior. Volume resuscitation with crystalloids (Saline solution or Lactated Ringer's solution) is all that is typically required. Blood transfusion is not typically required.

Hemorrhage -four classes American College of Surgeons' Advanced Trauma Life Support (ATLS • Class III Hemorrhage involves loss of 30 -40% of circulating blood volume. blood pressure drops, the heart rate increases, peripheral perfusion (shock), such as capillary refill worsens, and the mental status worsens. Fluid resuscitation with crystalloid and blood transfusion are usually necessary. • Class IV Hemorrhage involves loss of >40% of circulating blood volume. The limit of the body's compensation is reached and aggressive resuscitation is required to prevent death.

NB Fit Individuals may have more effective compensatory mechanisms before experiencing cardiovascular collapse. These patients may look deceptively stable, with minimal derangements in vital signs, while having poor peripheral perfusion. Elderly patients or those with chronic medical conditions may have less tolerance to blood loss, less ability to • compensate, and may take medications such as betablockers that can potentially blunt the cardiovascular response. Care must be taken in the assessment of these patients.

EFFECTS OF HAEMORRHAGE Depend upon following: • Acute loss vs Chronic loss • The amount of loss • The compensatory mechanisms • General state of health

EFFECTS OF HAEMORRHAGE Depends upon the amount of blood loss Stages of Hypovolemia Stage 1 • Up to 15% blood volume loss (750 mls) • Compensated by constriction of vascular bed • Blood pressure maintained • Normal respiratory rate • Pallor of the skin • Slight anxiety

EFFECTS OF HAEMORRHAGE Stage 2 • 15 -30% blood volume loss (750 - 1500 mls) • Cardiac output cannot be maintained by arterial constriction • Tachycardia >100 bpm • Increased respiratory rate • Blood pressure maintained • Increased diastolic pressure • Narrow pulse pressure • Sweating from sympathetic stimulation • Mildly anxious/Restless

EFFECTS OF HAEMORRHAGE Stage 3 • 30 -40% blood volume loss (1500 - 2000 mls) • Systolic BP falls to 100 mm. Hg or less • Classic signs of hypovolemic shock • Marked tachycardia >120 bpm • Marked tachypnoea >30 bpm • Decreased systolic pressure • Alteration in mental status (Anxiety, Agitation) • Sweating with cool, pale skin

EFFECTS OF HAEMORRHAGE Stage 4 -----Shock • Loss greater than 40% (>2000 mls) • Extreme tachycardia with weak pulse • Pronounced tachypnoea • Significantly decreased systolic blood pressure of 70 mm. Hg or less • Decreased level of consciousness • Skin is sweaty, cool, and extremely pale (moribund)

MANAGEMENT OF HAEMORRHAGE • • Prevention Precautions during surgery Operative method of control of haemorrhage Blood Transfusion

SURGICAL HAEMOSTASIS NATURAL OR ARTIFICIAL Natural CONTROLE/arrest of haemorrhage arises from ; (1) the coagulation of the blood itself, (2) the diminution of the heart's action as in fainting, (3) changes taking place in the cut vessel causing its retraction and contraction.

SURGICAL HAEMOSTASIS EXTERNAL HAEMORRHAGE /WOUNDS The surgical procedure for the treatment of an open wound is(1) arrest of haemorrhage; (2) cleansing of the wound and removal of any foreign bodies; (3) careful apposition of its edges and surfaces— sutures of aseptic silk or catgut, the surfaces by carefully applied pressure; (4) free drainage, if necessary, to prevent accumulation either of blood or serous effusion; (S) avoidance of sepsis; (6) perfect rest of the part.

SURGICAL HAEMOSTASIS Surgical treatment of haemorrhage minor means of arresting bleeding are: cold, which is most valuable in general oozing and local extravasations; very hot water, 130° to 16 o F. , a powerful haemostatic; position, such as elevation of the limb, valuable in bleeding from the extremities; styptics or astringents, applied locally, as perchloride of iron, tannic acid and others, the most valuable being suprarenal extract.

SURGICAL HAEMOSTASIS Surgical treatment of haemorrhage DIRECT PRESSURE In small blood-vessels pressure will be sufficient to arrest. haemorrhage permanently. LIGATURE In large vessels with a reef-knot main artery of the limb exposed by dissection at the most accessible point.

SURGICAL HAEMOSTASIS Surgical treatment of haemorrhage • Diathermy • Sutures • Harmonic devices

TRANSFUSION MANAGEMENT • Early recognition of significant blood loss • it is commoner to see patients who have been undertransfused than over-transfused. I • t is essential to pay attention to and act on recordings of pulse rate and blood pressure. • In a fit patient without cardiac disease, persistent tachycardia − even if blood pressure is maintained − is likely to indicate continuing blood loss.

SURGICAL HAEMOSTASIS INTERNAL HAEMORRHAGE /WOUNDS Causes • Penetrating wounds chest, abdomen, neck, limbs • Upper GI haemorrhage Bleeding. Ulcers • Lower GI haemorrhage Diverticulosis Haemorrhoids Carcinomas

SURGICAL HAEMOSTASIS INTERNAL HAEMORRHAGE /WOUNDS Principles of management Teat the primary cause Avoid irrevercible shock Flid electrolytes Blood and blood produvts

• Types of bleeding • • A subconjunctival hemorrhage is a common and relatively minor post-LASIK complication. • • The endoscopic image of linitis plastica, a type of stomach cancer leading to a leather bottle-like appearance with blood coming out of it.

RESPONSE IN INJURY Vasoconstriction is mediated through intrinsic mechanisms and various vasoactive agents (thromboxane A 2 and serotonin) released during platelet aggregation. COAGULATION SYSTEM • Virchow in 1856 described the famous triad: • 1. Stasis • 2. Endothelial damage • 3. Hypercoaguable states • The coagulation system is based on the coagulation cascade. The end points of this cascade include the formation of thrombin and fibrin. • Throughout this system there can be defects in the multiple enzymes or extrinsic factors contributing to its dysfunction. Fibrinolysis There is a delicate balance between formation and lysis of

Transfusion management • All patients require large-bore intravenous cannulas. Central venous pressure monitoring is valuable in major haemorrhage or if there is cardio-respiratory disease. • Haemoglobin concentration − interpretation • The haemoglobin can underestimate the extent of blood loss in cases of acute haemorrhage before haemodilution has occurred, or can overestimate it if the patient is already anaemic from chronic blood loss.

• Table 3. 2. Coagulation cascade Intrinsic • Contact Tissue factor + VIIa • XIa + VIII Common Pathway • Xa + V • IIa • Clot

• Gastrointestinal haemorrhage: haematemesis and melaena • Haematemesis: vomiting fresh red blood. • Coffee-ground vomiting: vomiting of altered black blood. • Melaena: the passage of black tarry stools. • Bleeding may be from oesophageal varices or from other sites (non-variceal bleeding). • Acute upper gastrointestinal (GI) bleeding affects 50 to 150 per 100, 000 of the population each year and accounts for a substantial proportion of all blood used in UK hospitals. In the UK in 1995, mortality was reported to be 11% in patients admitted to hospital because of bleeding and 33% in those who developed gastrointestinal bleeding while hospitalised for other reasons. In the west of Scotland in 1997, the corresponding figures were 8. 2% and 43%. Most deaths are in elderly patients with