GIP Arronax and Subatech Nantes France Arronax Team

GIP Arronax and Subatech Nantes (France) Arronax Team: 44 FTE 1/3 on cyclotron 1/3 R&D/production 1/3 support PRISMA@Subatech: 8 researchers, 3 Ph. D students 1

Arronax: an Accelerator for Research in Radiochemistry and Oncology at Nantes Atlantique Arronax unique characteristics Multi-particles High energy High intensity 2 Beam Accelerated particles Energy range (Me. V) Intensity (eµA) Dual beam Proton H- 30 -70 <375 Yes HH+ 17 <50 No Deuteron D- 15 -35 <50 Yes Alpha He++ 68 <70 No

ARRONAX facility 6 experimental vaults P 3 P 2 AX A 2 P 1 A 1 4 vaults connected through a pneumatic system to the hot-cells 5 lines of hot cells 2 lines in a sterile environment 1 preclinical imaging platform in the vicinity Irradiation station 3 Hot cells

What we do Radionuclide production for nuclear medicine § 82 Sr (FDA approved) § 64 Cu, 67 Cu § 211 At § 44 Sc, … Radiopharmaceutical production for clinical trials § Using 177 Lu (2 studies on-going) § Using 64 Cu (1 study on-going) C. Huet / GIP Arronax Associated research fields Radiolysis, Radiobiology, Nuclear Physics, detector testing Training Shipping radionuclides (USA, France, CERN) Hosting researchers (France, Italy, Israel) 4

What can be provided ? Facility as key research infrastructure • Providing isotopes for end-users • Shipping to end-users • In house • Target irradiation for mass extraction elsewhere Proposed Isotopes: • 64 Cu (around 20 runs a year) – GMP agreement expected 2021 • 44 Sc and 67 Cu for preclinical use (monthly run) • Target irradiations – On demand this year 9 irradiations for CERN Beam time for tests : material sciences, detectors, … On demand 5

What can be provided ? Network activity: • We are part of several organization in france (GDR MI 2 B, Atlanpole Biotherapie, …) and working group of EANM (quality, radiation safety, …) • We can bring our expertise on radiopharmaceuticals, quality, GMP production and isotope production Joint research activity: • Work on target and material • Work on excitation scheme to be more specific with lasers • Work on ion sources (material selection, reusable, …) • Work on mass separation (multiple beam collection, …) 6

Thank you for your attention The ARRONAX project is supported by: the Regional Council of Pays de la Loire the Université de Nantes the French government (CNRS, INSERM) the European Union. This work has been, in part, supported by a grant from the French National Agency for Research called "Investissements d'Avenir", Equipex Arronax-Plus no. ANR-11 -EQPX-0004, Labex IRON no. ANR-11 -LABX-18 -01 and ISITE Next no. ANR-16 -IDEX-0007 MEDICIS-PROMED has been supported by a Marie Skłodowska-Curie innovative training network fellowship of the European commission’s horizon 2020 program under contract number 642889 7