Glycogen Regulation AMP c AMP Ca 2 AMPKa

Glycogen Regulation Substrate Short Name GYS 1 Substrate Full Name Protein. Type Glycogen synthase,

Glycogen Regulation Substrate Full Name Short Name Protein. Type Substrate Phospho- Effect of Swissprot

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Glycogen Regulation AMP c. AMP Ca 2+ AMPKa 1 PKA p 38 a MAPK Grk 3 GSK 3 b PASK PHKg 1 DYRK 1 A DYRK 1 B DYRK 2 S 8 S 641 S 645 GYS 2 S 82 CK 1 MAPKAPK 2 S 15 S 8 S 11 S 645 PYGB PYGL PYGM GYS 1 Glycogen Degradation

Glycogen Regulation Substrate Short Name GYS 1 Substrate Full Name Protein. Type Glycogen synthase, muscle. Glygcogen synthesis enzyme Substrate Phospho- Effect of Kinase Swissprot site Phosphorylation Affecting P 13807 S 11 Phosphorylation inhibits CK 1 enzyme activity. P 13807 S 641 Phosphorylation inhibits DYRK 1 A enzyme activity. GYS 1 Glycogen synthase, muscle. Glygcogen synthesis enzyme P 13807 S 641 GYS 1 Glycogen synthase, muscle. Glygcogen synthesis enzyme P 13807 S 645 P 13807 S 8 GYS 1 Glycogen synthase, muscle. Glygcogen synthesis enzyme P 13807 S 8 GYS 1 All Kinases Affecting CK 1 Phosphatase Affecting DYRK 1 A, DYRK 1 B, DYRK 2, Grk 3, GSK 3 b, PASK Phosphorylation inhibits DYRK 1 B DYRK 1 A, enzyme activity. DYRK 1 B, DYRK 2, Grk 3, GSK 3 b, PASK Phosphorylation inhibits DYRK 2 DYRK 1 A, enzyme activity. DYRK 1 B, DYRK 2, Grk 3, GSK 3 b, PASK Phosphorylation inhibits Grk 3 DYRK 1 A, enzyme activity. DYRK 1 B, DYRK 2, Grk 3, GSK 3 b, PASK Phosphorylation inhibits GSK 3 b DYRK 1 A, enzyme activity. DYRK 1 B, DYRK 2, Grk 3, GSK 3 b, PASK Phosphorylation inhibits PASK DYRK 1 A, enzyme activity. DYRK 1 B, DYRK 2, Grk 3, GSK 3 b, PASK Phosphorylation inhibits Grk 3, GSK 3 b, p 38 b enzyme activity. MAPK Phosphorylation inhibits GSK 3 b Grk 3, GSK 3 b, p 38 b enzyme activity. MAPK Phosphorylation inhibits p 38 b MAPK Grk 3, GSK 3 b, p 38 b enzyme activity. MAPK Phosphorylation inhibits AMPKa 1, CK 1, enzyme activity. MAPKAPK 2, Ph. Kg, PKACa Phosphorylation inhibits CK 1 AMPKa 1, CK 1, enzyme activity. MAPKAPK 2, Ph. Kg, PKACa Phosphorylation inhibits MAPKAPK 2 AMPKa 1, CK 1, enzyme activity. MAPKAPK 2, Ph. Kg, PKACa Phosphorylation inhibits Ph. K-g AMPKa 1, CK 1, enzyme activity. MAPKAPK 2, Ph. Kg, PKACa

Glycogen Regulation Substrate Full Name Short Name Protein. Type Substrate Phospho- Effect of Swissprot site Phosphorylation GYS 1 Glycogen synthase, muscle. Glygcogen synthesis enzyme P 13807 S 8 GYS 2 Glycogen synthase, liver Glygcogen synthesis enzyme P 54840 S 641 GYS 2 Glycogen synthase, liver Glygcogen synthesis enzyme P 54840 S 641 GYS 2 Glycogen synthase, liver P 54840 S 645 GYS 2 Glycogen synthase, liver Glygcogen synthesis enzyme P 54840 S 8 GYS 2 Glycogen synthase, liver Glygcogen synthesis enzyme P 54840 S 8 Kinase All Kinases Affecting Phosphorylation inhibits PKACa enzyme activity. Phosphatase Affecting AMPKa 1, CK 1, MAPKAPK 2, Ph. Kg, PKACa Phosphorylation inhibits DYRK 1 A, enzyme activity. DYRK 1 B, DYRK 2, Grk 3, GSK 3 b, PASK Phosphorylation inhibits DYRK 1 B DYRK 1 A, enzyme activity. DYRK 1 B, DYRK 2, Grk 3, GSK 3 b, PASK Phosphorylation inhibits DYRK 2 DYRK 1 A, enzyme activity. DYRK 1 B, DYRK 2, Grk 3, GSK 3 b, PASK Phosphorylation inhibits Grk 3 DYRK 1 A, enzyme activity. DYRK 1 B, DYRK 2, Grk 3, GSK 3 b, PASK Phosphorylation inhibits GSK 3 b DYRK 1 A, enzyme activity. DYRK 1 B, DYRK 2, Grk 3, GSK 3 b, PASK Phosphorylation inhibits PASK DYRK 1 A, enzyme activity. DYRK 1 B, DYRK 2, Grk 3, GSK 3 b, PASK Phosphorylation inhibits Grk 3, GSK 3 b, p 38 b enzyme activity. MAPK Phosphorylation inhibits GSK 3 b Grk 3, GSK 3 b, p 38 b enzyme activity. MAPK Phosphorylation inhibits p 38 b MAPK Grk 3, GSK 3 b, p 38 b enzyme activity. MAPK Phosphorylation inhibits AMPKa 1, CK 1, enzyme activity. MAPKAPK 2, Ph. Kg, PKACa Phosphorylation inhibits CK 1 AMPKa 1, CK 1, enzyme activity. MAPKAPK 2, Ph. Kg, PKACa Phosphorylation inhibits MAPKAPK 2 AMPKa 1, CK 1, enzyme activity. MAPKAPK 2, Ph. Kg, PKACa Phosphorylation inhibits Ph. K-g AMPKa 1, CK 1, enzyme activity. MAPKAPK 2, Ph. Kg, PKACa

Glycogen Regulation Substrate Full Name Short Name Protein. Type Substrate Phospho- Effect of Swissprot site Phosphorylation GYS 2 Glycogen synthase, liver Glygcogen synthesis enzyme PHKG 1 Phosphorylase B kinase gamma catalytic subunit 1 Glycogen phosphorylase, brain form Glycogen phosphorylase, liver form Glycogen phosphorylase, muscle form Glygcogen regulation Q 16816 enzyme Glygcogen degradation P 11216 enzyme Glygcogen degradation P 06737 enzyme Glygcogen degradation P 11217 enzyme PYGB PYGL PYGM P 54840 Kinase All Kinases Affecting S 8 Phosphorylation inhibits PKACa enzyme activity. S 82 Phosphorylation may PKACa stimulate kinase activity. Glycogen phosphorylase, Ph. K-g brain form Glycogen phosphorylase, Ph. K-g liver form Glycogen phosphorylase, Ph. K-g muscle form S 15 AMPKa 1, CK 1, MAPKAPK 2, Ph. Kg, PKACa Ph. K-g Phosphatase Affecting