Endoscopy - To exclude mucosal injury in: Atypical symptoms Unresponsive to treatment - Alarm factors: Dysphagia weight loss Recurrent occult or gross bleeding vomiting Jaundice Lymphadenopathy palpable mass family history of GI malignancy Unexplained dyspepsia Screen Barrett`s metaplasia: Heartburn >5 yrs duration especially in patients >50 yrs