GROUP R 14300 DIGITAL MICROFLUIDICS Peter Dunning Paulina
![MICROFLUIDIC PLATFORMS Major microfluidic platforms organized by liquid actuation [1]](https://slidetodoc.com/presentation_image_h2/9626901f671dd4be4188c4cccb17ad94/image-4.jpg "MICROFLUIDIC PLATFORMS Major microfluidic platforms organized by liquid actuation [1]")
![REFERENCES [1] Mark, D. , Haeberle, S. , Roth, G. , Von Stetten, F.](https://slidetodoc.com/presentation_image_h2/9626901f671dd4be4188c4cccb17ad94/image-9.jpg "REFERENCES [1] Mark, D. , Haeberle, S. , Roth, G. , Von Stetten, F.")
- Slides: 9
GROUP R 14300 – DIGITAL MICROFLUIDICS Peter Dunning Paulina Klimkiewicz Matthew Partacz Andrew Greeley Thomas Wossner Wunna Kyaw
MOTIVATION Need for point of care medical testing devices where access to conventional tests is restricted § Ex: Doctor’s Offices, Remote Areas, Battlefields A solution must be portable and cheap http: //gdb. voanews. com/6 C 27 D 536 -9955 -4670 -91 C 4 -101 E 2 D 5 A 6322_w 640_r 1_s. jpg
BACKGROUND Lab-on-a-chip devices are capable of miniaturizing and automating biological protocols. Devices suited for commercial use have yet to be developed. http: //2. imimg. com/data 2/GK/EX/MY-920622/micro-biological-testing-250 x 250. jpg http: //www. lionixbv. nl/technology-microfluidics. html
MICROFLUIDIC PLATFORMS Major microfluidic platforms organized by liquid actuation [1]
DIGITAL MICROFLUIDIC DEVICES Cross-section view of Digital Microfluidic device. Dotted line indicates the shape of the meniscus before actuation. Modified from [2] “The electrowetting effect (in air)” [3] Array of electrodes which use the electrowetting effect to manipulate droplets. “Top view of flow on a ring structure” [3]
CUSTOMER REQUIREMENTS 1. 1 Droplet Manipulation Capable of creating droplets 1. 2 Droplet Manipulation Capable of splitting droplets 1. 3 Droplet Manipulation Capable of moving droplets 1. 4 Droplet Manipulation capable of Merging droplets 1. 5 Droplet Manipulation Repeatability of motion 1. 6 Droplet Manipulation Create a fast switching time 1. 6. 1 Droplet Manipulation Generate signal 1. 6. 2 Droplet Manipulation Control switches 2. 1 Monitoring Check location of droplet 2. 2 Monitoring Measure capacitance 2. 3 Monitoring Measure resistance 3. 1 Autonomization Follow a programmed sequence of instructions 3. 1. 1 Autonomization Visual interface to create and control droplet pathways 3. 2 Autonomization Multiplexing 3. 3 Autonomization Test for ELISA (Enzyme Linked Immunosorbant Assay)
CUSTOMER REQUIREMENT CONT. 4. 1 Fabrication Obtain benchmark droplet speed 4. 2 Fabrication Low cost 5. 1 Packaging Small 5. 2 Packaging Light weight 5. 3 Packaging Durable 5. 4 Packaging Reusable 5. 5 Packaging Package reagants with device 5. 6 Packaging User friendly 5. 7 Packaging Application based modularity 5. 8 Packaging Minimize evaporation (reagant dependent) 5. 8. 1 Packaging Control humidity of system 5. 8. 2 Packaging Control temperature of device 5. 9 Packaging Visually accessible 5. 10 Packaging Clean environment
Outstanding VOC § We will be meeting with Dr. Schertzer in the near future to confirm these requirements. Questions for Audience § Are our goals for this project clearly defined? § Do you have some understanding of how Digital Microfluidic Devices work?
REFERENCES [1] Mark, D. , Haeberle, S. , Roth, G. , Von Stetten, F. , and Zengerle, R. , 2010, "Microfluidic Lab-on-a-Chip Platforms: Requirements, Characteristics and Applications, " Chemical Society Reviews, 39(3), pp. 1153 -1182. [2] Cho, S. K. , Moon, H. J. , and Kim, C. J. , 2003, "Creating, Transporting, Cutting, and Merging Liquid Droplets by Electrowetting-Based Actuation for Digital Microfluidic Circuits, " Journal of Microelectromechanical Systems, 12(1), pp. 70 -80. [3] Fair, R. , The Electrowetting Effect (in Air), February 1, http: //microfluidics. ee. duke. edu/
