Gonococcal Isolate Surveillance Project GISP California STD Surveillance

Gonococcal Isolate Surveillance Project (GISP) California STD Surveillance 2018 STD Control Branch 1

Gonococcal Isolate Surveillance Project (GISP), Percent of Neisseria Gonorrhoeae Isolates Obtained from Men who Have Sex with Men* in Five California STD Clinics, 1992– 2018 * Includes men who have sex with men only and men who have sex with men and women. Note: This project began in 2003 for the Los Angeles County STD Clinic. Project participation ended for the Long Beach City STD Clinic in 2007. Rev. 10/2019 STD Control Branch 2

Gonococcal Isolate Surveillance Project (GISP), Percent of Neisseria Gonorrhoeae Isolates with Decreased Susceptibility or Resistance to Ciprofloxacin in Five California STD Clinics, 1992– 2018 Note: Resistant isolates have minimum inhibitory concentrations (MICs) ≥ 1 μg ciprofloxacin/m. L. Isolates with decreased susceptibility have MICs of 0. 125 – 0. 5 μg ciprofloxacin/m. L. Orange, STD Clinic Sites: Long Beach (ended participation in 2007), Los Angeles (added in 2003), San Diego, San Francisco Rev. 10/2019 STD Control Branch 3

Gonococcal Isolate Surveillance Project (GISP), Percent of Neisseria Gonorrhoeae Isolates with CDC "Alert" Values for Azithromycin in California GISP STD Clinic Sites, 1992– 2018 Note: “Alert” values are set by CDC as markers to look at possible decreased susceptibility. Azithromycin alerts have minimum inhibitory concentrations (MICs) ≥ 2. 0 μg/m. L. No data before 1992. Orange, STD Clinic Sites: Long Beach (ended participation in 2007), Los Angeles (added in 2003), San Diego, San Francisco Rev. 10/2019 STD Control Branch 4

Gonococcal Isolate Surveillance Project (GISP), Percent of Neisseria Gonorrhoeae Isolates with CDC "Alert" Values for Azithromycin, by Sexual Orientation, in California GISP STD Clinic Sites, 1992– 2018 † MSM = Men who have sex with men only; MSM&W = Men who have sex with men and women MSW = Men who have sex with women only Rev. 10/2019 STD Control Branch 5

Gonococcal Isolate Surveillance Project (GISP), Percent of Neisseria Gonorrhoeae Isolates with CDC "Alert" Values for Selected Cephalosporins in California GISP STD Clinic Sites, 1992– 2018 * Cefixime susceptibility was not run in 2007 -2008. Note: “Alert” values are set by CDC as markers to look at possible decreased susceptibility. Cefixime alerts have minimum inhibitory concentrations (MICs) ≥ 0. 25 μg/m. L. Ceftriaxone alerts have MICs ≥ 0. 125 μg/m. L. STD Clinic Sites: Long Beach (ended participation in 2007), Los Angeles (added in 2003), Orange, Rev. 10/2019 San Diego, San Francisco STD Control Branch 6

Gonococcal Isolate Surveillance Project (GISP), Percent of Neisseria Gonorrhoeae Isolates with CDC "Alert" Values for Selected Cephalosporins, by Sexual Orientation, in California GISP STD Clinic Sites, 1992– 2018 † MSM = Men who have sex with men only; MSM&W = Men who have sex with men and women MSW = Men who have sex with women only * Cefixime susceptibility was not run in 2007 -2008. Rev. 10/2019 STD Control Branch 7