Grant Writing Introduction u Overview u NIH of

Grant Writing Introduction u. Overview u. NIH of Grantwriting

Grant Writing Introduction Overview Why Seek Funding? It: u. Provides resources (e. g. , time/money/RAs) to enable research. u. Attracts top students. u. Can enhance salary (up to 3 months funded summer support). u. Enables interdisciplinary (and other) collaborations (you can pay other people to work on the project). u. Often viewed as a measure of quality research by Deans and others. u. Facilitates tenure (required in some programs). u. Supports your unit/University (overhead, reputation). u. Enhances the reputation of communication field.

What are Potential Sources of Funding? Foundations/Corporate Sources of Funds + Internal University Resources u Overall possibilities: –http: //www. infoed. org/new_spin/spinmain. asp u Foundations http: //foundationcenter. org/findfunders/ http: //foundationcenter. org/pnd/rfp/cat_education. jhtml; jsessionid =XM UBUJN 4 SKHEPTQRSI 4 CGW 15 AAAACI 2 F For example Spencer foundationhttp: //www. spencer. org/programs/grants/research_grants. htm http: //www. agmconnect. org/RCP/guide 1. htm u Corporate http: //foundationcenter. org/findfunders/top 50 giving. html (top 50 corporate funders) http: //www. ncte. org/about/grants/sources/107742. htm • Internal funds http: //www/usc. edu/research/vice_provost/awards/zumberge. html

Do you have a Commercialization Partner? u Would the research you’d like to do be relevant to product development for commercialization? a marketing strategy? Validating the effectiveness of a product? Then the following might be a good way to go (especially if you have a corporate, experienced grant-getting partner with connections (e. g. , to DOD): – SBIR (Small Business Innovation Research) Award Mechanisms – STTR (Small Business Technology Transfer) Award Mechanisms

State Agencies (California) http: //www. ucop. edu/srphome/ u University AIDS Research Program – http: //uarp. ucop. edu/ u California Program Breast Cancer Research – http: //www. cbcrp. org/research/

Sources of Federal Government Funding http: //www. grants. gov/ http: //www. fedbizopps. gov/ http: //www. bnl. gov/techxfer/wfo_federal. asp u. National Science Foundation –http: //www. nsf. gov u. Dept. of Health and Human Resources –NIH http: //www. nih. gov –Office of Minority Health http: //www. cdc. gov/omh u. Substance Abuse & Mental Health Services Adm. –http: //www/samhsa. gov/index. aspx u. CDC –http: //www. cdc. gov u. Administration on Aging –http: //www. aoa. gov/

Sources of Federal Government Funding u. Defense Grants –http: //www. acq. osd. mil/ddre/research/ u. DTRA –http: //www. dtra. mil/ u. DARPA – http: //www. darpa. mil/ u. AFRL(AFOSR) –http: //www. afosr. af. mil/ u. ARO –http: //www. arl. army. mil/main/default. cfm? Action=29&Page=29 u. ONR –http: //www. onr. navy. mil/default. asp u. Department of Education –http: //www. ed. gov/index. jhtml –http: //www. ed. gov/fund/grant/apply/grantapps/index. html

Grant Funding u. What’s the Match? –What are you bringing to the table? –What do they want? How can you tell?

What’s the Match? You u What’s your 5 -year strategic plan for your career? u Funder u Who funds projects relevant to your goals? u What’s the match between your goals and How does this project fit agency’s goals/mission/ into it? funding priorities, constraints, cost/benefit – resources, expertise, skills have or could analysis? leverage, build? u Do they provide awarded grant abstracts to check on the match?

NIH • NIH: Funding Agency Focus • Background on NIH

How Are The NIH Institutes Organized? Director Intramural Director Extramural Director Intramural Program Extramural Program Research Laboratories on NIH Campus and Elsewhere Divisions/Centers/ Branches (Managing External Funding)

How Is The NIH Organized? NIH Extramural Funding Components INSTITUTES CENTERS National Cancer Institute (NCI) National Center for Complementary and National Alternative Medicine (NCCAM) National Institute on Aging (NIA) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Heart, Lung, and Blood Institute (NHLBI) Center for Research Resources (NCRR) John E. Fogarty International Center (FIC) National Center on Minority Health and Health Disparities (NCMHD) National Institute of Child Health and Human Development (NICHD) Warren Grant Magnuson Clinical Center (CC)* National Institute of Deafness and Other Communication Disorders (NIDCD) Center for Scientific Review (CSR) National Institute of Environmental Health Sciences (NIEHS) Center for Information Technology National Institute of Neurological Disorders and Stroke (NINDS) Division of Safety (DS)* National Library of Medicine (NLM) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institute of Dental and Craniofacial Research (NIDCR) National Eye Institute (NEI) National Institute of General Medical Sciences (NIGMS) National Institute of Mental Health (NIMH) National Institute for Nursing Research (NINR) National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Institute on Drug Abuse (NIDA) National Human Genome Research Institute (NHGRI) National Institute of Biomedical Imaging and Bioengineering (NIBIB) *Does not make Extramural Awards

