Gout Disease Dr Demet Demirciolu Gout The most
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Gout Disease Dr. Demet Demircioğlu
Gout • The most common cause of inflammatory arthritis in US adults (3. 9% of Americans; approx. 8. 3 million people; 2007 -2008) • Prevalence is greater in men (5. 9%; 6. 1 million) than women (2. 0%; 2. 2 million) • Prevalence has increased by 1. 2% points over the past 2 decades • Incidence of gout 2 x greater among black men than white men • Men with gout have been shown to have an increased risk of all-cause mortality and cardiovascular disease mortality
Pathophysiology • Caused by the deposition of monosodium urate crystals in tissues • Uric acid is a metabolic by-product of purine catabolism • Purines hypoxanthine uric acid • Reaction catalyzed by xanthine oxidase, found in the liver • When the balance of dietary intake, synthesis and rate of excretion are disrupted, hyperuricemia results – Overproduction (10%) – Underexcretion (90%) • Results in arthritis, soft tissue masses, nephrolithiasis and urate nephropathy
Pathophysiology Rees, F. et al. (2014) Optimizing current treatment of gout Nat. Rev. Rheumatol. doi: 10. 1038/nrrheum. 2014. 32
Risk Factors High Purine Diet (Red Meat, Fatty Poultry, High Fat Dairy, Seafood) Alcohol Consumption Trauma Osteoarthritis Surgery Starvation Dehydration Obesity Drugs (Allopurinol, uricosuric agents, thiazides, loop diuretics, low dose aspirin) • Renal Impairment • Genetic Mutations (SLC 22 A 9, SLC 22 A 12, ABCG 2) • • •
Stages of Gout • • Asymptomatic tissue deposition Acute Gouty Arthritis Intercritical Gout Chronic Articular and Tophaceous Gout
Acute Gout • Often presents as involvement of a single joint or multiple joints in the lower extremities: first metatarsophalangeal (podagra; 50% of people with gout), midtarsal, ankle and knee joints • Characterized by pain, erythema, swelling and warmth. Can have desquamation of skin. • Can even cause fever and leukocytosis • Maximal severity reached within 12 -24 hours • Even without treatment, attacks subside within days to several weeks
Chronic Gout • Characterized by chronic arthritis and tophi, resulting in chronic inflammatory and destructive changes
Renal Complications • Nephrolithiasis – Risk factors: increase uric acid excretion, reduced urine volume, and low urine p. H • Chronic urate nephropathy – Urate crystals can deposit in renal medullary interstitium producing inflammatory changes and fibrosis – Clinical features are non specific: renal function impairment, bland urinary sediment, mild proteinuria and serum urate concentrations often higher than expected for the degree of renal impairment. – Biopsy confirms diagnosis
Diagnosis • DDX: Pseudogout and Septic Arthritis
Diagnosis • 5 clinical classification criteria for gout currently exist: Rome, New York, ACR, Mexico and Netherlands • These classification criteria have not been extensively validated • Diagnosis should be based on combination of clinical, historical and laboratory data if arthrocentesis cannot be performed. Diagnosis is considered provisional.
Diagnosis • Arthrocentesis should be done in patients in whom the diagnosis has not been previously established. • Labs: cell count with differential, gram stain, culture, examination for crystals under polarized light microscopy
Treatment
Treatment
Treatment • When initiating urate lowering therapy, can precipitate acute gouty arthritis. Therefore, prophylaxis often given
Diet
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