NIH: Funding Agency Focus u. Which Agency will review your proposal? This could impact your funding success. Start with an overall description of each located here: http: //www. nih. gov/icd/ u

Which Agency at NIH? • Click on the link to the Center for Scientific Review • http: //cms. csr. nih. gov/ Under “Peer Review Meetings” select • Review group descriptions (check these out) • Study Section Rosters (click link); Check these people out! • Decide if there any RFA (set asides), RFPs (conracts) that might be relevant to your work you want to apply for, these might be funded by specific agencies. • Determine probability of funding via a given agency http: //grants 1. nih. gov/grants/award/success. htm • Check out grants funded by a given agency http: //crisp. cit. nih. gov/

Success Rates by Institutes http: //grants 1. nih. gov/grants/award/success/Success_By. IC. cfm (2005) Institute or Success Center Rate # Total Cost Awarded Success Rate NCI 6, 325 1, 292 439, 817, 442 20. 40% NIAAA 666 203 65, 869, 642 30. 50% NIAID 4611 1, 164 490, 432, 321 25. 20% NICHD 2, 835 505 142, 877, 320 17. 80% NIMH 2, 710 569 178, 136, 443 21. 00%

Which Award Mechanism? If you don’t already have your Ph. D. : u F 31 Minority Supplement (Must be African American, Hispanic, Native American, Alaskan Native, or Pacific Islander) or Supplement for disabled students. u F 30 Individual Predoctoral Awards (Must be enrolled in MD/Ph. D. program) u F 31 Predoctoral Fellowship Awards (Must have completed qualifying exams; for dissertation research/training) u Training Grants (faculty have to submit these but you could work on these with them)

Which Award Mechanism? If you have your Ph. D. and need more mentoring (new investigator- no prior NIH funding orange awards): K 01 Mentored Research Scientist Development Award (3 -5 years of additional supervised research) u K 25 Mentored Quantitative Research Career Development Award (if switching to biomedical field with background in statistics/math; previous background not focused on disease). • F 32 Individual Postdoctoral Fellowship (in similar field) u Don’t need 3 -5 years additional supervised research experience (but haven’t competed successfully for funding yet): u K 22: Career Transition Award u K 23: Mentored Patient-Oriented Research Career Development Award (need clinical doctoral degree or equivalent) • K 08: Mentored Clinical Scientist Development Award (Clinical Doctoral Degree) u K 24 Midcareer investigator award in Patient oriented researc • K 26 Midcareer investigator award in Mouse Pathobiology Research u RO 3: Small Grant (not much preliminary data) u R 01: Traditional Research Grants (note new investigator status if you are one) u R 15: Area grants (restricted by institutional NIH activity) u R 21: Exploratory/Developmental Research Grant (up to 275 K; 2 years) u

Agency Review Criteria (NIH) u u u Significance Approach Innovation Investigators Environment Other

Significance (also see Gerin, W. (2006). Writing the NIH Grant Proposal: A Step-by-Step Guide. Thousand Oaks, CA: Sage Publications; buy this book if you are thinking about writing an NIH grant-- very helpful!) Does the study address an important problem? u If the aims of the application are achieved, how will scientific knowledge or clinical practice be advanced? u What will be the effect of these studies on the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field? u

Approach Are the conceptual or clinical framework, design, methods, and analyses adequately developed, well integrated, well reasoned, and appropriate to the aims of the project? u Does the applicant acknowledge potential problem areas and consider u alternative tactics?

Innovation u Is the project original and innovative? – For example, does the project challenge existing paradigms or clinical practice? –Does it address an innovative hypothesis or critical barrier to progress in the field? –Does the project develop or employ novel concepts, approaches, methodologies, tools, or technologies for this area?

Investigators Are the investigators appropriately trained and well suited to carry out this work? u Is the work proposed appropriate to the experience level of the principal investigator (PI) and other researchers? u Does the investigative team bring complementary and integrated expertise to the project? u

Environment Does the scientific environment in which the work will be done contribute to the probability of success? u Do the proposed studies benefit from unique features of the scientific environment, or subject populations, or employ useful collaborative arrangements? u Is there evidence of institutional support? u

Other Protection of Human Subjects u Inclusion of Women, Minorities, and Children u Care and Use of Vertebrate Animals u Budget u Foreign applications u

First Step in Writing a New Grant What do we need to do? • Specific Aims (1 page) Include hypotheses/questions • Review Work Done (1 page) Include Preliminary work Include Literature review References (10+) • Think about/brainstorm regarding Pilot Studies (be able to talk about these) • Identify Grant Source Possibilities (consider criteria including possible success rates) • Identify Potential Reviewers (detail analysis of these individuals and chances of funding for alternative possibilities) How will this get done? By whom? In what order? How will you coordinate with one another and the PIs?